Drugs / Zinc Sulfate
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Zinc Sulfate

Developed for
pneumonia · diarrheal disease · acute diarrhea · COVID-19 · disorder of zinc metabolism · mucositis · respiratory tract infectious disorder · sickle cell disease
+88 more · gingivitis · hyperbilirubinemia · infectious disease with sepsis · male infertility · Wilson disease · cardiomyopathy · cholera · HIV infectious disease · lichen planus, oral · tuberculosis · type 2 diabetes mellitus · alcoholic hepatitis · amyotrophic lateral sclerosis · androgenetic alopecia · autism spectrum disorder · benign essential blepharospasm · bronchiolitis · central serous chorioretinopathy · cervical dystonia · chemotherapy-induced oral mucositis · childhood onset asthma · chronic kidney disease · chronic periodontitis · clonic hemifacial spasm · colorectal adenoma · congenital nonhemolytic jaundice · congestive heart failure · cystic fibrosis · dentin sensitivity · developmental and epileptic encephalopathy, 17 · developmental disability · diabetic retinopathy · disease related to hematopoietic stem cell transplant · dystonic disorder · eating disorder · female breast carcinoma · fetal growth restriction · food protein-induced allergic proctocolitis · gastroenteritis · geographic tongue · heart failure · hepatocellular carcinoma · hyperlipidemia · idiopathic pulmonary fibrosis · infectious disease · infertility disorder · intestinal infectious disease · melanoma · mouth disorder · nephrotic syndrome of childhood - steroid sensitive · neural tube defect · neurodevelopmental disorder with involuntary movements · nutritional deficiency disease · nutritional disorder · oral sensibility, disturbance of · overactive bladder · poliomyelitis · pregnancy disorder · primary bacterial infectious disease · protein-energy malnutrition · rosacea · thalassemia · tinnitus · triple-negative breast carcinoma · trisomy 21 · typhoid fever · viral respiratory tract infection · visceral leishmaniasis · aphthous stomatitis · beta-thalassemia major · bronchopulmonary dysplasia · chronic hepatitis C virus infection · end stage renal failure · endometriosis · fibrotic liver disease · Helicobacter pylori infectious disease · infectious disorder of the nervous system · influenza · intestinal fistula · major depressive disorder · necrotizing enterocolitis · neonatal sepsis · oral submucous fibrosis · plantar wart · retinal disorder · retinopathy of prematurity · skin disorder caused by infection · ulcerative colitis
Investigated by
International Centre for Diarrhoeal Disease Research, Bangladesh · Society for Applied Studies · All India Institute of Medical Sciences · World Health Organization · Bill and Melinda Gates Foundation · Centre For International Health
+175 more · Colgate Palmolive · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Nobelpharma · Ain Shams University · Johns Hopkins Bloomberg School of Public Health · Ministry of Health, Saudi Arabia · National Institute of Allergy and Infectious Diseases (NIAID) · United States Agency for International Development (USAID) · Arak University of Medical Sciences · Cairo University · Centers for Disease Control and Prevention · HALEON · Makerere University · Mansoura University · Muhammad Aamir Latif · St. Francis Hospital, New York · Statens Serum Institut · Thrasher Research Fund · Tribhuvan University, Nepal · University of California, San Francisco · University of Michigan · University of Pennsylvania · Access to Advanced Health Institute (AAHI) · Aga Khan University · Alcon Research · American Society of Hematology · Amira Adel Fouly · Anhui Provincial Hospital · Ankara City Hospital Bilkent · Annamalai University · Arkansas Children's Hospital Research Institute · Augusta University · Azienda Ospedaliero, Universitaria Pisana · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · Baylor College of Medicine · Beni-Suef University · Benisuef university hospital · Boston Children's Hospital · Canadian Institutes of Health Research (CIHR) · Cedars-Sinai Medical Center · Center for Studies of Sensory Impairment, Aging and Metabolism · Children's Hospital Los Angeles · Children's Hospital Medical Center, Cincinnati · Children's Hospital of Fudan University · Children's Hospital of Michigan · Children's Hospital of Philadelphia · Children's National Research Institute · Children's University Hospital Cologne, Germany · Chittagong Medical College · Corporacion Ecuatoriana de Biotecnologia · Cystic Fibrosis Foundation · Dow University of Health Sciences · Duke University · Egyptian Chinese University · Emory University · Endeavor Health · Essentia Health · European Commission · FENO.Co · FISABIO Foundation · Faculty of Medicine, University of Indonesia · Federal University of Rio Grande do Sul · Fogarty International Center of the National Institute of Health · Foundation for Alimentation and Nutrition, Central America and Panama · GlaxoSmithKline · Global Health Uganda LTD · Global Network for Women's and Children's Health Research · Grey's Hospital · Göteborg University · Hams Hamed Abdelrahman · Harborview Injury Prevention and Research Center · Harvard School of Public Health (HSPH) · Hasanuddin University · Health Canada · all 181 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) ZINC CHLORIDE IN PLASTIC CONTAINER — 1986-06-26 fda.gov ↗

