drugset / Trial / NCT06083480
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
Phase 4
Recruiting
148 enrolled
Vanderbilt University Medical Center
National Institute on Aging (NIA) · collab
RandomizedParallel-groupQuadruple-blindPrevention
Summary
This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent antioxidant intervention (glycine + N-acetyl-cysteine(GlyNAC)) reduces oxidative stress and chronic post surgical pain (CPSP) in patients undergoing total knee arthroplasty (TKA).
Timeline
- Start
- 2024-12-06
- Primary completion
- 2028-09
- Completion
- 2029-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Glycine | Other / unclassified | 100 mg | Oral |
| Subject | N-acetylcysteine | Small molecule | 100 mg | Oral |