Zinc Sulfate

also known as Zinc · zinc sulphate · zinc acetate · Zinc citrate · zinc chloride · NPC-02 · ZnCl2 · Galzin (zinc acetata, Teva Pharmaceuticals) · +6 more

Developed for: pneumonia · diarrheal disease · acute diarrhea · COVID-19 · disorder of zinc metabolism · mucositis · respiratory tract infectious disorder · sickle cell disease
+85 more
· hyperbilirubinemia · infectious disease with sepsis · male infertility · Wilson disease · cardiomyopathy · cholera · gingivitis · HIV infectious disease · lichen planus, oral · tuberculosis · type 2 diabetes mellitus · alcoholic hepatitis · amyotrophic lateral sclerosis · androgenetic alopecia · autism spectrum disorder · benign essential blepharospasm · bronchiolitis · central serous chorioretinopathy · cervical dystonia · chemotherapy-induced oral mucositis · childhood onset asthma · chronic kidney disease · chronic periodontitis · clonic hemifacial spasm · colorectal adenoma · congenital nonhemolytic jaundice · congestive heart failure · cystic fibrosis · dentin sensitivity · developmental and epileptic encephalopathy, 17 · developmental disability · diabetic retinopathy · disease related to hematopoietic stem cell transplant · dystonic disorder · eating disorder · female breast carcinoma · fetal growth restriction · food protein-induced allergic proctocolitis · gastroenteritis · geographic tongue · heart failure · hyperlipidemia · idiopathic pulmonary fibrosis · infectious disease · infertility disorder · intestinal infectious disease · melanoma · mouth disorder · nephrotic syndrome of childhood - steroid sensitive · neural tube defect · neurodevelopmental disorder with involuntary movements · nutritional deficiency disease · nutritional disorder · oral sensibility, disturbance of · overactive bladder · poliomyelitis · pregnancy disorder · primary bacterial infectious disease · protein-energy malnutrition · rosacea · thalassemia · tinnitus · triple-negative breast carcinoma · trisomy 21 · typhoid fever · viral respiratory tract infection · visceral leishmaniasis · aphthous stomatitis · beta-thalassemia major · bronchopulmonary dysplasia · chronic hepatitis C virus infection · end stage renal failure · endometriosis · fibrotic liver disease · Helicobacter pylori infectious disease · infectious disorder of the nervous system · influenza · intestinal fistula · major depressive disorder · necrotizing enterocolitis · neonatal sepsis · oral submucous fibrosis · retinal disorder · retinopathy of prematurity · skin disorder caused by infection
Investigated by: International Centre for Diarrhoeal Disease Research, Bangladesh · Society for Applied Studies · All India Institute of Medical Sciences · World Health Organization · Bill and Melinda Gates Foundation · Centre For International Health
+172 more
· Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Nobelpharma · Ain Shams University · Johns Hopkins Bloomberg School of Public Health · Ministry of Health, Saudi Arabia · National Institute of Allergy and Infectious Diseases (NIAID) · United States Agency for International Development (USAID) · Arak University of Medical Sciences · Cairo University · Centers for Disease Control and Prevention · Colgate Palmolive · HALEON · Makerere University · Mansoura University · Muhammad Aamir Latif · St. Francis Hospital, New York · Statens Serum Institut · Thrasher Research Fund · Tribhuvan University, Nepal · University of California, San Francisco · University of Michigan · University of Pennsylvania · Access to Advanced Health Institute (AAHI) · Aga Khan University · Alcon Research · American Society of Hematology · Amira Adel Fouly · Ankara City Hospital Bilkent · Annamalai University · Arkansas Children's Hospital Research Institute · Augusta University · Azienda Ospedaliero, Universitaria Pisana · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · Baylor College of Medicine · Beni-Suef University · Benisuef university hospital · Boston Children's Hospital · Canadian Institutes of Health Research (CIHR) · Cedars-Sinai Medical Center · Center for Studies of Sensory Impairment, Aging and Metabolism · Children's Hospital Los Angeles · Children's Hospital Medical Center, Cincinnati · Children's Hospital of Fudan University · Children's Hospital of Michigan · Children's Hospital of Philadelphia · Children's National Research Institute · Children's University Hospital Cologne, Germany · Chittagong Medical College · Corporacion Ecuatoriana de Biotecnologia · Cystic Fibrosis Foundation · Dow University of Health Sciences · Duke University · Egyptian Chinese University · Emory University · Endeavor Health · Essentia Health · European Commission · FISABIO Foundation · Faculty of Medicine, University of Indonesia · Federal University of Rio Grande do Sul · Fogarty International Center of the National Institute of Health · Foundation for Alimentation and Nutrition, Central America and Panama · GlaxoSmithKline · Global Health Uganda LTD · Global Network for Women's and Children's Health Research · Grey's Hospital · Göteborg University · Hams Hamed Abdelrahman · Harborview Injury Prevention and Research Center · Harvard School of Public Health (HSPH) · Hasanuddin University · Health Canada · Hormozgan University of Medical Sciences · Hospital General de Mexico · all 178 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	ZINC CHLORIDE IN PLASTIC CONTAINER	—	1986-06-26	fda.gov ↗

