drugset / Trial / NCT04301336
Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell Anemia
Phase 2/3
Completed
350 enrolled
Beni-Suef University
Benisuef university hospital · collabMaternity and Children Hospital, Makkah · collabUniversity of Arizona · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
The aim of the present study is comparing the effectiveness of different treatment regimens for investigating the therapeutic potential for each one in management of Vaso-occlusive pain in pediatric sickle cell disease. In addition, investigators apply the Cost-effectiveness analysis (CEA) as a form of economic analysis that compares the relative costs and outcomes (effects) for different treatment regimens on vaso-occlusive painful crisis.
Timeline
- Start
- 2019-11-01
- Primary completion
- 2020-11-01
- Completion
- 2020-12-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Omega-3 fatty acids | Unknown | — | — |
| Subject | Simvastatin | Small molecule | — | Oral |
| Subject | Vit D | Unknown | — | Oral |
| Subject | Zinc Sulfate | Unknown | — | — |
| Background | Hydroxyurea | Other / unclassified | 20 mg/kg | — |
| Background | Morphine | Other / unclassified | 0.05 mg/kg | Intravenous |
| Background | folic acid | Other / unclassified | — | — |