Drugs / L-carnitine
last change Aug 2026 re-read 9 days ago

L-carnitine

Other / unclassified targets PPARG

Developed for
end stage renal failure · polycystic ovary syndrome · disorder of carnitine cycle and carnitine transport · infectious disease with sepsis · male infertility · acute kidney injury · AIDS · anemia
+59 more · disorder of fatty acid and ketone body metabolism · glucose intolerance · heart failure · oligoasthenoteratozoospermia · alcohol-related disorders · Alzheimer disease · amyotrophic lateral sclerosis · asthma · atrioventricular septal defect · chemotherapy-induced neuropathy · cirrhosis of liver · COVID-19 · diabetes mellitus · dialysis disequilibrium syndrome · DNA repair disease · heart disorder · hepatitis B virus infection · HIV infectious disease · hyperlipidemia · hypotensive disorder · impaired renal function disease · keratoconjunctivitis · lactic acidosis · metabolic dysfunction-associated steatohepatitis · morbid obesity · multiple sclerosis · myocardial stunning · myopathy · NAFLD1 · neoplasm · neurodevelopmental disorder · osteoarthritis, knee · Parkinson disease · phenylketonuria · poisoning · postpoliomyelitis syndrome · respiratory distress syndrome in premature infants · respiratory failure · rheumatoid arthritis · Sjogren syndrome · spinal cord injury · spinal muscular atrophy · spinal muscular atrophy, type 1 · tinnitus · toxic polyneuropathy · type 1 diabetes mellitus · ventricular septal defect · acute pyelonephritis · atrial fibrillation · beta thalassemia · beta-thalassemia intermedia · cisplatin toxicity · gastrointestinal stromal tumor · hypothyroidism · liver disorder · oligospermia · protein-energy malnutrition · sickle cell disease · spermatogenic failure
Investigated by
Ain Shams University · Iperboreal Pharma Srl · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · ScandiBio Therapeutics AB · Assiut University · Canadian Institutes of Health Research (CIHR)
+91 more · Families of Spinal Muscular Atrophy · Istanbul Medipol University Hospital · KTH Royal Institute of Technology · Leadiant Biosciences, Inc. · Maastricht University Medical Center · MonitorCRO · Nîmes University Hospital · Sahlgrenska University Hospital · Tanta University · Tehran University of Medical Sciences · University of California, San Francisco · University of Utah · Abbott · Alanya Alaaddin Keykubat University · Alanya Allaaddin Keykubat University Hospital · American Heart Association · Assistance Publique - Hôpitaux de Paris · Augusta University · Bagcilar Training and Research Hospital · Bahria University · Bakirkoy Dr. Dr. Sadi Konuk Research and Training Hospital · Biolab Sanus Farmaceutica · Brown University · Canakkale 18 Mart University Health Research and Application Hospital · ChaodongWang · Children's Hospital of Orange County · Colorado State University · Darya Chamani · Dr. Lutfi Kirdar Kartal Training and Research Hospital · German University in Cairo · Göteborg University · HealthPartners Institute · Helsinki University Central Hospital · Hospital de Clínicas Dr. Manuel Quintela · IlDong Pharmaceutical Co Ltd · Imperial Clinical Trials Unit (ICTU) · Imperial College London · Isfahan University of Medical Sciences · Jinnah Postgraduate Medical Centre · Kanuni Sultan Suleyman Training and Research Hospital · Koc University Hospital · Koç University · Laboratorios Grossman, S.A. · Leading Edge Clinic · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Mansoura University · Merck Sharp & Dohme LLC · Montefiore Medical Center · Mst.Sumyara Khatun · Muhammad Aamir Latif · National Cancer Institute (NCI) · National Center for Complementary and Integrative Health (NCCIH) · National Institute of Allergy and Infectious Diseases (NIAID) · National Institute of General Medical Sciences (NIGMS) · National Institute of Nursing Research (NINR) · National Institute of Public Health, Mexico · National Institute on Alcohol Abuse and Alcoholism (NIAAA) · National Taiwan University Hospital · Nestlé · Ondokuz Mayıs University · Ontario HIV Treatment Network · Ottawa Heart Institute Research Corporation · Pakistan Navy Station Shifa Hospital · Penn State University · Queen's University · Rebuild Medicine Inc · Rhode Island Hospital · Royan Institute · Shaikh Zayed Hospital, Lahore · South Valley University · The First Affiliated Hospital of Zhejiang Chinese Medical University · The Gerber Foundation · Toujinkai Hospital · Umraniye Education and Research Hospital · all 97 on the full record

Regulatory milestones approvals, filings & regulatory actions · 3 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (2) US (FDA) CARNITOR — 1992-12-16 – 1999-12-15 fda.gov ↗
Approved US (FDA) CARNITOR — 1985-12-27 fda.gov ↗