Trials 126 · started per year

today
US approved 1986
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT05680662 Jan → Dec 2023 female breast carcinoma, triple-negative breast carcinoma Ministry of Health, Saudi Arabia Unknown No outcome recorded
Phase 0 NCT05178953 Aug 2021 → Jan 2022 male infertility Arak University of Medical Sciences Unknown No outcome recorded
Phase 15 trials
Phase 1 NCT05116098 Nov 2021 → Jun 2022 tuberculosis Ministry of Health, Saudi Arabia Unknown No outcome recorded
Phase 1 NCT03690583 Jan 2014 → Feb 2016 pneumonia Universidad Nacional Autonoma de Mexico Completed No outcome recorded
Phase 1 NCT00696410 Jun 2008 → Jun 2011 cardiomyopathy, heart failure University of Michigan Completed No outcome recorded
Phase 1 NCT01062347 Jul 2007 → Dec 2010 disorder of zinc metabolism International Centre for Diarrhoeal Disease Research, Bangladesh Completed No outcome recorded
Phase 1 NCT00278681 Aug 2003 → Aug 2004 acute diarrhea Society for Applied Studies Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT01662089 Jan → Oct 2012 androgenetic alopecia Siriraj Hospital Unknown No outcome recorded
Phase 1/2 NCT01259050 Oct 2010 → Jan 2012 amyotrophic lateral sclerosis Phoenix Neurological Associates, LTD Completed No outcome recorded
Phase 1/2 NCT01019083 Feb 2008 → Dec 2010 cholera, typhoid fever International Centre for Diarrhoeal Disease Research, Bangladesh Completed No outcome recorded
Phase 220 trials · 2 missed
Phase 2 NCT07793695 Sep 2026 → Aug 2027 expected hepatocellular carcinoma Anhui Provincial Hospital Recruiting No outcome recorded
Phase 2 NCT07140874 Jun 2026 → May 2027 expected cervical dystonia University of Florida Recruiting No outcome recorded
Phase 2 NCT07405554 Feb → Dec 2026 expected overactive bladder Endeavor Health Recruiting No outcome recorded
Phase 2 NCT06260891 Feb 2026 → Jul 2027 expected sickle cell disease University of California, San Francisco Recruiting No outcome recorded
Phase 2 NCT06567717 Nov 2025 → Jan 2027 expected idiopathic pulmonary fibrosis Cedars-Sinai Medical Center Recruiting No outcome recorded
Phase 2 NCT07102836 Aug 2025 → Feb 2026 overdue hyperbilirubinemia Quaid-e-Azam Medical College Recruiting No outcome recorded
Phase 2 NCT06412653 Aug 2024 → Aug 2025 developmental and epileptic encephalopathy, 17, developmental disability, dystonic disorder, neurodevelopmental disorder with involuntary movements Children's University Hospital Cologne, Germany Completed No outcome recorded
Phase 2 NCT06482034 Jun 2023 → Sep 2024 mucositis Mansoura University Completed No outcome recorded
Phase 2 NCT04898023 Sep 2022 → Oct 2023 viral respiratory tract infection University of Missouri-Columbia Terminated No outcome recorded Stop: Business
Phase 2 NCT05395143 May 2021 → Jul 2022 hyperlipidemia Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Unknown No outcome recorded
Phase 2/311 trials · 1 met primary · 4 missed
Phase 2/3 NCT06561061 Feb → Nov 2025 sickle cell disease Indiana University Completed No outcome recorded
Phase 2/3 NCT04959786 Apr 2021 → Nov 2022 pneumonia Mansoura University Unknown No outcome recorded
Phase 2/3 NCT04301336 Nov 2019 → Nov 2020 sickle cell disease Beni-Suef University Completed No outcome recorded
Phase 2/3 NCT02868151 Aug 2016 → Dec 2017 mucositis Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre Completed No outcome recorded
Phase 2/3 NCT04574544 Mar → Dec 2015 — University of Douala Completed No outcome recorded
Phase 2/3 NCT01809132 Sep 2013 → Oct 2018 alcoholic hepatitis Mack Mitchell Completed Missed primary
Phase 2/3 NCT01015183 Nov 2009 → Nov 2010 mucositis Tehran University of Medical Sciences Completed No outcome recorded
Phase 2/3 NCT00252304 Jan 2006 → Jul 2008 pneumonia Centre For International Health Completed Missed primary
Phase 2/3 NCT00347386 Jul 2005 → Dec 2008 infectious disease with sepsis, pneumonia, primary bacterial infectious disease Centre For International Health Completed Met primary
Phase 2/3 NCT00148733 Jan 2004 → Jan 2008 pneumonia Centre For International Health Completed Missed primary
Phase 332 trials · 2 met primary · 7 missed