Trials 123 · started per year

today

US approved 1986

1986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 02 trials
Phase 0	NCT05680662	Jan → Dec 2023	female breast carcinoma, triple-negative breast carcinoma	Ministry of Health, Saudi Arabia	Unknown	No outcome recorded
Phase 0	NCT05178953	Aug 2021 → Jan 2022	male infertility	Arak University of Medical Sciences	Unknown	No outcome recorded
Phase 15 trials
Phase 1	NCT05116098	Nov 2021 → Jun 2022	tuberculosis	Ministry of Health, Saudi Arabia	Unknown	No outcome recorded
Phase 1	NCT03690583	Jan 2014 → Feb 2016	pneumonia	Universidad Nacional Autonoma de Mexico	Completed	No outcome recorded
Phase 1	NCT00696410	Jun 2008 → Jun 2011	cardiomyopathy, heart failure	University of Michigan	Completed	No outcome recorded
Phase 1	NCT01062347	Jul 2007 → Dec 2010	disorder of zinc metabolism	International Centre for Diarrhoeal Disease Research, Bangladesh	Completed	No outcome recorded
Phase 1	NCT00278681	Aug 2003 → Aug 2004	acute diarrhea	Society for Applied Studies	Completed	No outcome recorded
Phase 1/23 trials
Phase 1/2	NCT01662089	Jan → Oct 2012	androgenetic alopecia	Siriraj Hospital	Unknown	No outcome recorded
Phase 1/2	NCT01259050	Oct 2010 → Jan 2012	amyotrophic lateral sclerosis	Phoenix Neurological Associates, LTD	Completed	No outcome recorded
Phase 1/2	NCT01019083	Feb 2008 → Dec 2010	cholera, typhoid fever	International Centre for Diarrhoeal Disease Research, Bangladesh	Completed	No outcome recorded
Phase 219 trials
Phase 2	NCT07140874	Jun 2026 → May 2027 expected	cervical dystonia	University of Florida	Recruiting	No outcome recorded
Phase 2	NCT07405554	Feb → Dec 2026 expected	overactive bladder	Endeavor Health	Recruiting	No outcome recorded
Phase 2	NCT06260891	Feb 2026 → Jul 2027 expected	sickle cell disease	University of California, San Francisco	Recruiting	No outcome recorded
Phase 2	NCT06567717	Nov 2025 → Jan 2027 expected	idiopathic pulmonary fibrosis	Cedars-Sinai Medical Center	Recruiting	No outcome recorded
Phase 2	NCT07102836	Aug 2025 → Feb 2026 overdue	hyperbilirubinemia	Quaid-e-Azam Medical College	Recruiting	No outcome recorded
Phase 2	NCT06412653	Aug 2024 → Aug 2025	developmental and epileptic encephalopathy, 17, developmental disability, dystonic disorder, neurodevelopmental disorder with involuntary movements	Children's University Hospital Cologne, Germany	Completed	No outcome recorded
Phase 2	NCT06482034	Jun 2023 → Sep 2024	mucositis	Mansoura University	Completed	No outcome recorded
Phase 2	NCT04898023	Sep 2022 → Oct 2023	viral respiratory tract infection	University of Missouri-Columbia	Terminated	No outcome recorded
Phase 2	NCT05395143	May 2021 → Jul 2022	hyperlipidemia	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	Unknown	No outcome recorded
Phase 2	NCT02421887	Dec 2015 → Jun 2018	male infertility	Yale University	Completed	No outcome recorded
Phase 2	NCT03159845	Jan 2014 → Sep 2019	disease related to hematopoietic stem cell transplant	Azienda Ospedaliero, Universitaria Pisana	Completed	No outcome recorded
Phase 2	NCT02062034	Feb 2011 → Nov 2013	diabetic retinopathy, type 2 diabetes mellitus	University of Guadalajara	Completed	No outcome recorded
Phase 2	NCT01140074	Jul 2010 → Jun 2012	acute diarrhea	University Hospital No 1 Wroclaw	Unknown	No outcome recorded
Phase 2	NCT00878605	Apr 2010 → Jun 2013	type 2 diabetes mellitus	VA Office of Research and Development	Terminated	No outcome recorded
Phase 2	NCT02101008	Mar 2010 → Feb 2013	melanoma	University of Utah	Completed	No outcome recorded
Phase 2	NCT00683644	Jan 2008 → Dec 2011	tinnitus	University of Iowa	Completed	No outcome recorded
Phase 2	NCT00963131	Dec 2004 → Dec 2008	central serous chorioretinopathy	Prince of Songkla University	Completed	No outcome recorded
Phase 2	NCT00138047	Mar 2003 → Sep 2004	HIV infectious disease	Johns Hopkins Bloomberg School of Public Health	Completed	No outcome recorded
Phase 2	NCT00133419	? → Jan 2006	intestinal infectious disease	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded

Phase 2/311 trials
Phase 2/3	NCT06561061	Feb → Nov 2025	sickle cell disease	Indiana University	Completed	No outcome recorded
Phase 2/3	NCT04959786	Apr 2021 → Nov 2022	pneumonia	Mansoura University	Unknown	No outcome recorded
Phase 2/3	NCT04301336	Nov 2019 → Nov 2020	sickle cell disease	Beni-Suef University	Completed	No outcome recorded
Phase 2/3	NCT02868151	Aug 2016 → Dec 2017	mucositis	Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre	Completed	No outcome recorded
Phase 2/3	NCT04574544	Mar → Dec 2015	—	University of Douala	Completed	No outcome recorded
Phase 2/3	NCT01809132	Sep 2013 → Oct 2018	alcoholic hepatitis	Mack Mitchell	Completed	No outcome recorded
Phase 2/3	NCT01015183	Nov 2009 → Nov 2010	mucositis	Tehran University of Medical Sciences	Completed	No outcome recorded
Phase 2/3	NCT00252304	Jan 2006 → Jul 2008	pneumonia	Centre For International Health	Completed	No outcome recorded
Phase 2/3	NCT00347386	Jul 2005 → Dec 2008	infectious disease with sepsis, pneumonia, primary bacterial infectious disease	Centre For International Health	Completed	No outcome recorded
Phase 2/3	NCT00148733	Jan 2004 → Jan 2008	pneumonia	Centre For International Health	Completed	No outcome recorded
Phase 2/3	NCT00370968	Sep 2003 → Dec 2006	acute diarrhea	Centre For International Health	Completed	No outcome recorded

