Drugs / Melatonin
Melatonin
also known as
N-acetyl-5-methoxytryptamine · Circadin · 5-methoxy-N-acetyltryptamine · BCI-049 · MELATL07959 · MLT · Nature Made · Dicoson · +20 more
Small molecule targets NLRP3 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | EU (EMA) | Circadin | — | 2007-06-29 | europa.eu ↗ |
Trials 256 · started per year
today
EU approved 2007
1
1
2
2
6
4
4
4
7
7
5
5
11
7
7
10
17
11
13
15
16
13
12
14
20
24
15
1
1995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 011 trials | ||||||
| Phase 0 | NCT06801379 | Jul → Dec 2025 overdue | insomnia | Woolcock Institute of Medical Research | Recruiting | No outcome recorded |
| Phase 0 | NCT03879707 | Jun 2025 → Jun 2028 | — | Stanford University | Withdrawn | No outcome recorded |
| Phase 0 | NCT06872944 | Mar → Jun 2025 | — | Cairo University | Completed | No outcome recorded |
| Phase 0 | NCT04233112 | May 2020 → Dec 2024 overdue | — | Duquesne University | Active not recruiting | No outcome recorded |
| Phase 0 | NCT02691897 | Jul 2019 → May 2020 | type 2 diabetes mellitus | Shiraz University of Medical Sciences | Unknown | No outcome recorded |
| Phase 0 | NCT03498131 | May 2018 → Jul 2022 | relapsing-remitting multiple sclerosis | Providence Health & Services | Completed | No outcome recorded |
| Phase 0 | NCT02963181 | Mar 2018 → May 2019 | autonomic nervous system disorder, hypertensive disorder, orthostatic hypotension | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Terminated | No outcome recorded |
| Phase 0 | NCT03885258 | May 2017 → Nov 2018 | pineal body neoplasm | University of Sao Paulo | Completed | No outcome recorded |
| Phase 0 | NCT02621944 | Nov 2016 → Mar 2027 expected | brain hypoxia - ischemia | University of Florida | Recruiting | No outcome recorded |
| Phase 0 | NCT02644590 | Feb → Sep 2016 | hypertensive disorder, type 1 diabetes mellitus | Sheba Medical Center | Unknown | No outcome recorded |
| Phase 0 | NCT04005222 | May 2014 → Sep 2016 | — | Beytepe Murat Erdi Eker State Hospital | Completed | No outcome recorded |
| Phase 117 trials | ||||||
| Phase 1 | NCT07003243 | May 2025 → May 2026 overdue | — | University of Baghdad | Not yet recruiting | No outcome recorded |
| Phase 1 | NCT05617833 | Apr 2024 → Sep 2027 expected | intracerebral hemorrhage | Johns Hopkins University | Recruiting | No outcome recorded |
| Phase 1 | NCT07549295 | Jan 2023 → Nov 2026 expected | fetal growth restriction | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | Enrolling by invitation | No outcome recorded |
| Phase 1 | NCT03995004 | Oct 2022 → Sep 2024 | — | The University of Hong Kong | Suspended | No outcome recorded |
| Phase 1 | NCT03519750 | Nov 2018 → Feb 2019 | — | Dennis Bregner Zetner | Completed | No outcome recorded |
| Phase 1 | NCT03514732 | Mar → Jul 2017 | sleep disorder | Sanofi | Completed | No outcome recorded |
| Phase 1 | NCT02691702 | Mar 2016 → Jan 2017 | — | Biogen | Completed | No outcome recorded |
| Phase 1 | NCT01904786 | Apr 2014 → Dec 2017 | brain hypoxia - ischemia | St. Louis University | Withdrawn | No outcome recorded Stop: Enrollment |
| Phase 1 | NCT02224937 | Dec 2013 → Feb 2014 | skin sensitivity to sun | Zealand University Hospital | Completed | No outcome recorded |
| Phase 1 | NCT01858155 | May 2013 → Dec 2017 | childhood malignant neoplasm | C17 Council | Completed | No outcome recorded |
| Phase 1 | NCT01724424 | Jun 2012 → May 2013 | infectious disease with sepsis | University of Aberdeen | Completed | No outcome recorded |
| Phase 1 | NCT01269671 | Jan 2011 → Jan 2012 | dyspepsia, irritable bowel syndrome | Medical College of Wisconsin | Withdrawn | No outcome recorded |
| Phase 1 | NCT00940550 | Jul → Aug 2009 | insomnia | University of Surrey | Completed | No outcome recorded |
| Phase 1 | NCT00927030 | Jan 2008 → Apr 2010 | autism spectrum disorder, insomnia | Vanderbilt University | Completed | No outcome recorded |