Trials 75 · started per year

today
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 04 trials
Phase 0 NCT07201714 Nov 2025 → Dec 2026 expected disorder of carnitine cycle and carnitine transport, heart failure London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Recruiting No outcome recorded
Phase 0 NCT05948124 Aug 2023 → Feb 2024 disorder of fatty acid and ketone body metabolism Ain Shams University Unknown No outcome recorded
Phase 0 NCT05501899 Mar 2023 → Dec 2024 overdue acute lymphoblastic leukemia, poisoning Children's Hospital of Orange County Recruiting No outcome recorded
Phase 0 NCT06198803 Jan 2022 → Jan 2024 disorder of carnitine cycle and carnitine transport Ain Shams University Unknown No outcome recorded
Phase 13 trials
Phase 1 NCT05355311 Sep 2024 → May 2025 alcohol-related disorders Brown University Completed No outcome recorded
Phase 1 NCT01825369 Dec 2014 → Jul 2020 atrioventricular septal defect, ventricular septal defect University of California, San Francisco Withdrawn No outcome recorded
Phase 1 NCT01193777 Sep 2010 → Feb 2012 infectious disease with sepsis Wake Forest University Health Sciences Terminated No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT03014882 Feb 2015 → Dec 2017 DNA repair disease, endocrine system disorder, male infertility Ain Shams University Unknown No outcome recorded
Phase 1/2 NCT00661453 Apr 2008 → May 2012 spinal muscular atrophy, type 1 University of Utah Completed No outcome recorded
Phase 226 trials · 4 missed
Phase 2 NCT07567274 May → Jul 2026 overdue tinnitus Leading Edge Clinic Enrolling by invitation No outcome recorded
Phase 2 NCT06960694 Jun → Nov 2025 osteoarthritis, knee Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Completed No outcome recorded
Phase 2 NCT06564909 Jun 2025 → Dec 2026 expected myocardial stunning Ain Shams University Active not recruiting No outcome recorded
Phase 2 NCT06753565 Dec 2024 → Jun 2025 overdue rheumatoid arthritis German University in Cairo Recruiting No outcome recorded
Phase 2 NCT03953703 Nov 2021 → Sep 2025 Sjogren syndrome, keratoconjunctivitis Vanderbilt University Medical Center Completed No outcome recorded
Phase 2 NCT07249229 Nov 2020 → Feb 2021 end stage renal failure Darya Chamani Completed No outcome recorded
Phase 2 NCT04044131 Dec 2019 → Mar 2021 Alzheimer disease, Parkinson disease Istanbul Medipol University Hospital Completed No outcome recorded
Phase 2 NCT04086212 Oct 2019 → Dec 2022 end stage renal failure Iperboreal Pharma Srl Withdrawn No outcome recorded
Phase 2 NCT04001036 Sep 2019 → Aug 2022 end stage renal failure Iperboreal Pharma Srl Terminated No outcome recorded
Phase 2 NCT04330326 Jul 2019 → Jul 2020 NAFLD1 ScandiBio Therapeutics AB Completed No outcome recorded
Phase 2/36 trials
Phase 2/3 NCT07669402 Dec 2023 → Feb 2026 oligoasthenoteratozoospermia Tehran University of Medical Sciences Completed No outcome recorded
Phase 2/3 NCT05817799 Jan → Jul 2023 — Bahria University Completed No outcome recorded
Phase 2/3 NCT04573153 Sep 2020 → May 2022 COVID-19 ScandiBio Therapeutics AB Terminated No outcome recorded Stop: Enrollment
Phase 2/3 NCT03180424 Jan → Aug 2017 carnitine deficiency, myopathic Hospital de Clínicas Dr. Manuel Quintela Unknown No outcome recorded
Phase 2/3 NCT01783041 Jan 2013 → Dec 2020 disorder of carnitine cycle and carnitine transport, neurodevelopmental disorder Montefiore Medical Center Completed No outcome recorded
Phase 2/3 NCT00247975 Mar 2006 → Oct 2010 heart failure Ottawa Heart Institute Research Corporation Terminated No outcome recorded Stop: Enrollment
Phase 310 trials
Phase 3 NCT07402759 Jan → Jun 2026 overdue oligoasthenoteratozoospermia South Valley University Active not recruiting No outcome recorded
Phase 3 NCT05905692 May → Dec 2023 — Ain Shams University Unknown No outcome recorded
Phase 3 NCT05632549 Aug 2022 → Aug 2024 asthma Tanta University Unknown No outcome recorded
