Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans

Summary

Objectives: This proposal addresses the overall hypothesis that ambient fine particulate matter exerts cardiovascular health effects via alteration of endothelial homeostasis, through a mechanism mediated by oxidative stress. This project will use a controlled human inhalation exposure to diesel exhaust particulate (DEP) as a model to address the following objectives: 1) Determine whether exposure to inhaled DEP is associated with endothelial dysfunction in a concentration-related manner; 2) Determine whether exposure to inhaled DEP is associated with evidence of systemic oxidative stress; and 3) Determine whether antioxidant supplementation blunts the DEP effect on endothelial function.

Timeline

Start

2008-07

Primary completion

2010-08

Completion

2010-08

Publications

• Cosselman KE, Krishnan RM, Oron AP, Jansen K, Peretz A, Sullivan JH, Larson TV, Kaufman JD. Blood pressure response to controlled diesel exhaust exposure in human subjects. Hypertension. 2012 May;59(5):943-8. doi: 10.1161/HYPERTENSIONAHA.111.186593. Epub 2012 Mar 19.

Drugs

Indications

No indication recorded.