| Phase 1 | NCT00506259 | Jul 2007 → May 2018 | circadian rhythm sleep disorder, developmental disability, stereotypic movement disorder, syndrome caused by partial chromosomal deletion | National Human Genome Research Institute (NHGRI) | Completed | No outcome recorded |
| Phase 1 | NCT00506064 | Feb 2004 → Sep 2008 | breast cancer | M.D. Anderson Cancer Center | Terminated | No outcome recorded Stop: Enrollment |
| Phase 1 | NCT00282061 | — | circadian rhythm sleep disorder, delayed sleep phase type | Sheba Medical Center | Unknown | No outcome recorded |
| Phase 1/213 trials · 1 missed | ||||||
| Phase 1/2 | NCT06949904 | May → Dec 2025 overdue | pneumonia | Mian Muhammad Hassan Ahmed | Recruiting | No outcome recorded |
| Phase 1/2 | NCT04788979 | Apr → Dec 2021 | periodontitis | University of Baghdad | Unknown | No outcome recorded |
| Phase 1/2 | NCT05033639 | Mar → Dec 2021 | necrotizing enterocolitis | Ilocos Training and Regional Medical Center | Completed | No outcome recorded |
| Phase 1/2 | NCT03540485 | Nov 2019 → Feb 2026 | multiple sclerosis | Andalusian Public Foundation for Health Research in Seville | Terminated | No outcome recorded Stop: Enrollment |
| Phase 1/2 | NCT02319265 | Apr 2017 → Jun 2019 | infectious disease with sepsis | University of Aberdeen | Withdrawn | No outcome recorded |
| Phase 1/2 | NCT02845778 | May → Aug 2016 | — | Khon Kaen University | Unknown | No outcome recorded |
| Phase 1/2 | NCT03295162 | Nov 2015 → Mar 2017 | neonatal sepsis | Mohamed Hussein Metwally | Completed | No outcome recorded |
| Phase 1/2 | NCT02630004 | Nov 2015 → Dec 2017 | chemotherapy-induced oral mucositis | Spherium Biomed | Completed | No outcome recorded |
| Phase 1/2 | NCT02071160 | Jan 2012 → Dec 2013 | perinatal asphyxia | Tanta University | Completed | No outcome recorded |
| Phase 1/2 | NCT00867451 | Jan 2010 → Jun 2011 | attention deficit-hyperactivity disorder | Children's Hospital Medical Center, Cincinnati | Completed | No outcome recorded |
| Phase 1/2 | NCT00564590 | Oct 2008 → Jan 2011 | gastroesophageal reflux disease | Rabin Medical Center | Unknown | No outcome recorded |
| Phase 1/2 | NCT00288262 | Jun 2004 → Feb 2005 | — | Scripps Health | Terminated | No outcome recorded |
| Phase 1/2 | NCT00262470 | Apr 1997 → Dec 2029 expected | cardiac rhythm disease | Satish R. Raj | Active not recruiting | Missed primary |
| Phase 258 trials · 3 met primary · 3 missed | ||||||
| Phase 2 | NCT07221968 | Jul 2026 → Jul 2028 expected | developmental and epileptic encephalopathy, developmental and/or epileptic encephalopathy with spike-wave activation in sleep | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT07617922 | May 2026 → Apr 2027 expected | ureterolithiasis | Beni-Suef University | Recruiting | No outcome recorded |
| Phase 2 | NCT07375693 | Feb → Aug 2026 overdue | Parkinson disease | Bangladesh Medical University | Enrolling by invitation | No outcome recorded |
| Phase 2 | NCT07369284 | Feb 2026 → Jun 2027 expected | gestational diabetes | Obstetrics & Gynecology Hospital of Fudan University | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT07305350 | Dec 2025 → May 2026 overdue | brain hypoxia - ischemia | University of Child Health Sciences and Children's Hospital, Lahore | Active not recruiting | No outcome recorded |
| Phase 2 | NCT06252571 | Sep 2024 → Sep 2027 expected | idiopathic hypersomnia | University Hospital, Strasbourg, France | Recruiting | No outcome recorded |
| Phase 2 | NCT06226025 | Aug 2024 → Dec 2026 expected | bipolar disorder, circadian rhythm sleep disorder, delayed sleep phase type | Leslie Swanson | Recruiting | No outcome recorded |
| Phase 2 | NCT06404086 | Jul 2024 → Dec 2025 | hypersomnia, long COVID-19 | Duke University | Completed | No outcome recorded |
| Phase 2 | NCT06429059 | Jun 2024 → May 2025 | amyotrophic lateral sclerosis | Duke University | Completed | No outcome recorded |
| Phase 2 | NCT05740969 | Feb 2023 → Feb 2024 | actinic keratosis | Ismail Gögenur | Unknown | No outcome recorded |
