Contrast Agent-associated Nephrotoxicity in Intensive Care Unit Patients

Phase 0 Unknown 100 enrolled University of Thessaly

RandomizedParallel-groupSingle-blindPrevention

Summary

The use of N-acetylcysteine and ascorbic acid reduce the incidence of radiographic contrast agent induced reduction in renal function in Intensive Care Unit patients.

Timeline

Start: 2009-01
Primary completion: 2010-01
Completion: 2010-06

Outcome

Missed primary endpoint

paper Contrast-induced nephropathy in NacA and CG were 18.33% and 15.6%, respectively (p = 0.81). PMID 29089038 ↗

paper Intravenous administration of N-acetylcysteine and ascorbic acid failed to reduce contrast-induced nephropathy in critically ill patients PMID 29089038 ↗

Publications

Palli E, Makris D, Papanikolaou J, Garoufalis G, Tsilioni I, Zygoulis P, Zakynthinos E. The impact of N-acetylcysteine and ascorbic acid in contrast-induced nephropathy in critical care patients: an open-label randomized controlled study. Crit Care. 2017 Oct 31;21(1):269. doi: 10.1186/s13054-017-1862-3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	N-acetylcysteine	Small molecule	1200 mg	Intravenous
Subject	Vitamin C	Other / unclassified	1.5 g	Intravenous