Oral Contraceptive Pill Compared With Vitamin E in Women With Migraine

Phase 3 Unknown 360 enrolled Leiden University Medical Center Erasmus Medical Center · collab Netherlands Brain Foundation · collab ZonMw: The Netherlands Organisation for Health Research and Development · collab

RandomizedParallel-groupOpen-labelPrevention

Summary

Open-label randomized controlled trial to study the efficacy of continuous daily use of ethinylestradiol/levonorgestrel (30/150 µg/day) compared with vitamin E (400 IU/day) in the treatment of women with menstrually-related and perimenopausal migraine.

Timeline

Start: 2019-09-10
Primary completion: 2024-12
Completion: 2024-12

Publications

van der Arend BWH, van Casteren DS, Verhagen IE, MaassenVanDenBrink A, Terwindt GM. Continuous combined oral contraceptive use versus vitamin E in the treatment of menstrual migraine: rationale and protocol of a randomized controlled trial (WHAT!). Trials. 2024 Feb 15;25(1):123. doi: 10.1186/s13063-024-07955-8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Levonorgestrel	Small molecule	150 ug	Oral
Comparator	Vitamin E	Other / unclassified	400 iu	Oral
Subject	ethinyl estradiol	Small molecule	30 ug	Oral

Oral Contraceptive Pill Compared With Vitamin E in Women With Migraine

Summary

Timeline

Publications

Drugs

Indications