Phase 331 trials
Phase 3	NCT07664592	Jun → Jul 2026 overdue	dentin sensitivity	Colgate Palmolive	Recruiting	No outcome recorded
Phase 3	NCT07398378	Jun → Jul 2026 overdue	mouth disorder	Colgate Palmolive	Active not recruiting	No outcome recorded
Phase 3	NCT06433674	Jun 2024 → Jul 2025	nutritional deficiency disease	University of Tennessee	Unknown	No outcome recorded
Phase 3	NCT05614349	Jan 2023 → Apr 2025 overdue	COVID-19	Unity Health Toronto	Active not recruiting	No outcome recorded
Phase 3	NCT06869798	Sep 2021 → Oct 2022	childhood onset asthma	King Edward Medical University	Completed	No outcome recorded
Phase 3	NCT04447534	Jun → Jul 2020	COVID-19	Tanta University	Completed	No outcome recorded
Phase 3	NCT04446104	May → Aug 2020	COVID-19	National University Hospital, Singapore	Completed	No outcome recorded
Phase 3	NCT06227624	Jun 2018 → Jun 2019	congenital nonhemolytic jaundice	National Liver Institute, Egypt	Completed	No outcome recorded
Phase 3	NCT03824925	Dec 2016 → Oct 2018	oral sensibility, disturbance of	Dow University of Health Sciences	Completed	No outcome recorded
Phase 3	NCT02321865	Jan → Nov 2015	disorder of zinc metabolism	Nobelpharma	Completed	No outcome recorded
Phase 3	NCT02337569	Jan → Nov 2015	disorder of zinc metabolism	Nobelpharma	Completed	No outcome recorded
Phase 3	NCT00801606	Dec 2008 → Jun 2012	tuberculosis	All India Institute of Medical Sciences	Completed	No outcome recorded
Phase 3	NCT00530829	Oct 2007 → Apr 2009	diarrheal disease	Centers for Disease Control and Prevention	Completed	No outcome recorded
Phase 3	NCT00421668	Sep 2007 → Oct 2012	diarrheal disease, respiratory tract infectious disorder	Harvard School of Public Health (HSPH)	Completed	No outcome recorded
Phase 3	NCT00395161	Apr 2007 → Nov 2009	infectious disease with sepsis	Michael Dean	Terminated	No outcome recorded
Phase 3	NCT00373100	Sep 2006 → Mar 2007	pneumonia	Makerere University	Completed	No outcome recorded
Phase 3	NCT00133406	Jun 2006 → Dec 2011	diarrheal disease	University of Virginia	Unknown	No outcome recorded
Phase 3	NCT00536133	Apr 2006 → May 2008	respiratory tract infectious disorder	Jawaharlal Nehru Medical College	Completed	No outcome recorded
Phase 3	NCT00355043	Feb 2006 → Sep 2007	bronchiolitis	International Centre for Diarrhoeal Disease Research, Bangladesh	Completed	No outcome recorded
Phase 3	NCT00133432	Sep 2005 → ?	pneumonia	National Institute of Allergy and Infectious Diseases (NIAID)	Terminated	No outcome recorded
Phase 3	NCT00212355	Mar 2005 → Apr 2008	Wilson disease	Nobelpharma	Completed	No outcome recorded
Phase 3	NCT00325247	Feb 2005 → May 2006	acute diarrhea	International Centre for Diarrhoeal Disease Research, Bangladesh	Completed	No outcome recorded
Phase 3	NCT00408356	Nov 2004 → Aug 2006	acute diarrhea	International Centre for Diarrhoeal Disease Research, Bangladesh	Completed	No outcome recorded
Phase 3	NCT00142285	Nov 2004 → May 2006	pneumonia	International Centre for Diarrhoeal Disease Research, Bangladesh	Completed	No outcome recorded
Phase 3	NCT00212368	Oct 2004 → Aug 2005	Wilson disease	Nobelpharma	Completed	No outcome recorded
Phase 3	NCT00098202	Mar 2003 → Apr 2007	pregnancy disorder	NICHD Global Network for Women's and Children's Health	Completed	No outcome recorded
Phase 3	NCT00255385	Apr 2002 → Apr 2004	diarrheal disease, pneumonia	Johns Hopkins Bloomberg School of Public Health	Completed	No outcome recorded
Phase 3	NCT00109551	Oct 2001 → Jan 2006	—	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Completed	No outcome recorded
Phase 3	NCT00226616	Nov 2000 → Jul 2002	cholera	International Centre for Diarrhoeal Disease Research, Bangladesh	Completed	No outcome recorded
Phase 3	NCT00321126	Jan 1999 → Apr 2002	—	International Centre for Diarrhoeal Disease Research, Bangladesh	Completed	No outcome recorded
Phase 3	NCT01437826	Mar 1988 → Jun 1996	colorectal adenoma	IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy	Terminated	No outcome recorded

