Vitamin E

also known as Vit E · alpha tocopherol · α-tocopherol · DL-alpha tocopherol · Alfa-Tocoferol · all rac-α-tocopheryl acetate · RRR alpha tocopherol acetate · rrr- -tocopherol · +4 more

Other / unclassified

Developed for: NAFLD1 · prostate cancer · diabetes mellitus · Alzheimer disease · anemia · metabolic dysfunction-associated steatohepatitis · cataract · chronic kidney disease
+88 more
· diabetic retinopathy · fatty liver disease · infectious disease with sepsis · liver disorder · myocardial infarction · poisoning · preeclampsia · rheumatoid arthritis · urinary bladder cancer · acute kidney injury · acute respiratory distress syndrome · adrenomyeloneuropathy · age-related macular degeneration · alveolar periostitis · amyotrophic lateral sclerosis · arterial occlusion · atherosclerosis · breast disorder · breast fibrosis · burning mouth syndrome · cardiovascular disorder · central serous chorioretinopathy · colorectal adenoma · colorectal cancer · colorectal carcinoma · coronary atherosclerosis · COVID-19 · cystoid macular edema · diabetic macular edema · dry eye syndrome · epilepsy · fibrotic liver disease · fragile X syndrome · Gaucher disease · head and neck neoplasm · hyperinsulinism-hyperammonemia syndrome · hyperpigmentation of the skin · intracerebral hemorrhage · macular degeneration · macular retinal edema · male infertility · migraine disorder · mitochondrial disease · mouth mucosa disorder · multiple sclerosis · necrotizing soft tissue infection · nephrolithiasis, calcium oxalate · noise induced hearing loss · obstructive sleep apnea syndrome · oral erosive lichen · oral submucous fibrosis · perinatal asphyxia · peripheral neuropathy · polycystic ovary syndrome · precancerous condition · primary dysmenorrhea · radiation-induced disorder · restless legs syndrome · retinitis pigmentosa · root resorption · sickle cell disease · skin pigmentation disorder · sleep apnea syndrome · subarachnoid hemorrhage · swine influenza · thalassemia · trisomy 21 · uveitis · viral pneumonia · bacterial pneumonia · blood coagulation disease · breast cancer · depressive disorder · endometriosis · hyperlipidemia · iron deficiency anemia · metabolic dysfunction-associated steatotic liver disease · nutritional deficiency disease · oligoasthenoteratozoospermia · palmar fibromatosis · preterm premature rupture of the membranes · primary ovarian failure · psoriasis · respiratory system disorder · retinal disorder · retinopathy of prematurity · schizophrenia · vitamin deficiency disorder
Investigated by: National Eye Institute (NEI) · Ain Shams University · National Cancer Institute (NCI) · National Heart, Lung, and Blood Institute (NHLBI) · Hospital General Universitario Elche · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
+136 more
· National Center for Complementary and Integrative Health (NCCIH) · National Institute on Aging (NIA) · SWOG Cancer Research Network · University Health Network, Toronto · University of Guadalajara · Alzheimer's Disease Cooperative Study (ADCS) · Bambino Gesù Hospital and Research Institute · Clalit Health Services · Mexican Social Security Institute · National Center for Research Resources (NCRR) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Second Affiliated Hospital, School of Medicine, Zhejiang University · Technion, Israel Institute of Technology · University of Pennsylvania · Aga Khan University · Alcon Research · Altamash Institute of Dental Medicine · American British Cowdray Medical Center · Amsterdam UMC, location VUmc · Aristotle University Of Thessaloniki · Asian Institute of Gastroenterology, India · Augusta University · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · Bill and Melinda Gates Foundation · Brigham and Women's Hospital · Bristol-Myers Squibb · CCERN: canadian cancer etiology research network · Cancer and Leukemia Group B · Centre Hospitalier Universitaire Vaudois · Chiang Mai University · Children's Hospital of Philadelphia · Crohn's and Colitis Foundation · D. Walter Wray · Dallas VA Medical Center · Delos Clinical · Dr Cipto Mangunkusumo General Hospital · Dr Rabia Arshad · Eastern Cooperative Oncology Group · Faculdade de Medicina de Botucatu, UNESP, Botucatu, Brasil · Feculdade de Medicina da Universidade de Sao Paulo - Brasil · Federal University of Pernambuco · Federico II University · Felipe Melo Cruz · First Affiliated Hospital Xi'an Jiaotong University · Fogarty International Center of the National Institute of Health · Fresenius Kabi · Fudan University · Fundacion Hesperia · Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud · Global Network for Women's and Children's Health Research · Guiyang Hospital of Stomatology · Guy's and St Thomas' NHS Foundation Trust · Hams Hamed Abdelrahman · Hearing Health Science, Inc. · Hospital Civil de Guadalajara · Hospital de Clinicas de Porto Alegre · IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy · Indonesia University · Innovaderm Research Inc. · Institute of Child Health · Instituto Nacional de Cardiologia Ignacio Chavez · Johane Allard · Johns Hopkins Bloomberg School of Public Health · Klira Skin · LILT (Italian league against cancer) · Lawson Wilkins Pediatric Endocrine Society · Legacy Health System · Mahidol University · Masonic Cancer Center, University of Minnesota · Mayo Clinic · Medical Research Foundation, The Netherlands · Memorial Hermann Hospital · Ministerio de Sanidad, Servicios Sociales e Igualdad · Misr University for Science and Technology · all 142 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	BEROCCA PN	—	1947-07-28	fda.gov ↗