Phase 3 NCT07664592 Jun → Jul 2026 overdue dentin sensitivity Colgate Palmolive Recruiting No outcome recorded
Phase 3 NCT07398378 Jun → Jul 2026 overdue mouth disorder Colgate Palmolive Active not recruiting No outcome recorded
Phase 3 NCT06433674 Jun 2024 → Jul 2025 nutritional deficiency disease University of Tennessee Unknown No outcome recorded
Phase 3 NCT05614349 Jan 2023 → Apr 2025 overdue COVID-19 Unity Health Toronto Active not recruiting Missed primary
Phase 3 NCT06479226 Jun → Oct 2022 — Colgate Palmolive Completed No outcome recorded
Phase 3 NCT06869798 Sep 2021 → Oct 2022 childhood onset asthma King Edward Medical University Completed Met primary
Phase 3 NCT04447534 Jun → Jul 2020 COVID-19 Tanta University Completed Missed primary
Phase 3 NCT04446104 May → Aug 2020 COVID-19 National University Hospital, Singapore Completed No outcome recorded
Phase 3 NCT06227624 Jun 2018 → Jun 2019 congenital nonhemolytic jaundice National Liver Institute, Egypt Completed No outcome recorded
Phase 3 NCT03824925 Dec 2016 → Oct 2018 oral sensibility, disturbance of Dow University of Health Sciences Completed No outcome recorded
Phase 415 trials · 1 met primary
Phase 4 NCT07807397 Sep 2026 → Sep 2027 expected dental caries, gingivitis Colgate Palmolive Not yet recruiting No outcome recorded
Phase 4 NCT06517862 Sep 2024 → Mar 2026 hyperbilirubinemia Amira Adel Fouly Completed No outcome recorded
Phase 4 NCT05190562 Sep 2021 → Jan 2022 geographic tongue mariam hamouda Completed No outcome recorded
Phase 4 NCT04621461 Dec 2020 → Feb 2021 COVID-19 St. Francis Hospital, New York Completed No outcome recorded
Phase 4 NCT04468139 Jun → Jul 2020 COVID-19 Ministry of Health, Saudi Arabia Unknown No outcome recorded
Phase 4 NCT04370782 Apr → Sep 2020 COVID-19 St. Francis Hospital, New York Completed No outcome recorded
Phase 4 NCT04278599 Jan → Sep 2020 lichen planus, oral Postgraduate Institute of Dental Sciences Rohtak Unknown No outcome recorded
Phase 4 NCT05002101 Aug 2018 → Aug 2019 disorder of zinc metabolism, nutritional disorder Ain Shams University Completed Met primary
Phase 4 NCT03098810 Apr → Sep 2017 eating disorder Ain Shams University Unknown No outcome recorded
Phase 4 NCT05311540 Mar 2014 → Mar 2015 disorder of zinc metabolism Zekai Tahir Burak Women's Health Research and Education Hospital Completed No outcome recorded
Phase not applicable38 trials · 6 missed
— NCT07509918 Sep → Oct 2026 expected — Cairo University Not yet recruiting No outcome recorded
— NCT07538999 Apr 2026 → Dec 2027 expected — Children's Hospital of Fudan University Recruiting No outcome recorded
— NCT07383363 Sep 2025 → Mar 2026 autism spectrum disorder Muhammad Aamir Latif Completed No outcome recorded
— NCT07169188 Sep → Dec 2025 gingivitis HALEON Completed No outcome recorded
— NCT06673082 Dec 2024 → Apr 2025 overdue food protein-induced allergic proctocolitis Kasr El Aini Hospital Enrolling by invitation No outcome recorded
— NCT06602466 Sep → Dec 2024 gingivitis HALEON Completed Missed primary
— NCT06847139 Jul 2024 → Jul 2025 overdue chronic kidney disease Chittagong Medical College Recruiting No outcome recorded
— NCT06556511 Feb → May 2024 infectious disease with sepsis dr. Aldora Jesslyn Oentari Completed No outcome recorded
— NCT06860620 Jan → Dec 2024 nephrotic syndrome of childhood - steroid sensitive Muhammad Aamir Latif Completed No outcome recorded
— NCT06042010 Jan → Feb 2023 lichen planus, oral Hams Hamed Abdelrahman Completed No outcome recorded
Comparator or background therapy43 trials
Phase 0 NCT06588036 Comparator Sep → Dec 2024 overdue — Combined Military Hospital Multan Not yet recruiting No outcome recorded
Phase 1 NCT05670444 Comparator Jan → Feb 2023 influenza Hôpital Universitaire Sahloul Completed No outcome recorded
Phase 1 NCT05104424 Comparator Dec 2021 → Aug 2022 olfactory nerve disorder, oral sensibility, disturbance of Ministry of Health, Saudi Arabia Unknown No outcome recorded
Phase 1 NCT00325572 Comparator Nov 2006 → Dec 2010 autism spectrum disorder Milton S. Hershey Medical Center Terminated No outcome recorded
Phase 1/2 NCT05453227 Comparator Dec 2021 → Dec 2022 — Egymedicalpedia Completed No outcome recorded

