drugset / Trial / NCT01786824
Preventing Contrast-induced Nephropathy: Evaluating Hydration Strategies and L-carnitine Administration
RandomizedFactorialOpen-labelPrevention
Summary
The general objective of this open, pilot study is to characterize biological parameters related to acute kidney injury among patients undergoing a programmed coronarography with injection of contrast material. The study focuses on two main factors that may influence acute kidney injury: (1) sodium chloride hydration strategy versus sodium bicarbonate hydration strategy and (2) presence of oral L-carnitine treatment versus absence of oral L-carnitine treatment. We will also test for a potential interaction between these two factors.
Timeline
- Start
- 2014-12
- Primary completion
- 2015-08
- Completion
- 2015-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | L-carnitine | Other / unclassified | 3 g | Oral |
| Subject | sodium bicarbonate | Diagnostic / imaging agent | 1.4 % | Intravenous |
| Subject | sodium bicarbonate | Diagnostic / imaging agent | 500 ml | Intravenous |
| Subject | sodium chloride | Unknown | 0.9 % | Intravenous |