Trials 101 · started per year

today

US approved 1947

1946194719481949195019511952195319541955195619571958195919601961196219631964196519661967196819691970197119721973197419751976197719781979198019811982198319841985198619871988198919901991199219931994199519961997199819992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027202820292030

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 02 trials
Phase 0	NCT04481841	Jul 2020 → Feb 2022	burning mouth syndrome, mouth mucosa disorder	Second Affiliated Hospital, School of Medicine, Zhejiang University	Unknown	No outcome recorded
Phase 0	NCT00860743	Sep 2009 → Sep 2013	sleep apnea syndrome	VA Office of Research and Development	Completed	No outcome recorded
Phase 18 trials
Phase 1	NCT06847880	Feb 2025 → Feb 2026	root resorption	University of Baghdad	Completed	No outcome recorded
Phase 1	NCT01193270	Oct 2010 → Aug 2011	fetal growth restriction, intracerebral hemorrhage	NICHD Neonatal Research Network	Completed	No outcome recorded
Phase 1	NCT02966665	Sep 2008 → Aug 2030 expected	chronic obstructive pulmonary disease, heart failure, pulmonary arterial hypertension	D. Walter Wray	Recruiting	No outcome recorded
Phase 1	NCT00399282	Oct 2006 → Apr 2007	rheumatoid arthritis	Shahid Beheshti University of Medical Sciences	Completed	No outcome recorded
Phase 1	NCT00117403	Jan 2006 → Sep 2007	Alzheimer disease	National Institute on Aging (NIA)	Completed	No outcome recorded
Phase 1	NCT00055042	Feb 2003 → Jan 2004	diabetes mellitus, macular retinal edema	National Eye Institute (NEI)	Completed	No outcome recorded
Phase 1	NCT00027287	Nov 2001 → Dec 2002	diabetes mellitus, diabetic macular edema	National Eye Institute (NEI)	Completed	No outcome recorded
Phase 1	NCT00021645	Jul 2001 → Jun 2004	cystoid macular edema, uveitis	National Eye Institute (NEI)	Completed	No outcome recorded
Phase 1/22 trials
Phase 1/2	NCT07668284	Dec 2026 → Feb 2030 expected	anus cancer, cervical cancer, prostate cancer	University of Nebraska	Not yet recruiting	No outcome recorded
Phase 1/2	NCT00010842	Sep 1999 → Dec 2004	multiple sclerosis	National Center for Complementary and Integrative Health (NCCIH)	Completed	No outcome recorded
Phase 223 trials · 3 missed
Phase 2	NCT04244630	Nov 2023 → Jul 2026 overdue	amyotrophic lateral sclerosis	Dallas VA Medical Center	Active not recruiting	No outcome recorded
Phase 2	NCT05771181	Mar 2023 → Dec 2025 overdue	colorectal carcinoma	Fudan University	Recruiting	No outcome recorded
Phase 2	NCT04984798	Nov 2022 → Mar 2023	hyperinsulinism-hyperammonemia syndrome	Children's Hospital of Philadelphia	Withdrawn	No outcome recorded
Phase 2	NCT04198805	Jan 2020 → Sep 2022	NAFLD1, metabolic dysfunction-associated steatohepatitis	Naga P. Chalasani	Completed	No outcome recorded
Phase 2	NCT03674385	Jul 2018 → Mar 2019	polycystic ovary syndrome	Ain Shams University	Completed	No outcome recorded
Phase 2	NCT02421887	Dec 2015 → Jun 2018	male infertility	Yale University	Completed	Missed primary
Phase 2	NCT02397486	May 2015 → Jun 2018	head and neck neoplasm	Ain Shams University	Completed	No outcome recorded
Phase 2	NCT02468518	Mar → Dec 2015	poisoning	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	Completed	No outcome recorded
Phase 2	NCT02171104	Jul 2014 → Jan 2026 overdue	Hurler syndrome, Krabbe disease, Niemann-Pick disease type B, Niemann-Pick disease, type C2 +15	Masonic Cancer Center, University of Minnesota	Active not recruiting	No outcome recorded
Phase 2	NCT01495260	Sep 2011 → Nov 2013	adrenomyeloneuropathy	Pujol, Aurora, M.D.	Completed	No outcome recorded
Phase 2	NCT01554345	Jun 2011 → Aug 2012	acute kidney injury	Tehran University of Medical Sciences	Unknown	No outcome recorded
Phase 2	NCT02062034	Feb 2011 → Nov 2013	diabetic retinopathy, type 2 diabetes mellitus	University of Guadalajara	Completed	No outcome recorded
Phase 2	NCT01147523	Jan → Nov 2010	metabolic dysfunction-associated steatohepatitis	Aristotle University Of Thessaloniki	Completed	No outcome recorded
Phase 2	NCT01523574	Aug 2009 → Nov 2010	peripheral neuropathy	Felipe Melo Cruz	Completed	Missed primary
Phase 2	NCT00844792	Oct 2008 → Dec 2013	prostate cancer	University Health Network, Toronto	Completed	No outcome recorded
Phase 2	NCT00808470	Oct 2008 → Dec 2013	noise induced hearing loss	University of Michigan	Completed	Missed primary
Phase 2	NCT00744549	May 2008 → Dec 2013	prostate cancer	University Health Network, Toronto	Completed	No outcome recorded
Phase 2	NCT00963131	Dec 2004 → Dec 2008	central serous chorioretinopathy	Prince of Songkla University	Completed	No outcome recorded
Phase 2	NCT00152815	Oct 2003 → Dec 2010	HIV infectious disease, NAFLD1	Johane Allard	Terminated	No outcome recorded
Phase 2	NCT00583700	Feb 2003 → May 2010	breast fibrosis	University of Iowa	Completed	No outcome recorded
Phase 2	NCT00152841	Jun 2002 → Feb 2009	Crohn disease, anemia, ulcerative colitis	University Health Network, Toronto	Terminated	No outcome recorded
Phase 2	NCT00067899	Sep 2000 → Dec 2005	—	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Completed	No outcome recorded
Phase 2	NCT00000600	Jun 1995 → May 2000	atherosclerosis, carotid artery disorder, heart disorder, intracranial arteriosclerosis	National Heart, Lung, and Blood Institute (NHLBI)	Terminated	No outcome recorded

