Clinical Trial of Antioxidant Therapy in Patients With Septic Shock

Summary

Sepsis and septic shock are public health problems worldwide that represents an excessive cost for health systems. Despite the great technological and research advances, mortality can reach up to 80% in patients with multiple organ failure (FOM). Therapeutic studies focused on evaluating the usefulness of the use of antioxidants have shown different outcomes and results. This randomized clinical trial in patients with septic shock at two general intensive care units try to evaluate the usefulness of four different antioxidant therapies added to the conventional treatment, which includes: n-acetyl cysteine, vitamin C, vitamin E and melatonin. Measurement of parameters before and after treatment of oxidative stress includes nitrates and nitrites, lipid peroxidation, glutathione peroxidase, glutathione s transferase, extracellular activity of SOD, GSH concentration and evaluation of total antioxidant capacity. The investigators will also evaluate the clinical impact of antioxidant therapy with the SOFA score.

Timeline

Start

2018-07-23

Primary completion

2022-06

Completion

2022-06

Publications

• Aisa-Alvarez A, Perez-Torres I, Guarner-Lans V, Manzano-Pech L, Cruz-Soto R, Marquez-Velasco R, Casarez-Alvarado S, Franco-Granillo J, Nunez-Martinez ME, Soto ME. Randomized Clinical Trial of Antioxidant Therapy Patients with Septic Shock and Organ Dysfunction in the ICU: SOFA Score Reduction by Improvement of the Enzymatic and Non-Enzymatic Antioxidant System. Cells. 2023 May 6;12(9):1330. doi: 10.3390/cells12091330.

Drugs

Indications