drugset / Trial / NCT05355311
Enhancing the Effects of Alcohol Treatment With L-Carnitine
Phase 1
Completed
24 enrolled
Brown University
Colorado State University · collabNational Institute on Alcohol Abuse and Alcoholism (NIAAA) · collabRhode Island Hospital · collab
NaSingle-groupOpen-labelTreatment
Summary
The primary objective of this study is to evaluate the effects of L-carnitine, 2.97g daily on alcohol cue-elicited alcohol craving during a human laboratory paradigm after 4 weeks of daily dosing among participants ages 18-25 with alcohol use disorder (AUD) as confirmed by the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5™) and who report at least mild depressive symptoms on the Beck Depression Inventory-II. Secondary objectives include evaluation of L-carnitine (2.97g/day) on alcohol craving and use, subjective effects of alcohol consumption, mood, sleep, alcohol use negative consequences, study retention, and safety and tolerability.
Timeline
- Start
- 2024-09-27
- Primary completion
- 2025-05-31
- Completion
- 2025-05-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | L-carnitine | Other / unclassified | 2.97 g | — |