Phase 2/37 trials · 1 met primary
Phase 2/3	NCT06915701	Feb → Dec 2026 expected	rheumatoid arthritis	University of Guadalajara	Recruiting	No outcome recorded
Phase 2/3	NCT01749371	Feb 2013 → Aug 2017	—	The University of Texas Medical Branch, Galveston	Completed	No outcome recorded
Phase 2/3	NCT01125033	Mar 2008 → Jan 2009	chronic kidney disease, restless legs syndrome	Shiraz University of Medical Sciences	Completed	No outcome recorded
Phase 2/3	NCT00314379	Apr 2006 → Dec 2007	cardiovascular disorder	Technion, Israel Institute of Technology	Completed	No outcome recorded
Phase 2/3	NCT00220831	Apr 2005 → Dec 2009	diabetes mellitus, myocardial infarction	Technion, Israel Institute of Technology	Terminated	Met primary
Phase 2/3	NCT00275600	Jan 2003 → Sep 2007	breast disorder	Mayo Clinic	Completed	No outcome recorded
Phase 2/3	NCT00311116	Jul 2002 → Feb 2005	cancer	The Hospital for Sick Children	Completed	No outcome recorded
Phase 332 trials · 1 met primary · 6 missed
Phase 3	NCT06211478	Mar → Sep 2023	Gaucher disease	Ain Shams University	Completed	No outcome recorded
Phase 3	NCT04193982	Jan → Sep 2021	NAFLD1	Asian Institute of Gastroenterology, India	Unknown	No outcome recorded
Phase 3	NCT04362384	May → Oct 2020	—	Hospital General Universitario Elche	Unknown	No outcome recorded
Phase 3	NCT03876704	Jan → Sep 2019	anemia, bronchopulmonary dysplasia, infectious disease with sepsis, vitamin A deficiency +1	First Affiliated Hospital Xi'an Jiaotong University	Unknown	No outcome recorded
Phase 3	NCT03702374	Sep 2018 → Nov 2020	diabetic retinopathy	University of Guadalajara	Completed	No outcome recorded
Phase 3	NCT03557229	Jul 2018 → Jun 2022	disorder of defective peroxisome oxidative status, infectious disease with sepsis	American British Cowdray Medical Center	Unknown	No outcome recorded
Phase 3	NCT03443141	Jan → Mar 2018	—	Hospital General Universitario Elche	Unknown	No outcome recorded
Phase 3	NCT02842567	Apr 2017 → May 2018	fatty liver disease	Bambino Gesù Hospital and Research Institute	Completed	No outcome recorded
Phase 3	NCT02942498	Jul 2016 → Sep 2017	fragile X syndrome	Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud	Completed	No outcome recorded
Phase 3	NCT02629536	Mar 2016 → Mar 2017	migraine disorder	University of Notre Dame Australia	Unknown	No outcome recorded
Phase 3	NCT02554123	Jan → Sep 2015	—	Hospital General Universitario Elche	Completed	No outcome recorded
Phase 3	NCT02820948	Jan 2015 → Mar 2016	necrotizing soft tissue infection	Hospital General Universitario Elche	Completed	No outcome recorded
Phase 3	NCT01934777	Oct 2013 → Oct 2014	NAFLD1, abdominal obesity-metabolic syndrome, fibrotic liver disease, obesity disorder	Bambino Gesù Hospital and Research Institute	Completed	No outcome recorded
Phase 3	NCT00809458	Sep 2008 → May 2010	prostate cancer	New Mexico Cancer Research Alliance	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT00706121	Jun 2008 → Oct 2015	colorectal cancer, precancerous condition	SWOG Cancer Research Network	Completed	Missed primary
Phase 3	NCT00553124	Dec 2005 → ?	urinary bladder cancer	University Hospital Birmingham	Unknown	No outcome recorded
Phase 3	NCT00553345	Dec 2005 → ?	urinary bladder cancer	University of Birmingham	Unknown	No outcome recorded
Phase 3	NCT00063622	Jan 2005 → Jun 2009	liver disorder	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Completed	Mixed
Phase 3	NCT00784225	Jul 2004 → Nov 2017	cataract, macular degeneration	SWOG Cancer Research Network	Completed	Missed primary
Phase 3	NCT00116493	Apr 2004 → May 2007	anemia	Johns Hopkins Bloomberg School of Public Health	Completed	Missed primary
Phase 3	NCT00097110	Jul 2003 → Dec 2006	HELLP syndrome, eclampsia	NICHD Global Network for Women's and Children's Health	Completed	Missed primary
Phase 3	NCT00135707	Jun 2003 → Oct 2008	preeclampsia	The George Washington University Biostatistics Center	Completed	Missed primary
Phase 3	NCT00515736	Jan 2003 → Dec 2005	subarachnoid hemorrhage	Centre Hospitalier Universitaire Vaudois	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT00056329	Apr 2002 → May 2012	Alzheimer disease, Down syndrome	New York State Institute for Basic Research	Unknown	No outcome recorded
Phase 3	NCT00006392	Jul 2001 → May 2011	prostate cancer	SWOG Cancer Research Network	Completed	Missed primary
Phase 3	NCT00000173	Mar 1999 → Jan 2004	Alzheimer disease	National Institute on Aging (NIA)	Completed	No outcome recorded
Phase 3	NCT00000555	Aug 1996 → May 2003	coronary atherosclerosis, myocardial ischemia	National Heart, Lung, and Blood Institute (NHLBI)	Completed	No outcome recorded
Phase 3	NCT00000161	Aug 1993 → ?	age-related macular degeneration, cataract	National Eye Institute (NEI)	Unknown	Met primary
Phase 3	NCT00000539	Sep 1992 → Mar 1999	arterial occlusion, diabetes mellitus, heart disorder	National Heart, Lung, and Blood Institute (NHLBI)	Completed	No outcome recorded
Phase 3	NCT00000479	Sep 1992 → Mar 2004	cerebrovascular disorder, coronary artery disorder, myocardial infarction, myocardial ischemia	Brigham and Women's Hospital	Completed	No outcome recorded
Phase 3	NCT01437826	Mar 1988 → Jun 1996	colorectal adenoma	IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy	Terminated	No outcome recorded
Phase 3	NCT00000114	May 1984 → Jun 1987	retinitis pigmentosa	National Eye Institute (NEI)	Completed	No outcome recorded