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 173 sources stand behind the page.

FieldValueCited text
Known as zinc sulfate “The intervention was delivered most commonly in the form of syrup as zinc sulfate, and the most common dose was between 10 mg and 15 mg daily.” PMID 36994923 ↗ Mar 2023
39

“The intervention was delivered most commonly in the form of syrup as zinc sulfate, and the most common dose was between 10 mg and 15 mg daily.” PMID 36994923 ↗ Mar 2023

“daily zinc sulfate (20 mg/day) for two weeks prior to immunization and until the last follow-up for sample collection” NCT01019083 ↗

“50 mg/day of zinc sulfate in addition to the standard direct-acting antiviral therapy for the same duration.” PMID 39789197 ↗ Jan 2025

“Zinc Sulfate (Zn SO4) one tablet daily at bedtime which provides 50 mg elemental zinc (220 mg Zn SO4)” NCT01474486 ↗

“Zinc Sulfate Tablets” NCT03293641 ↗

NCT06517862 ↗

NCT05311540 ↗

NCT06227624 ↗

NCT06482034 ↗

NCT03117192 ↗

Show 29 more sources

Known as Galzin (zinc acetata, Teva Pharmaceuticals) “Galzin (zinc acetata, Teva Pharmaceuticals)” NCT00696410 ↗
Known as NPC-02 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02337569 ↗
1

NCT02321865 ↗

Known as Solvazinc “Zinc sulphate 125mg (1 Solvazinc tablet) once daily orally after dissolution in water, day 2 to day 15” NCT01475227 ↗
Known as Zinc “This standard treatment is personalized according to the severity but is not limited to standard antiviral therapy, azithromycin 500 mg a day, vitamin C 500 mg 8 hourly a day,...” NCT05398965 ↗
102

“food supplement containing 2000 mg L-carnitine, 2000 mg fructose, 932 mg acetyl L-carnitine, 225 mg vitamin C, 115 mg citric acid, 50 mg coenzyme Q10, 14 mg zinc, 115 µg...” NCT06042738 ↗

“Depending on the site/region, participants randomized to receive Standard of Care treatment will receive trientine, penicillamine, zinc, or a combination of these medicines,...” NCT05047523 ↗

“a Cyclo-Z capsule containing Cyclo-His Pro (CHP) 0 (placebo), 3 mg (minimally effective), 9 mg (optimally effective), or 15 mg (no-additional effect) plus 20 mg zinc on...” NCT00878605 ↗

“Depending on the site/region, participants randomized to receive SoC treatment will receive trientine, penicillamine, Zinc, or a combination of these medicines, administered...” NCT03403205 ↗

“Tablet: Vitamin C, 500 mg; Vitamin D3, 1000 IU; Vitamin E, 400 IU; Folic Acid 1000 mcg; Zinc, 20 mg; Selenium 200 mcg; Lycopene, 10 mg; Capsule: Vitamin D3, 1000 IU,...” NCT02421887 ↗

“The second therapeutic arm investigates a combination antioxidant therapy (selenium 300 µg, zinc 40 mg, lycopene 45 mg and vitamin C 1.5 g), administered for 10 days.” PMID 40754325 ↗ Aug 2025