Phase 414 trials
Phase 4	NCT06517862	Sep 2024 → Jun 2026 overdue	hyperbilirubinemia	Amira Adel Fouly	Recruiting	No outcome recorded
Phase 4	NCT05190562	Sep 2021 → Jan 2022	geographic tongue	mariam hamouda	Completed	No outcome recorded
Phase 4	NCT04621461	Dec 2020 → Feb 2021	COVID-19	St. Francis Hospital, New York	Completed	No outcome recorded
Phase 4	NCT04468139	Jun → Jul 2020	COVID-19	Ministry of Health, Saudi Arabia	Unknown	No outcome recorded
Phase 4	NCT04370782	Apr → Sep 2020	COVID-19	St. Francis Hospital, New York	Completed	No outcome recorded
Phase 4	NCT04278599	Jan → Sep 2020	lichen planus, oral	Postgraduate Institute of Dental Sciences Rohtak	Unknown	No outcome recorded
Phase 4	NCT05002101	Aug 2018 → Aug 2019	disorder of zinc metabolism, nutritional disorder	Ain Shams University	Completed	No outcome recorded
Phase 4	NCT03098810	Apr → Sep 2017	eating disorder	Ain Shams University	Unknown	No outcome recorded
Phase 4	NCT05311540	Mar 2014 → Mar 2015	disorder of zinc metabolism	Zekai Tahir Burak Women's Health Research and Education Hospital	Completed	No outcome recorded
Phase 4	NCT03117192	Sep 2013 → Feb 2014	thalassemia	Faculty of Medicine, University of Indonesia	Completed	No outcome recorded
Phase 4	NCT01475227	Dec 2011 → Mar 2012	HIV infectious disease	St Stephens Aids Trust	Completed	No outcome recorded
Phase 4	NCT00449592	Apr 2007 → Sep 2008	mucositis	Sheba Medical Center	Completed	No outcome recorded
Phase 4	NCT00228254	Jan 2000 → Jun 2004	diarrheal disease, pneumonia	Tufts University	Completed	No outcome recorded
Phase 4	NCT00004338	Oct 1993 → ?	Wilson disease	National Center for Research Resources (NCRR)	Completed	No outcome recorded

Phase not applicable38 trials
—	NCT07509918	Sep → Oct 2026 expected	—	Cairo University	Not yet recruiting	No outcome recorded
—	NCT07538999	Apr 2026 → Dec 2027 expected	—	Children's Hospital of Fudan University	Recruiting	No outcome recorded
—	NCT07383363	Sep 2025 → Mar 2026	autism spectrum disorder	Muhammad Aamir Latif	Completed	No outcome recorded
—	NCT07169188	Sep → Dec 2025	gingivitis	HALEON	Completed	No outcome recorded
—	NCT06673082	Dec 2024 → Apr 2025 overdue	food protein-induced allergic proctocolitis	Kasr El Aini Hospital	Enrolling by invitation	No outcome recorded
—	NCT06602466	Sep → Dec 2024	gingivitis	HALEON	Completed	No outcome recorded
—	NCT06847139	Jul 2024 → Jul 2025 overdue	chronic kidney disease	Chittagong Medical College	Recruiting	No outcome recorded
—	NCT06556511	Feb → May 2024	infectious disease with sepsis	dr. Aldora Jesslyn Oentari	Completed	No outcome recorded
—	NCT06860620	Jan → Dec 2024	nephrotic syndrome of childhood - steroid sensitive	Muhammad Aamir Latif	Completed	No outcome recorded
—	NCT06042010	Jan → Feb 2023	lichen planus, oral	Hams Hamed Abdelrahman	Completed	No outcome recorded
—	NCT05156684	Jan 2022	infertility disorder	Arak University of Medical Sciences	Unknown	No outcome recorded
—	NCT05161611	Dec 2021 → Aug 2022	hyperbilirubinemia	Makassed General Hospital	Completed	No outcome recorded
—	NCT04935515	Apr → May 2021	COVID-19	Manimarane Arjunan, MD,DM (Cardiology)	Completed	No outcome recorded
—	NCT05543603	Apr 2021 → Jan 2022	COVID-19	FISABIO Foundation	Completed	No outcome recorded
—	NCT06042738	Mar → Nov 2021	male infertility	Ondokuz Mayıs University	Completed	No outcome recorded
—	NCT04039828	Sep 2019 → Mar 2020	acute diarrhea	International Centre for Diarrhoeal Disease Research, Bangladesh	Completed	No outcome recorded
—	NCT04321850	Jun 2019 → Jun 2020	chemotherapy-induced oral mucositis	National Institute of Pediatrics, Mexico	Terminated	No outcome recorded
—	NCT03923829	Apr 2019 → Aug 2020	chronic periodontitis	Cairo University	Unknown	No outcome recorded
—	NCT03293641	May 2016 → Jan 2017	disorder of zinc metabolism, infectious disease, sickle cell disease	Lucas Otieno Tina, MD MSc	Completed	No outcome recorded
—	NCT02351687	Apr 2014 → Jun 2016	protein-energy malnutrition	Washington University School of Medicine	Completed	No outcome recorded
—	NCT01857310	Jun 2013 → Jun 2019	pregnancy disorder with abortive outcome	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Completed	No outcome recorded
—	NCT01546805	Apr → Dec 2012	benign essential blepharospasm, clonic hemifacial spasm	St. Joseph's Healthcare Hamilton	Unknown	No outcome recorded
—	NCT01198587	Nov 2010 → Jun 2014	acute diarrhea, gastroenteritis	Boston Children's Hospital	Completed	No outcome recorded
—	NCT01229579	May 2010 → Jan 2011	poliomyelitis	Aga Khan University	Completed	No outcome recorded
—	NCT01474486	Apr 2010 → Feb 2016	cardiomyopathy, congestive heart failure	Phoenix VA Health Care System	Completed	No outcome recorded
—	NCT01069198	Oct 2009 → Oct 2010	visceral leishmaniasis	International Centre for Diarrhoeal Disease Research, Bangladesh	Completed	No outcome recorded
—	NCT01306097	Jan 2009 → Jan 2010	diarrheal disease	Hormozgan University of Medical Sciences	Completed	No outcome recorded
—	NCT00395226	Jul 2006 → Jul 2008	rosacea	Essentia Health	Terminated	No outcome recorded
—	NCT00394862	Jan → Jun 2006	neural tube defect	Emory University	Completed	No outcome recorded
—	NCT00272142	Jan 2005 → Aug 2007	diarrheal disease, fetal growth restriction, respiratory tract infectious disorder	Society for Applied Studies	Completed	No outcome recorded
—	NCT00278746	Jan 2005 → Sep 2006	acute diarrhea	Society for Applied Studies	Completed	No outcome recorded
—	NCT00104494	May 2004 → Sep 2007	cystic fibrosis	Cystic Fibrosis Foundation	Completed	No outcome recorded
—	NCT00399256	Mar 2004 → Mar 2006	chronic renal failure syndrome	Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)	Terminated	No outcome recorded
—	NCT00198666	Sep 2003 → Aug 2004	pneumonia	Johns Hopkins Bloomberg School of Public Health	Completed	No outcome recorded
—	NCT00269542	Feb 2002 → Mar 2003	diarrheal disease, pneumonia	Society for Applied Studies	Completed	No outcome recorded
—	NCT00272116	Feb 1998 → Feb 2000	diarrheal disease, pneumonia	Society for Applied Studies	Completed	No outcome recorded
—	NCT00374023	Jul 1993 → Nov 1995	diarrheal disease, respiratory tract infectious disorder	International Centre for Diarrhoeal Disease Research, Bangladesh	Completed	No outcome recorded
—	NCT00378456	—	trisomy 21	Institute of Child Health	Completed	No outcome recorded