Phase 412 trials · 2 met primary · 1 missed
Phase 4	NCT07466342	Jul 2025 → Jan 2026	primary dysmenorrhea	Nishtar Medical University	Completed	No outcome recorded
Phase 4	NCT05616442	May 2023 → Mar 2025	liver disorder	Tanta University	Completed	Met primary
Phase 4	NCT05984173	Jan → Dec 2022	alveolar periostitis	Ain Shams University	Completed	No outcome recorded
Phase 4	NCT05660694	Jan 2020 → Sep 2021	neoplasm, oral submucous fibrosis	Altamash Institute of Dental Medicine	Completed	No outcome recorded
Phase 4	NCT03358524	Sep 2017 → Feb 2018	—	Indonesia University	Completed	No outcome recorded
Phase 4	NCT03903133	Jun 2016 → May 2023	sickle cell disease	Ain Shams University	Completed	No outcome recorded
Phase 4	NCT01743742	May → Sep 2013	perinatal asphyxia	Sir Takhtasinhji General Hospital	Completed	Missed primary
Phase 4	NCT01148576	Jun 2010 → Dec 2011	chronic hepatitis B virus infection, fatty liver disease	Zhejiang University	Unknown	No outcome recorded
Phase 4	NCT01127282	Dec 2009 → Jun 2010	swine influenza	Seoul National University Hospital	Unknown	No outcome recorded
Phase 4	NCT00303160	Mar 2006 → Sep 2007	Helicobacter pylori infectious disease	University of Toronto	Unknown	No outcome recorded
Phase 4	NCT00384618	May 2001 → Aug 2005	chronic kidney disease	Amsterdam UMC, location VUmc	Terminated	Met primary
Phase 4	NCT00004637	—	epilepsy	National Center for Research Resources (NCRR)	Completed	No outcome recorded

