Zinc With Chloroquine/Hydroxychloroquine in Treatment of COVID-19

NCT04447534 ↗

Phase 3 Completed 191 enrolled Tanta University

RandomizedParallel-groupDouble-blindTreatment

Summary

we want to investigate if zinc supplementation enhance the clinical efficacy of chloroquine in treatment of COVID-19.

Timeline

Start: 2020-06-23
Primary completion: 2020-07-15
Completion: 2020-08-15

Outcome

Missed primary endpoint

paper Clinical recovery after 28 days was achieved by 79.2% in the zinc group and 77.9% in zinc-free treatment group, without any significant difference (p = 0.969). PMID 33247380 ↗

paper The need for mechanical ventilation and the overall mortality rates did not show any significant difference between the 2 groups either (p = 0.537 and 0.986, respectively). PMID 33247380 ↗

Publications

Abd-Elsalam S, Soliman S, Esmail ES, Khalaf M, Mostafa EF, Medhat MA, Ahmed OA, El Ghafar MSA, Alboraie M, Hassany SM. Do Zinc Supplements Enhance the Clinical Efficacy of Hydroxychloroquine?: a Randomized, Multicenter Trial. Biol Trace Elem Res. 2021 Oct;199(10):3642-3646. doi: 10.1007/s12011-020-02512-1. Epub 2020 Nov 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Chloroquine	Small molecule	—	—
Subject	Hydroxychloroquine	Small molecule	—	—
Subject	Zinc Sulfate	Unknown	—	—