Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy

NCT02062034 ↗

Phase 2 Completed 61 enrolled University of Guadalajara Instituto Mexicano del Seguro Social · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to evaluate the efficacy of ubiquinone and combined antioxidant therapy on progression, clinical regression, oxidative stress markers and mitochondrial dysfunction in non-proliferative diabetic retinopathy.

Timeline

Start: 2011-02
Primary completion: 2013-11
Completion: 2014-01

Publications

Results Hernandez-Ojeda J, Cardona-Munoz EG, Roman-Pintos LM, Troyo-Sanroman R, Ortiz-Lazareno PC, Cardenas-Meza MA, Pascoe-Gonzalez S, Miranda-Diaz AG. The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study. J Diabetes Complications. 2012 Jul-Aug;26(4):352-8. doi: 10.1016/j.jdiacomp.2012.04.004. Epub 2012 May 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Astaxanthin	Small molecule	4 mg	Oral
Subject	Coenzyme Q10	Other / unclassified	400 mg	Oral
Subject	Copper	Unknown	1 mg	Oral
Subject	Lutein	Other / unclassified	10 mg	Oral
Subject	Vitamin C	Other / unclassified	180 mg	Oral
Subject	Vitamin E	Other / unclassified	30 mg	Oral
Subject	Zeaxanthin	Small molecule	1 mg	Oral
Subject	Zinc Sulfate	Unknown	20 mg	Oral

Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy

Summary

Timeline

Publications

Drugs

Indications