Phase 3 NCT03696940 May 2018 → Mar 2019 hyperlipidemia Laboratorios Grossman, S.A. Unknown No outcome recorded
Phase 3 NCT02664753 Mar 2018 → Dec 2024 acute kidney injury, infectious disease with sepsis Nîmes University Hospital Terminated No outcome recorded
Phase 3 NCT01786824 Dec 2014 → Aug 2015 acute kidney injury, impaired renal function disease Nîmes University Hospital Terminated No outcome recorded
Phase 3 NCT01149525 Jun 2010 → Mar 2013 multiple sclerosis University Hospital, Bordeaux Completed No outcome recorded
Phase 3 NCT00322322 Jun 2006 → Jun 2010 thyroid hormone metabolism, abnormal Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 3 NCT01549847 ? → Feb 2013 postpoliomyelitis syndrome Biolab Sanus Farmaceutica Withdrawn No outcome recorded
Phase 3 NCT00002220 — HIV infectious disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 411 trials
Phase 4 NCT07160452 Sep 2025 → Mar 2026 overdue anemia, end stage renal failure, kidney failure Shaikh Zayed Hospital, Lahore Not yet recruiting No outcome recorded
Phase 4 NCT06901323 Feb 2025 → Mar 2026 overdue phenylketonuria Mansoura University Active not recruiting No outcome recorded
Phase 4 NCT06849115 Jul → Dec 2024 amyotrophic lateral sclerosis ChaodongWang Completed No outcome recorded
Phase 4 NCT05673239 Jan → Jun 2023 — The First Affiliated Hospital of Zhejiang Chinese Medical University Completed No outcome recorded
Phase 4 NCT05322447 Apr → Aug 2022 respiratory failure Ain Shams University Completed No outcome recorded
Phase 4 NCT03630367 Oct 2018 → Sep 2020 — Assiut University Withdrawn No outcome recorded
Phase 4 NCT03604016 Sep 2018 → Jul 2020 hepatitis B virus infection IlDong Pharmaceutical Co Ltd Unknown No outcome recorded
Phase 4 NCT03630341 Feb 2016 → Mar 2018 polycystic ovary syndrome Assiut University Completed No outcome recorded
Phase 4 NCT00754767 Jan 2007 → Apr 2008 breast cancer, chemotherapy-induced neuropathy, toxic polyneuropathy HealthPartners Institute Terminated No outcome recorded Stop: Enrollment
Phase 4 NCT00173706 Oct 2004 → ? anemia, heart disorder, hypotensive disorder, myopathy National Taiwan University Hospital Unknown No outcome recorded
Phase not applicable13 trials · 1 missed
— NCT07437391 Jan → Jun 2026 overdue respiratory distress syndrome in premature infants Muhammad Aamir Latif Recruiting No outcome recorded
— NCT07266259 Sep 2025 → Aug 2026 overdue polycystic ovary syndrome Mst.Sumyara Khatun Recruiting No outcome recorded
— NCT06689501 Oct 2024 → Jun 2025 morbid obesity Nestlé Completed No outcome recorded
— NCT06042738 Mar → Nov 2021 male infertility Ondokuz Mayıs University Completed No outcome recorded
— NCT04672720 Mar 2020 → Dec 2022 polycystic ovary syndrome Royan Institute Completed Missed primary
— NCT03230812 Mar 2018 → Nov 2019 glucose intolerance Maastricht University Medical Center Completed No outcome recorded
— NCT03476356 Nov 2017 → Mar 2018 polycystic ovary syndrome Ain Shams University Completed No outcome recorded
— NCT03660293 Apr 2017 → Jun 2019 type 1 diabetes mellitus Tanta University Completed No outcome recorded
— NCT03372772 Mar → Dec 2017 — Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Unknown No outcome recorded
— NCT02722902 May 2016 → Jun 2017 glucose intolerance Maastricht University Medical Center Terminated No outcome recorded
Comparator or background therapy37 trials
Phase 0 NCT06342856 Comparator Jun 2023 → Jun 2024 oligospermia Ain Shams University Unknown No outcome recorded
Phase 0 NCT05487781 Background May → Jun 2022 — Molecule X LLC Unknown No outcome recorded
Phase 0 NCT03953248 Comparator Jan 2016 → Jan 2018 poisoning Heba Allah Ali Abd El-Halim Mabrouk Completed No outcome recorded
Phase 2 NCT07216001 Background May 2026 → Dec 2027 expected autism, childhood apraxia of speech Claudia R. Morris Not yet recruiting No outcome recorded
Phase 2 NCT07108777 Comparator Aug 2025 → Aug 2026 overdue cisplatin toxicity Tanta University Recruiting No outcome recorded