Phase not applicable15 trials · 1 missed
—	NCT07301515	Mar → Nov 2025	hyperpigmentation of the skin, mitochondrial disease, radiation-induced disorder	Klira Skin	Completed	No outcome recorded
—	NCT07715643	Dec 2022 → Feb 2023	nephrolithiasis, calcium oxalate	University of Lahore	Completed	No outcome recorded
—	NCT05787925	Oct 2022 → Mar 2023	oral erosive lichen	Hams Hamed Abdelrahman	Completed	No outcome recorded
—	NCT06200584	Jan → Jun 2021	poisoning	Dr Rabia Arshad	Completed	No outcome recorded
—	NCT04570254	Aug → Dec 2020	COVID-19, acute respiratory distress syndrome, viral pneumonia	Unidad Temporal COVID-19 en Centro Citibanamex	Completed	No outcome recorded
—	NCT04000789	Jul → Dec 2019	dry eye syndrome, proliferative diabetic retinopathy	Dr Cipto Mangunkusumo General Hospital	Unknown	No outcome recorded
—	NCT03971604	Jan 2019 → Jan 2022	preeclampsia, vitamin A deficiency	Second Affiliated Hospital, School of Medicine, Zhejiang University	Unknown	No outcome recorded
—	NCT04640324	Jan → Oct 2017	NAFLD1	University of Campania Luigi Vanvitelli	Completed	No outcome recorded
—	NCT02962297	Dec 2016 → Nov 2020	metabolic dysfunction-associated steatohepatitis	Zhejiang Medicine Co., Ltd.	Completed	No outcome recorded
—	NCT01927679	Aug → Nov 2013	skin pigmentation disorder	Innovaderm Research Inc.	Completed	No outcome recorded
—	NCT01188005	Aug → Oct 2010	obstructive sleep apnea syndrome	University of Athens	Unknown	No outcome recorded
—	NCT01082003	Oct 2009 → Aug 2013	—	Legacy Health System	Unknown	No outcome recorded
—	NCT01597765	Jun 2009 → Jun 2011	thalassemia	Mahidol University	Completed	No outcome recorded
—	NCT00037063	—	HIV infectious disease	National Institute of Allergy and Infectious Diseases (NIAID)	Withdrawn	No outcome recorded
—	NCT00378456	—	trisomy 21	Institute of Child Health	Completed	Missed primary