Also used as a comparator or background therapy in 40 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 01 trial
Phase 0	NCT06588036 Comparator	Sep → Dec 2024 overdue	—	Combined Military Hospital Multan	Not yet recruiting	No outcome recorded
Phase 13 trials
Phase 1	NCT05670444 Comparator	Jan → Feb 2023	influenza	Hôpital Universitaire Sahloul	Completed	No outcome recorded
Phase 1	NCT05104424 Comparator	Dec 2021 → Aug 2022	olfactory nerve disorder, oral sensibility, disturbance of	Ministry of Health, Saudi Arabia	Unknown	No outcome recorded
Phase 1	NCT00325572 Comparator	Nov 2006 → Dec 2010	autism spectrum disorder	Milton S. Hershey Medical Center	Terminated	No outcome recorded
Phase 1/24 trials
Phase 1/2	NCT05453227 Comparator	Dec 2021 → Dec 2022	—	Egymedicalpedia	Completed	No outcome recorded
Phase 1/2	NCT04472585 Comparator	Nov 2020 → Aug 2021	COVID-19	Sohaib Ashraf	Unknown	No outcome recorded
Phase 1/2	NCT04591600 Background	Jul → Sep 2020	COVID-19	Alkarkh Health Directorate-Baghdad	Completed	No outcome recorded
Phase 1/2	NCT01062009 Comparator	Nov 2008 → Oct 2014	—	UCSF Benioff Children's Hospital Oakland	Completed	No outcome recorded
Phase 28 trials
Phase 2	NCT07145268 Comparator	Sep 2025 → Sep 2026 expected	fibrotic liver disease, hepatitis B virus infection	Tanta University	Not yet recruiting	No outcome recorded
Phase 2	NCT05398965 Background	Nov 2020 → Jan 2021	COVID-19	Hasanuddin University	Completed	No outcome recorded
Phase 2	NCT04072822 Comparator	Jul 2020 → May 2022	alcoholic hepatitis	Indiana University	Completed	No outcome recorded
Phase 2	NCT05366595 Comparator	Jul 2019 → Jun 2022	—	Mansoura University	Completed	No outcome recorded
Phase 2	NCT03135522 Comparator	Feb 2018 → Dec 2019	—	Johns Hopkins University	Completed	No outcome recorded
Phase 2	NCT02058212 Comparator	Mar → Oct 2013	endometriosis	Cairo University	Completed	No outcome recorded
Phase 2	NCT01210014 Comparator	Apr 2008 → Apr 2009	aphthous stomatitis	Qazvin University Of Medical Sciences	Completed	No outcome recorded
Phase 2	NCT00210470 Background	Jul 2005 → Dec 2010	head and neck squamous cell carcinoma	Brooklyn ImmunoTherapeutics, LLC	Completed	No outcome recorded