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2021-11-10 Saptalis Pharmaceuticals LLC Regulatory Received FDA approval for its ANDA for Levocarnitine Oral Solution saptalis.com ↗
Saptalis Pharmaceuticals, LLC announced today that it has received FDA approval for its ANDA for Levocarnitine Oral Solution 1gm/10mL.

All press releases naming this drug 1 release

DateIssuerRelease

Evidence & citations 12 cited values

Every value below carries the sentence it was read from. 117 sources stand behind the page.

FieldValueCited text
Known as L-carnitine “L-carnitine group received anthracycline-containing chemotherapy in a dose of 50 mg/m2 plus L-carnitine 3 gm L-carnitine® capsules obtained from (MEPACO) was taken PO one day...” NCT04434404 ↗
92

“food supplement containing 2000 mg L-carnitine, 2000 mg fructose, 932 mg acetyl L-carnitine, 225 mg vitamin C, 115 mg citric acid, 50 mg coenzyme Q10, 14 mg zinc, 115 µg...” NCT06042738 ↗

“Tablet: Vitamin C, 500 mg; Vitamin D3, 1000 IU; Vitamin E, 400 IU; Folic Acid 1000 mcg; Zinc, 20 mg; Selenium 200 mcg; Lycopene, 10 mg; Capsule: Vitamin D3, 1000 IU,...” NCT02421887 ↗

“The purpose of the study to assess the efficacy of adding L-carnitine to clomiphene citrate for increasing the ovulation and the pregnancy rate in women with PCOS.” NCT03476356 ↗

“This group will receive the standard chemotherapy protocol (cisplatin -based chemotherapy) plus L-carnitine 350 mg (L-carnitine®) three times daily by oral.” NCT07108777 ↗

“Participants will receive antioxidant therapy consisting of vitamin C 1000 mg/day, vitamin E 400 IU/day, L-carnitine, and zinc 25 mg/day for 6 months.” NCT07862725 ↗

“Instillation of a PD solution containing xylitol (1.5%), L-carnitine (0.1%) and glucose (0.5%) for the nocturnal exchange in CAPD treated patients.” NCT00858182 ↗

“The L-carnitine syrup formulation will be provided to study participant at nutritional rehabilitation unit (NRU) under controlled set-up” NCT05083637 ↗

“The study product is blend of ingredients composed of L-carnitine tartrate, dihydrocapsiate and protein yeast hydrolysate (DNF-10®).” NCT06689501 ↗

“First, the investigators will include L-carnitine to enhance the transport of fatty acids across the mitochondrial membrane” NCT04330326 ↗

“L-carnitine is an important factor in fatty acid metabolism, and carnitine deficiency is common in dialysis patients.” PMID 33139659 ↗ Nov 2020

Show 82 more sources

Known as Carnitene “All subjects will undergo oral Carnitene (L-Carnitine or levocarnitine) supplementation for 96 days.” NCT03230812 ↗
Known as carnitine “Carnitine is the essential cofactor for various enzyme activities of human metabolism, especially for the mitochondrial carnitine shuttle that transfers long-chain fatty acids...” NCT00841295 ↗
Known as Carnitor ClinicalTrials.gov intervention name — accepted as the source's own label NCT02722902 ↗
Known as L-Carnitina ClinicalTrials.gov intervention name — accepted as the source's own label NCT05487781 ↗
Known as L-carnitine hydrochloride “HSK16149 20mg BID with L-carnitine hydrochloride tablets 2 tablets TID ;Lipoic acid tablets 2 tablets BID with L-carnitine hydrochloride tablets 2 tablets TID;” NCT06122012 ↗
Known as L-carnitine tartrate “Treatment arm will include dietary supplement consisting of serine, L-carnitine tartrate, N-acetylcysteine and nicotinamide riboside + standard therapy (hydroxychloroquine).” NCT04573153 ↗
Known as L-carnitine: Carnitor “L-carnitine: Carnitor” NCT00202228 ↗
Known as Levocarnitine “Several experimental studies have shown that levocarnitine reduces myocardial injury after ischemia and reperfusion by counteracting the toxic effect of high levels of free...” PMID 15591005 ↗ Nov 2004
27

“Levocarnitine (L-carnitine) is a micronutrient found in meat and dairy products that plays a major role in energy metabolism.” NCT00079599 ↗

“All subjects will undergo oral Carnitene (L-Carnitine or levocarnitine) supplementation for 96 days.” NCT03230812 ↗

“Drug: Valproic Acid and Levocarnitine; capsules” NCT00481013 ↗

NCT05501899 ↗

NCT01671384 ↗

NCT07160452 ↗

NCT07201714 ↗

NCT03953703 ↗

NCT00002379 ↗

NCT00002220 ↗

Show 17 more sources

Modality Other / unclassified “L-carnitine is an amino acid derivative that is thought to be helpful for treating renal anemia in hemodialysis patients.” PMID 33713287 ↗ Mar 2021
Route Oral “500 mg tablet taken orally daily” NCT00001082 ↗
Target PPARG “LC also have anti-inflammatory effect by acting on PPAR gamma” NCT06753565 ↗