Comparator or background therapy45 trials
Phase 0	NCT07121127 Background	Jul 2026 → Aug 2029 expected	age-related macular degeneration	Zhiming Yan	Not yet recruiting	No outcome recorded
Phase 0	NCT06105060 Comparator	Dec 2023 → Jun 2024	metabolic dysfunction-associated steatohepatitis	Beni-Suef University	Completed	No outcome recorded
Phase 1	NCT01578473 Comparator	May → Jul 2013	Peyronie disease	Men's Health Boston	Completed	No outcome recorded
Phase 1	NCT01700426 Comparator	Jun 2011 → Sep 2013	iron deficiency anemia	University of Colorado, Denver	Completed	No outcome recorded
Phase 1/2	NCT06871904 Background	Apr → Dec 2025	oral submucous fibrosis	Ziauddin University	Completed	No outcome recorded
Phase 1/2	NCT02181348 Comparator	Nov 2008 → Oct 2011	anemia	Aga Khan University	Completed	No outcome recorded
Phase 2	NCT07303803 Background	Jan 2026 → Dec 2030 expected	metabolic dysfunction-associated steatohepatitis, type 2 diabetes mellitus	Shanghai Jiao Tong University School of Medicine	Recruiting	No outcome recorded
Phase 2	NCT06321991 Comparator	Feb 2024 → Mar 2027 expected	palmar fibromatosis	Universitaire Ziekenhuizen KU Leuven	Recruiting	No outcome recorded
Phase 2	NCT04801849 Comparator	Aug 2022 → Mar 2025	NAFLD1, metabolic dysfunction-associated steatohepatitis	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Completed	No outcome recorded
Phase 2	NCT06677788 Comparator	Apr 2022 → Sep 2024	metabolic dysfunction-associated steatohepatitis	Tanta University	Completed	No outcome recorded
Phase 2	NCT05200663 Comparator	Oct 2021 → Oct 2022	oligoasthenoteratozoospermia	Sharif Medical Research Center	Unknown	No outcome recorded
Phase 2	NCT05573204 Comparator	Sep 2021 → Oct 2026 expected	metabolic dysfunction-associated steatohepatitis	Tanta University	Active not recruiting	No outcome recorded
Phase 2	NCT04071977 Comparator	Mar 2020 → Oct 2021	diabetes mellitus, diabetic retinopathy	University of Guadalajara	Completed	No outcome recorded
Phase 2	NCT03669133 Comparator	Oct 2019 → Mar 2021	HIV infectious disease, metabolic dysfunction-associated steatohepatitis	Indiana University	Terminated	No outcome recorded
Phase 2	NCT03968042 Background	Jun 2019 → Dec 2021	brain injury	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	Unknown	Mixed
Phase 2	NCT01792115 Comparator	May 2013 → Aug 2019	fatty liver disease	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Completed	No outcome recorded
Phase 2	NCT01897792 Comparator	May 2013 → Feb 2015	bacterial pneumonia, blood coagulation disease	University of Alabama at Birmingham	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT02058212 Comparator	Mar → Oct 2013	endometriosis	Cairo University	Completed	No outcome recorded
Phase 3	NCT07863648 Comparator	Oct 2026 → Aug 2027 expected	metabolic dysfunction-associated steatotic liver disease	Kafrelsheikh University	Not yet recruiting	No outcome recorded
Phase 3	NCT05906498 Comparator	Dec 2022 → Nov 2023	psoriasis	Badr University	Unknown	No outcome recorded
Phase 3	NCT04007874 Comparator	Sep 2019 → Dec 2024	migraine disorder	Leiden University Medical Center	Unknown	No outcome recorded
Phase 3	NCT03755700 Comparator	Nov 2018 → Dec 2019	acute coronary syndrome, coronary artery disorder	Rajaie Cardiovascular Medical and Research Center	Unknown	No outcome recorded
Phase 3	NCT02070679 Comparator	Feb 2014 → May 2015	acute subendocardial myocardial infarction, intermediate coronary syndrome	Urmia University of Medical Sciences	Completed	No outcome recorded
Phase 3	NCT02714543 Comparator	Nov 2013 → Aug 2015	oral submucous fibrosis	The Oxford Dental College, Hospital and Research Center, Bangalore, India	Completed	No outcome recorded
Phase 3	NCT01384578 Comparator	Jul 2011 → Nov 2013	metabolic dysfunction-associated steatohepatitis	Institute of Liver and Biliary Sciences, India	Withdrawn	No outcome recorded Stop: Business
Phase 3	NCT01266928 Comparator	Jan → Nov 2011	preterm premature rupture of the membranes	Erzincan Military Hospital	Completed	No outcome recorded
Phase 3	NCT01935817 Comparator	Jun 2010 → Dec 2012	fibrotic liver disease	University of Catania	Completed	No outcome recorded
Phase 3	NCT01957319 Comparator	Feb 2010 → Jul 2013	depressive disorder	University of Catania	Completed	No outcome recorded
Phase 3	NCT00740714 Background	Dec 2008 → Aug 2011	Parkinson disease	Weill Medical College of Cornell University	Terminated	Missed primary
Phase 3	NCT00211562 Comparator	Oct 2005 → Jan 2006	schizophrenia	Augusta University	Terminated	No outcome recorded
Phase 4	NCT07862725 Background	Oct 2026 → Oct 2027 expected	oligoasthenoteratozoospermia	Hamad Medical Corporation	Not yet recruiting	No outcome recorded
Phase 4	NCT06926712 Comparator	Jun 2025 → Jun 2026 overdue	respiratory system disorder	Assiut University	Not yet recruiting	No outcome recorded
Phase 4	NCT04977661 Comparator	Feb → May 2020	metabolic dysfunction-associated steatohepatitis	Kafrelsheikh University	Completed	No outcome recorded
Phase 4	NCT03176966 Comparator	Sep 2016 → Oct 2021	cirrhosis of liver	Vanderbilt University Medical Center	Completed	No outcome recorded
Phase 4	NCT01720719 Comparator	May 2013 → Dec 2016	diabetes mellitus, fatty liver disease, hyperlipidemia	Xin Gao	Unknown	No outcome recorded
Phase 4	NCT00431691 Comparator	Sep 2006 → Dec 2007	escherichia coli infection, retinal disorder	Medical University of Vienna	Completed	No outcome recorded
—	NCT07391267 Background	Feb 2026 → Dec 2028 expected	chronic kidney disease, metabolic dysfunction-associated steatotic liver disease	Institute of Liver and Biliary Sciences, India	Not yet recruiting	No outcome recorded
—	NCT05410093 Comparator	Feb 2022 → Jul 2024	primary ovarian failure	Affiliated Hospital of Nantong University	Unknown	No outcome recorded
—	NCT06274216 Comparator	Sep 2021 → Mar 2022	—	Ziauddin University	Completed	No outcome recorded
—	NCT04664010 Background	Feb 2020 → Sep 2022	COVID-19	Xi'an International Medical Center Hospital	Completed	No outcome recorded
—	NCT04463459 Comparator	Oct 2019 → Jul 2020	breast cancer	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	Unknown	No outcome recorded
—	NCT03659058 Comparator	Mar 2016 → Aug 2018	fibrotic liver disease	Zagazig University	Completed	No outcome recorded
—	NCT03274596 Comparator	Mar 2013 → Oct 2015	retinopathy of prematurity	Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes	Completed	No outcome recorded
—	NCT01279434 Comparator	Jan → Mar 2012	metabolic dysfunction-associated steatohepatitis	Institute of Liver and Biliary Sciences, India	Withdrawn	No outcome recorded
—	NCT00914576 Comparator	Apr 2011 → Jul 2013	—	Medical University of Vienna	Completed	No outcome recorded

