First-day High Dose Vitamin C, E in Severe Birth Asphyxia

Summary

To study the role of first-day high dose oral vitamin C and first-day single high dose oral vitamin E in hypoxic-ischemic encephalopathy in newborns, in the reduction of morbidity and adverse neurodevelopmental sequelae.

Timeline

Start

2013-05

Primary completion

2013-09

Completion

2013-10

Outcome

Missed primary endpoint

paper There were no significant differences in primary outcomes between the groups. PMID 15724034 ↗

Publications

• Results Darlow BA, Buss H, McGill F, Fletcher L, Graham P, Winterbourn CC. Vitamin C supplementation in very preterm infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2005 Mar;90(2):F117-22. doi: 10.1136/adc.2004.056440.

Drugs

Indications