Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?

Summary

Accumulation of iron in patients with beta thalassemia major causes free radical formation which leads to damage of biological membranes. Sperm DNA damage may result from these generated antioxidants. We aimed at investigating the current DNA damage in the sperms of adult patients with beta thalassemia major and the effect generated by giving antioxidant treatment for 6 months.

Timeline

Start

2015-02

Primary completion

2017-12

Completion

2017-12

Drugs

Indications