Phase 2/31 trial
Phase 2/3	NCT05463484 Comparator	Jul 2021 → Feb 2023	mouth disorder	Mucosa Innovations, S.L.	Completed	No outcome recorded
Phase 310 trials
Phase 3	NCT07275827 Comparator	Feb → Apr 2026 overdue	Helicobacter pylori infectious disease	Tanta University	Not yet recruiting	No outcome recorded
Phase 3	NCT05465434 Comparator	Aug 2022 → Jan 2023	chronic hepatitis C virus infection	Tanta University	Completed	No outcome recorded
Phase 3	NCT05047523 Comparator	Sep 2021 → Jun 2023	Wilson disease	Alexion Pharmaceuticals, Inc.	Terminated	No outcome recorded
Phase 3	NCT04189367 Background	Jun 2020 → Jul 2022	burning mouth syndrome	Chang Gung Memorial Hospital	Unknown	No outcome recorded
Phase 3	NCT04810728 Background	Jun → Dec 2020	COVID-19	Baiturrahmah University	Completed	No outcome recorded
Phase 3	NCT04377646 Comparator	May 2020	COVID-19	Military Hospital of Tunis	Unknown	No outcome recorded
Phase 3	NCT03158168 Comparator	Mar 2018 → Jun 2019	skin disorder caused by infection	Assiut University	Unknown	No outcome recorded
Phase 3	NCT03403205 Comparator	Feb 2018 → Jun 2023	Wilson disease	Alexion Pharmaceuticals, Inc.	Terminated	No outcome recorded
Phase 3	NCT03851055 Comparator	Aug 2017 → Jul 2018	beta-thalassemia major	Ain Shams University	Completed	No outcome recorded
Phase 3	NCT02714543 Comparator	Nov 2013 → Aug 2015	oral submucous fibrosis	The Oxford Dental College, Hospital and Research Center, Bangalore, India	Completed	No outcome recorded

Phase 46 trials
Phase 4	NCT05677126 Comparator	Aug 2024	—	American Regent, Inc.	Withdrawn	No outcome recorded
Phase 4	NCT06151392 Comparator	Jul 2023 → Dec 2025 overdue	infectious disorder of the nervous system	Ain Shams University	Recruiting	No outcome recorded
Phase 4	NCT04050488 Comparator	Aug 2019 → Jul 2020	bronchopulmonary dysplasia, fetal growth restriction, necrotizing enterocolitis, neonatal sepsis +1	Faculty of Medicine, University of Indonesia	Unknown	No outcome recorded
Phase 4	NCT03005496 Comparator	Jan → Apr 2017	—	Indonesia University	Completed	No outcome recorded
Phase 4	NCT01571856 Comparator	Jul 2011 → Jul 2012	acute diarrhea, gastroenteritis	Centro Pediatrico Albina de Patino	Completed	No outcome recorded
Phase 4	NCT00431691 Comparator	Sep 2006 → Dec 2007	escherichia coli infection, retinal disorder	Medical University of Vienna	Completed	No outcome recorded

Phase not applicable7 trials
—	NCT06009744 Comparator	Aug 2023 → Dec 2028 expected	intestinal fistula	Hospital Juarez de Mexico	Recruiting	No outcome recorded
—	NCT06540209 Background	Apr → Sep 2023	acute diarrhea	RESnTEC, Institute of Research	Completed	No outcome recorded
—	NCT05930002 Comparator	Jul 2021 → Sep 2022	COVID-19	Ain Shams University	Completed	No outcome recorded
—	NCT04482296 Comparator	Sep 2019 → Jul 2020	major depressive disorder	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	Completed	No outcome recorded
—	NCT00914576 Comparator	Apr 2011 → Jul 2013	—	Medical University of Vienna	Completed	No outcome recorded
—	NCT01101217 Comparator	Feb → Sep 2009	end stage renal failure	Shiraz University of Medical Sciences	Completed	No outcome recorded
—	NCT00682955 Comparator	Aug 2007 → Apr 2008	acute diarrhea	Aga Khan University	Completed	No outcome recorded

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 167 sources stand behind the page.

