drugset / Trial / NCT03293641

Zinc Supplementation in Children With Sickle Cell Disease in Western Kenya

NCT03293641

RandomizedParallel-groupOpen-labelPrevention

Summary

Zinc is a nutritionally essential trace element found in previous studies to reduce growth retardation and improve immune function, which may also result in decreased incidence of infectious diseases including malaria, pneumonia and diarrhea. Sickle Cell Disease (SCD) patients are known to be susceptible to zinc deficiency and appear to benefit from zinc supplementation. The proposed pilot research project aims to investigate the influence of zinc supplementation on incidence of malaria infections, incidence of bacterial infections and investigate the influence of zinc supplementation on morbidity in children with SCD in western Kenya. The differences in incidence of morbidity and other secondary endpoints will be compared between the zinc group and the control group.

Timeline

Start
2016-05-20
Primary completion
2017-01-19
Completion
2017-01-19

Drugs

EvaluationDrugModalityDoseRoute
Subject Zinc Sulfate Unknown 10 mg
Background Hydroxyurea Other / unclassified
Background Penicillin V Small molecule
Background Proguanil Small molecule
Background folic acid Other / unclassified