“(1 mg copper, 20 mg zinc, 180 mg vitamin C, 30 mg vitamin E, 1 mg zeaxanthin, 4 mg astaxanthin, 10 mg lutein) daily of oral, all of them in one Tablet for 24 weeks” NCT02062034 ↗

“Participants will receive antioxidant therapy consisting of vitamin C 1000 mg/day, vitamin E 400 IU/day, L-carnitine, and zinc 25 mg/day for 6 months.” NCT07862725 ↗

“The treatment group received two pills in the morning containing Vit C Vit D zinc and minerals and one pill of 2 mg of melatonin in the evening” NCT05670444 ↗

“Nutritional supplement: vitamin B12, folic acid, iron, zinc, vitamin B complex depending on the hematic deficiency, for 12 weeks” NCT04189367 ↗

Show 92 more sources

Known as Zinc acetate “In this study, the authors used zinc acetate to treat Japanese patients with Wilson disease and investigated its efficacy.” PMID 21078496 ↗ Sep 2010
7

NCT02868151 ↗

NCT07509918 ↗

NCT00696410 ↗

NCT00212368 ↗

NCT00004338 ↗

NCT03135522 ↗

NCT00373100 ↗

Known as Zinc Acetate Dihydrate ClinicalTrials.gov intervention name — accepted as the source's own label NCT06412653 ↗
Known as Zinc Chloride “0.454% Stannous Fluoride, 0.3% Zinc Chloride,1% Alumina toothpaste containing 1100 parts per million (ppm) fluoride.” NCT06602466 ↗
2

“Toothpaste containing 0.454% SnF2, 0.3% zinc chloride (ZnCl2) and 1% alumina.” NCT07169188 ↗

“15 ml 0,10% cymenol + 0,10% zinc chloride, one minute rinse” NCT05543603 ↗

Known as Zinc citrate “Compounded capsules containing each zinc citrate, green tea extract, and ascorbic acid.” NCT04898023 ↗
4

“Commercial Fluoridated toothpaste for gingivitis with zinc citrate.” NCT05463484 ↗

“Drug: Zinc citrate” NCT07140874 ↗

“0.5% zinc citrate” NCT07398378 ↗

NCT07405554 ↗

Known as Zinc Phosphate “A commercially available fluoride toothpaste containing 8% arginine + Zinc Phosphate” NCT07664592 ↗
Known as Zinc Sulfate, generic “Zinc Sulfate, generic” NCT01809132 ↗
Known as zinc sulphate “SM Fibro (Alpha lipoic acid 50mg, Beta-carotene 10mg, Elemental copper 1mg, Elemental selenium 75mcg, Lycopene 5mg, Vitamin E 10 IU, Zinc sulphate 27.45mg in form of the...” NCT02714543 ↗
15

“second group (n = 27) was on OHA and in addition 50 mg elemental zinc as zinc sulphate supplementation for 12 weeks” PMID 24082728 ↗ Jul 2013

“The 25 supplemented children had received an oral dose of 10 mg of zinc sulphate per day for 14 days” NCT04574544 ↗

“Zinc sulphate 125mg, day 2 to day 15” NCT01475227 ↗

“Drug: Zinc (zinc sulphate)” NCT00347386 ↗

“Zinc (zinc sulphate)” NCT07145268 ↗

“Zinc (zinc sulphate)” NCT00252304 ↗

“Drug: zinc sulphate” NCT06869798 ↗

“Zinc sulphate 50 mg” NCT05465434 ↗

NCT01210014 ↗

NCT00682955 ↗

Show 5 more sources

Known as Zn SO4 “Zinc Sulfate (Zn SO4) one tablet daily at bedtime which provides 50 mg elemental zinc (220 mg Zn SO4)” NCT01474486 ↗
Known as Zn sulfate “Neonates will receive oral Zn sulfate solution in either low doses (10 mg/day) or high doses (20 mg/day) given twice daily.” NCT06517862 ↗
Known as ZnCl2 “0.454 percent (%) Stannous Fluoride (SnF2), 0.3% Zinc Chloride (ZnCl2) and 1% Alumina” NCT06602466 ↗
1

“Toothpaste containing 0.454% SnF2, 0.3% zinc chloride (ZnCl2) and 1% alumina.” NCT07169188 ↗

Action Activate “MTT is an endogenous antioxidant that can be induced by both zinc (Zn) and ischemia.” PMID 28302075 ↗ Mar 2017
Modality Other / unclassified “micronutrients (especially of zinc and iron)” PMID 20730057 ↗ Aug 2010
Route Oral “They will be instructed to take 1 mL of the solution twice daily for two months.” NCT00104494 ↗