News releases announcing trial results or a regulatory action · 1

Date	Issuer	Release
2022-08-08	Otsuka Pharmaceutical Development & Commercialization, Inc.	Results Presentation of Research Regarding Compounds Contributing to Alleviation of Premenstrual Symptoms otsuka.co.jp ↗ It has been suggested that supplementation of γ-tocopherol (γ-Toc), γ-tocotrienol (γ-TT), equol (EQL) and calcium (Ca) may effectively relieve physical (water retention, etc.) and psychological (irritability, etc.) PMS symptoms.

All press releases naming this drug 1 release

Date	Issuer	Release
2022-08-08	Otsuka Pharmaceutical Development & Commercialization, Inc.	Presentation of Research Regarding Compounds Contributing to Alleviation of Premenstrual Symptoms otsuka.co.jp ↗

Evidence & citations 16 cited values

Every value below carries the sentence it was read from. 152 sources stand behind the page.

Field	Value	Cited text
Known as	vitamin E	“with daily multivitamins [vitamin A (300 microg, as retinol palmitate), vitamin E (6 mg tocopherol equivalents), vitamin B-12 (0.9 microg), vitamin C (15 mg), riboflavin (0.5...” PMID 19535425 ↗ Jun 2009 147 “Fat-soluble vitamins is administered 0.5 piece/kg (equals to 1150 U/kg vitamin A，200 U/kg vitamin D, 3.2 U/kg vitamin E) intravenously every day until the baby achieve full...” NCT03876704 ↗ “Vitamin C (1,000 mg i.v.) and Vitamin E (1,000 IU p.o. via the naso-gastric tube) administered every 8 hours starting within one hour after admission to the Emergency...” NCT01897792 ↗ “total daily dose label claim: micronutrient combination of 500 mg vitamin C (magnesium ascorbate), 315 mg magnesium (magnesium citrate, magnesium ascorbate, magnesium...” NCT00808470 ↗ “It consists in a tablet with lutein (10 mg), astaxanthin (4 mg), Zeaxanthin (1mg), vitamin C (L-ascorbic acid 180mg), vitamin E (DL-alpha tocopherol 30mg), zinc (zinc oxide...” NCT03702374 ↗ “Anti-oxidants such as N-acetylcysteine (NAc), Vitamin C (ascorbic acid) (VitC) and Vitamin E (alpha-tocopherol) (VitE) are potent FRS 'scavengers', which means they could be...” NCT02629536 ↗ “SM Fibro (Alpha lipoic acid 50mg, Beta-carotene 10mg, Elemental copper 1mg, Elemental selenium 75mcg, Lycopene 5mg, Vitamin E 10 IU, Zinc sulphate 27.45mg in form of the...” NCT02714543 ↗ “Tablet: Vitamin C, 500 mg; Vitamin D3, 1000 IU; Vitamin E, 400 IU; Folic Acid 1000 mcg; Zinc, 20 mg; Selenium 200 mcg; Lycopene, 10 mg; Capsule: Vitamin D3, 1000 IU,...” NCT02421887 ↗ “The purpose of this pilot study is to investigate the possibility that H.pylori infection alters the bioavailability of the dietary antioxidants: vitamin C, and vitamin E.” NCT00303160 ↗ “(1 mg copper, 20 mg zinc, 180 mg vitamin C, 30 mg vitamin E, 1 mg zeaxanthin, 4 mg astaxanthin, 10 mg lutein) daily of oral, all of them in one Tablet for 24 weeks” NCT02062034 ↗ “combined with an antioxidant complex composed of Phytexcell Liquorice extract (Glycyrrhiza glabra), Resveratrol bioferment, and Vitamin E (tocopherol)” NCT07301515 ↗ Show 137 more sources
Known as	Alfa-Tocoferol	“Effects of Vitamin E (Alfa-Tocoferol) Supplementation” NCT03358524 ↗
Known as	all rac-α-tocopheryl acetate	“Individual supplements of selenium (200 μg per day from L-selenomethionine) and vitamin E (400 IU per day of all rac-α-tocopheryl acetate).” PMID 25232809 ↗ Jan 2015