Field	Value	Cited text
Known as	zinc sulfate	“The intervention was delivered most commonly in the form of syrup as zinc sulfate, and the most common dose was between 10 mg and 15 mg daily.” PMID 36994923 ↗ Mar 2023 39 “The intervention was delivered most commonly in the form of syrup as zinc sulfate, and the most common dose was between 10 mg and 15 mg daily.” PMID 36994923 ↗ Mar 2023 “daily zinc sulfate (20 mg/day) for two weeks prior to immunization and until the last follow-up for sample collection” NCT01019083 ↗ “50 mg/day of zinc sulfate in addition to the standard direct-acting antiviral therapy for the same duration.” PMID 39789197 ↗ Jan 2025 “Zinc Sulfate (Zn SO4) one tablet daily at bedtime which provides 50 mg elemental zinc (220 mg Zn SO4)” NCT01474486 ↗ “Zinc Sulfate Tablets” NCT03293641 ↗ NCT04039828 ↗ NCT03158168 ↗ NCT06561061 ↗ NCT05190562 ↗ NCT01229579 ↗ NCT07102836 ↗ NCT07275827 ↗ NCT07383363 ↗ NCT05395143 ↗ NCT01140074 ↗ NCT04301336 ↗ NCT06847139 ↗ NCT03824925 ↗ NCT04370782 ↗ NCT06517862 ↗ NCT01198587 ↗ NCT04050488 ↗ NCT05366595 ↗ NCT06482034 ↗ NCT03159845 ↗ NCT05178953 ↗ NCT06433674 ↗ NCT03923829 ↗ NCT06556511 ↗ NCT04482296 ↗ NCT01809132 ↗ NCT06227624 ↗ NCT03690583 ↗ NCT05311540 ↗ NCT03117192 ↗ NCT01062009 ↗ NCT01571856 ↗ NCT01015183 ↗ NCT00395226 ↗
Known as	Galzin (zinc acetata, Teva Pharmaceuticals)	“Galzin (zinc acetata, Teva Pharmaceuticals)” NCT00696410 ↗
Known as	NPC-02	ClinicalTrials.gov intervention name — accepted as the source's own label NCT02321865 ↗ 1 NCT02337569 ↗
Known as	Solvazinc	“Zinc sulphate 125mg (1 Solvazinc tablet) once daily orally after dissolution in water, day 2 to day 15” NCT01475227 ↗
Known as	Zinc	“This standard treatment is personalized according to the severity but is not limited to standard antiviral therapy, azithromycin 500 mg a day, vitamin C 500 mg 8 hourly a day,...” NCT05398965 ↗ 97 “food supplement containing 2000 mg L-carnitine, 2000 mg fructose, 932 mg acetyl L-carnitine, 225 mg vitamin C, 115 mg citric acid, 50 mg coenzyme Q10, 14 mg zinc, 115 µg...” NCT06042738 ↗ “Depending on the site/region, participants randomized to receive Standard of Care treatment will receive trientine, penicillamine, zinc, or a combination of these medicines,...” NCT05047523 ↗ “a Cyclo-Z capsule containing Cyclo-His Pro (CHP) 0 (placebo), 3 mg (minimally effective), 9 mg (optimally effective), or 15 mg (no-additional effect) plus 20 mg zinc on...” NCT00878605 ↗ “Depending on the site/region, participants randomized to receive SoC treatment will receive trientine, penicillamine, Zinc, or a combination of these medicines, administered...” NCT03403205 ↗ “Tablet: Vitamin C, 500 mg; Vitamin D3, 1000 IU; Vitamin E, 400 IU; Folic Acid 1000 mcg; Zinc, 20 mg; Selenium 200 mcg; Lycopene, 10 mg; Capsule: Vitamin D3, 1000 IU,...” NCT02421887 ↗ “The second therapeutic arm investigates a combination antioxidant therapy (selenium 300 µg, zinc 40 mg, lycopene 45 mg and vitamin C 1.5 g), administered for 10 days.” PMID 40754325 ↗ Aug 2025 “(1 mg copper, 20 mg zinc, 180 mg vitamin C, 30 mg vitamin E, 1 mg zeaxanthin, 4 mg astaxanthin, 10 mg lutein) daily of oral, all of them in one Tablet for 24 weeks” NCT02062034 ↗ “The treatment group received two pills in the morning containing Vit C Vit D zinc and minerals and one pill of 2 mg of melatonin in the evening” NCT05670444 ↗ “Nutritional supplement: vitamin B12, folic acid, iron, zinc, vitamin B complex depending on the hematic deficiency, for 12 weeks” NCT04189367 ↗ “Zinc, a micronutrient, appears to have anti-viral properties with various mechanisms of action depending on the concentration” NCT04621461 ↗ “(Vitamin C, Zinc, medication for clinical symptoms such as: antipyretic agent, decongestan and mucolytic.)” NCT04810728 ↗ “containing: Lutein 12mg, Vitamin C 300mg, Zinc 10mg, Ginko Biloba 10mg, Flavonoids 25mg, Fish oil 300mg” NCT00914576 ↗ “The zinc syrup was prepared with a concentration of 7 mg zinc in each 5 ml solution.” NCT05002101 ↗ “5 mg folic acid and 30 mg elemental zinc, taken orally, daily for 6 months.” NCT01857310 ↗ “Oral Azithromycin , Cetirizine, Paracetamol, Zinc, Vitamin C, Vitamin D” NCT04935515 ↗ “Intervention Name: Zinc sulfate Other Intervention Names: Zinc” NCT06482034 ↗ “different levels of folic acid, Vitamin