N-Acetylcysteine for Adolescent Alcohol Use Disorder

Summary

This is a 8-week randomized, placebo-controlled trial testing the effects of N-acetylcysteine (NAC), on a platform of weekly evidence-based brief alcohol intervention for 120 adolescents with alcohol use disorder (AUD). The primary efficacy endpoint is reduction in alcohol use (total standard drinks), compared between NAC and placebo groups.

Timeline

Start

2019-02-27

Primary completion

2024-02-26

Completion

2024-02-26

Publications

• Squeglia LM, Tomko RL, Baker NL, Kirkland AE, McClure EA, Gray KM. A Randomized Controlled Trial of N-acetylcysteine for Adolescent and Young Adult Alcohol Use Disorder. J Am Acad Child Adolesc Psychiatry. 2025 Sep 26:S0890-8567(25)02088-X. doi: 10.1016/j.jaac.2025.09.025. Online ahead of print.

Drugs

Indications