Known as	alpha tocopherol	“We plan to test the efficacy of alpha-tocopherol (vitamin E), a potent inhibitor of the protein kinase C pathway in vascular endothelial growth factor (VEGF) induced vascular...” NCT00021645 ↗ 3 “Vitamin E (alpha-tocopherol) is thought to have antioxidant properties, and was shown in a 1997 study to delay important dementia milestones, such as patients'...” NCT00000173 ↗ “Anti-oxidants such as N-acetylcysteine (NAc), Vitamin C (ascorbic acid) (VitC) and Vitamin E (alpha-tocopherol) (VitE) are potent FRS 'scavengers', which means they could be...” NCT02629536 ↗ “Vitamin-E capsule (alpha tocopherol) 400 IU (once per day)” NCT03358524 ↗
Known as	DL-alpha tocopherol	“It consists in a tablet with lutein (10 mg), astaxanthin (4 mg), Zeaxanthin (1mg), vitamin C (L-ascorbic acid 180mg), vitamin E (DL-alpha tocopherol 30mg), zinc (zinc oxide...” NCT03702374 ↗ 1 “vitamin E (DL-alpha tocopherol 30 mg)” NCT04071977 ↗
Known as	RRR alpha tocopherol acetate	“capsules containing a combination of 1,000 mg vitamin C (ascorbic acid) and 400 international units of vitamin E (RRR alpha tocopherol acetate)” NCT01266928 ↗
Known as	rrr- -tocopherol	“Following that, all patients will be randomized to treatment with 3 different doses of natural vitamin E (rrr- -tocopherol at 200, 400 or 800 IU/d) for 24 weeks.” NCT01792115 ↗
Known as	tocopherol	“Vitamin E (tocopherol)” NCT07301515 ↗
Known as	Tocopherol Acetate	“• Vitamin E (Tocopherol Acetate): This intervention uses vitamin E, another antioxidant, thought to reduce inflammation and support tissue repair, potentially improving the...” NCT06847880 ↗
Known as	Vit E	“Anti-oxidants such as N-acetylcysteine (NAc), Vitamin C (ascorbic acid) (VitC) and Vitamin E (alpha-tocopherol) (VitE) are potent FRS 'scavengers', which means they could be...” NCT02629536 ↗ 4 “Existing clinical trials on omega-3 and vitamin E (Vit E) are sometimes questioned due to using omega-6 fatty acids as placebo and neglecting omega-6 fatty acid intake in the diet.” NCT00399282 ↗ “We recently reported that Hydroxytyrosol (HXT) and Vitamin E (VitE) may improve oxidative stress, insulin resistance, and steatosis in children with biopsy-proven NAFLD.” PMID 33060043 ↗ Oct 2020 “Group 1 received vitamin C (Vit C), Group 2 vitamin E (Vit E), Group 3 n-acetylcysteine (NAC), Group 4 melatonin (MT) and group 5 no treatment.” PMID 37174730 ↗ May 2023 “Drug: Vit E” NCT05573204 ↗
Known as	vitamin E 400 IU/day brand name Natural	“vitamin E 400 IU/day brand name Natural” NCT01597765 ↗
Known as	Vitamin E [(all-rac)-α-tocopheryl acetate]	“Vitamin E [(all-rac)-α-tocopheryl acetate]” NCT04198805 ↗
Known as	α-tocopherol	“Treatment with vitamin E (α-tocopherol, αT), a lipid-soluble antioxidant, improves liver injury but also decreases steatosis, thought to be upstream of OS, through an unknown mechanism.” PMID 32920226 ↗ Sep 2020 2 “To investigate whether selenium and/or vitamin E (α-tocopherol) supplementation reduces the risk of recurrence and progression.” NCT00553345 ↗ “800 IU/d of vitamin E (α-tocopherol)” PMID 22431837 ↗ Jul 2012
Action	Inhibit	“vitamin E inhibits GDH activity” NCT04984798 ↗
Modality	Other / unclassified	“antioxidant supplementation with vitamins C and E” PMID 20375405 ↗ Apr 2010
Route	Oral	“daily treatment with oral high-dose vitamin E (1600 units) or placebo” NCT00021645 ↗