B12, iron and zinc” NCT00394862 ↗ “Group 1 receiving zinc and probiotic supplementation” NCT06588036 ↗ “zinc sulfate 220 mg per day orally for 6 weeks” NCT01101217 ↗ “Zinc 75mg tablet once daily for two weeks” NCT05930002 ↗ “early enteral zinc supplementation” NCT07538999 ↗ “zinc 50 mg orally daily” NCT05104424 ↗ “Zinc 75-125 mg/day” NCT04591600 ↗ “zinc 17.4mg” NCT00431691 ↗ “zinc 60 mg” NCT00963131 ↗ “30 mg zinc” NCT01437826 ↗ NCT04446104 ↗ NCT02058212 ↗ NCT07145268 ↗ NCT00138047 ↗ NCT00374023 ↗ NCT00098202 ↗ NCT00278746 ↗ NCT01259050 ↗ NCT04278599 ↗ NCT01069198 ↗ NCT06151392 ↗ NCT00421668 ↗ NCT05677126 ↗ NCT00801606 ↗ NCT00449592 ↗ NCT04447534 ↗ NCT03851055 ↗ NCT00104494 ↗ NCT06260891 ↗ NCT00255385 ↗ NCT00272142 ↗ NCT06869798 ↗ NCT04472585 ↗ NCT01662089 ↗ NCT05680662 ↗ NCT04072822 ↗ NCT00370968 ↗ NCT00148733 ↗ NCT00252304 ↗ NCT00269542 ↗ NCT00325572 ↗ NCT00198666 ↗ NCT06009744 ↗ NCT05161611 ↗ NCT00228254 ↗ NCT00210470 ↗ NCT00272116 ↗ NCT00133432 ↗ NCT00683644 ↗ NCT00536133 ↗ NCT02351687 ↗ NCT00408356 ↗ NCT00325247 ↗ NCT00133419 ↗ NCT00133406 ↗ NCT06042010 ↗ NCT01546805 ↗ NCT04377646 ↗ NCT00399256 ↗ NCT00347386 ↗ NCT00278681 ↗ NCT00378456 ↗ NCT00321126 ↗ NCT06673082 ↗ NCT05116098 ↗ NCT06567717 ↗ NCT07140874 ↗ NCT05156684 ↗ NCT05453227 ↗ NCT04468139 ↗ NCT03005496 ↗ NCT02101008 ↗ NCT01062347 ↗ NCT04959786 ↗ NCT06860620 ↗ NCT04321850 ↗ NCT00395161 ↗ NCT06540209 ↗ NCT00109551 ↗ NCT00226616 ↗ NCT00530829 ↗
Known as	zinc acetate	“In this study, the authors used zinc acetate to treat Japanese patients with Wilson disease and investigated its efficacy.” PMID 21078496 ↗ Sep 2010 7 NCT00004338 ↗ NCT07509918 ↗ NCT00696410 ↗ NCT00212368 ↗ NCT02868151 ↗ NCT03135522 ↗ NCT00373100 ↗
Known as	Zinc Acetate Dihydrate	ClinicalTrials.gov intervention name — accepted as the source's own label NCT06412653 ↗
Known as	zinc chloride	“0.454% Stannous Fluoride, 0.3% Zinc Chloride,1% Alumina toothpaste containing 1100 parts per million (ppm) fluoride.” NCT06602466 ↗ 2 “Toothpaste containing 0.454% SnF2, 0.3% zinc chloride (ZnCl2) and 1% alumina.” NCT07169188 ↗ “15 ml 0,10% cymenol + 0,10% zinc chloride, one minute rinse” NCT05543603 ↗
Known as	Zinc citrate	“Compounded capsules containing each zinc citrate, green tea extract, and ascorbic acid.” NCT04898023 ↗ 4 “Commercial Fluoridated toothpaste for gingivitis with zinc citrate.” NCT05463484 ↗ “Drug: Zinc citrate” NCT07140874 ↗ “0.5% zinc citrate” NCT07398378 ↗ NCT07405554 ↗
Known as	Zinc Phosphate	“A commercially available fluoride toothpaste containing 8% arginine + Zinc Phosphate” NCT07664592 ↗
Known as	Zinc Sulfate, generic	“Zinc Sulfate, generic” NCT01809132 ↗
Known as	zinc sulphate	“SM Fibro (Alpha lipoic acid 50mg, Beta-carotene 10mg, Elemental copper 1mg, Elemental selenium 75mcg, Lycopene 5mg, Vitamin E 10 IU, Zinc sulphate 27.45mg in form of the...” NCT02714543 ↗ 14 “second group (n = 27) was on OHA and in addition 50 mg elemental zinc as zinc sulphate supplementation for 12 weeks” PMID 24082728 ↗ Jul 2013 “The 25 supplemented children had received an oral dose of 10 mg of zinc sulphate per day for 14 days” NCT04574544 ↗ “Zinc sulphate 125mg, day 2 to day 15” NCT01475227 ↗ “Drug: Zinc (zinc sulphate)” NCT00347386 ↗ “Zinc (zinc sulphate)” NCT00252304 ↗ “Zinc (zinc sulphate)” NCT07145268 ↗ “Drug: zinc sulphate” NCT06869798 ↗ “Zinc sulphate 50 mg” NCT05465434 ↗ NCT01019083 ↗ NCT03098810 ↗ NCT00142285 ↗ NCT00355043 ↗ NCT01210014 ↗ NCT00682955 ↗
Known as	Zn SO4	“Zinc Sulfate (Zn SO4) one tablet daily at bedtime which provides 50 mg elemental zinc (220 mg Zn SO4)” NCT01474486 ↗
Known as	Zn sulfate	“Neonates will receive oral Zn sulfate solution in either low doses (10 mg/day) or high doses (20 mg/day) given twice daily.” NCT06517862 ↗
Known as	ZnCl2	“0.454 percent (%) Stannous Fluoride (SnF2), 0.3% Zinc Chloride (ZnCl2) and 1% Alumina” NCT06602466 ↗ 1 “Toothpaste containing 0.454% SnF2, 0.3% zinc chloride (ZnCl2) and 1% alumina.” NCT07169188 ↗
Action	Activate	“MTT is an endogenous antioxidant that can be induced by both zinc (Zn) and ischemia.” PMID 28302075 ↗ Mar 2017
Modality	Other / unclassified	“micronutrients (especially of zinc and iron)” PMID 20730057 ↗ Aug 2010
Route	Oral	“They will be instructed to take 1 mL of the solution twice daily for two months.” NCT00104494 ↗