| Phase 2 | NCT05713877 | Feb 2023 → Dec 2026 expected | delirium | Ciusss de L'Est de l'Île de Montréal | Recruiting | No outcome recorded |
| Phase 2 | NCT04932096 | Jan 2023 → Mar 2025 | traumatic brain injury | Oregon Health and Science University | Completed | No outcome recorded |
| Phase 2 | NCT05971485 | Aug 2022 → Sep 2024 | — | Ain Shams University | Completed | No outcome recorded |
| Phase 2 | NCT05593731 | Dec 2021 → Jul 2022 | — | Misr University for Science and Technology | Completed | No outcome recorded |
| Phase 2 | NCT05122130 | Nov 2021 → Sep 2022 | — | Salma Nabil | Unknown | No outcome recorded |
| Phase 2 | NCT04791943 | Nov 2021 → Oct 2025 | — | Montefiore Medical Center | Completed | No outcome recorded |
| Phase 2 | NCT05034809 | Oct 2021 → Aug 2022 | Dengue hemorrhagic fever | Ilocos Training and Regional Medical Center | Unknown | No outcome recorded |
| Phase 2 | NCT05042700 | Oct 2021 → Dec 2023 | — | Ismail Gögenur | Unknown | No outcome recorded |
| Phase 2 | NCT04784754 | Apr 2021 → Sep 2022 | COVID-19 | State University of New York at Buffalo | Withdrawn | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT04474483 | Nov 2020 → Jul 2022 | COVID-19 | State University of New York at Buffalo | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT04568863 | Jun → Nov 2020 | COVID-19 | Pharmamel S.L. | Completed | No outcome recorded |
| Phase 2 | NCT03848533 | Aug 2019 → Aug 2021 | prediabetes syndrome | University of Guadalajara | Unknown | No outcome recorded |
| Phase 2 | NCT03716583 | Apr 2019 → Jan 2021 | breast cancer, radiodermatitis | Dennis Bregner Zetner | Completed | No outcome recorded |
| Phase 2 | NCT03782740 | Mar 2019 → Jun 2021 | dysmenorrhea, endometriosis | Karolinska Institutet | Completed | Missed primary |
| Phase 2 | NCT03656484 | Jan → Dec 2019 | chronic periodontitis | Concordia Dent Srl | Completed | No outcome recorded |
| Phase 2 | NCT03894683 | Nov 2018 → May 2020 | symptomatic heart failure | Isfahan University of Medical Sciences | Unknown | No outcome recorded |
| Phase 2 | NCT03725267 | Oct 2018 → Jun 2021 | acute kidney injury | Hospital de Clinicas de Porto Alegre | Terminated | No outcome recorded |
| Phase 2 | NCT03597529 | Sep 2017 → Dec 2019 | migraine disorder | Amy Gelfand | Completed | No outcome recorded |
| Phase 2 | NCT03150797 | Aug 2017 → Dec 2019 | migraine disorder | Amy Gelfand | Terminated | No outcome recorded Stop: Business |
| Phase 2 | NCT02889432 | Jun 2016 → Aug 2017 | craniofacial and skeletal defects | The University of Hong Kong | Unknown | No outcome recorded |
| Phase 2 | NCT02631148 | Jan 2016 → Dec 2017 | obesity disorder, prediabetes syndrome | Brigham and Women's Hospital | Terminated | No outcome recorded |
| Phase 2 | NCT02506777 | Jul 2015 → Aug 2020 | breast cancer | N.N. Petrov National Medical Research Center of Oncology | Unknown | No outcome recorded |
| Phase 2 | NCT02506790 | Jul 2015 → Aug 2020 | breast cancer | N.N. Petrov National Medical Research Center of Oncology | Unknown | No outcome recorded |
| Phase 2 | NCT02487082 | Jun 2015 → Dec 2020 | autism spectrum disorder | Stony Brook University | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT02359448 | Apr → Sep 2015 | Parkinson disease | University College, London | Unknown | No outcome recorded |
| Phase 2 | NCT02099331 | Sep 2014 → Jul 2015 | atrial fibrillation | Johns Hopkins University | Withdrawn | No outcome recorded |
| Phase 2 | NCT01598259 | May 2014 → Jun 2016 | — | Shriners Hospitals for Children | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT02190838 | Apr 2014 → Dec 2015 | melanoma | N.N. Petrov National Medical Research Center of Oncology | Terminated | Missed primary |
| Phase 2 | NCT01628029 | Jan 2014 → Dec 2025 overdue | cancer, hematopoietic and lymphoid cell neoplasm, sleep disorder | M.D. Anderson Cancer Center | Active not recruiting | No outcome recorded |
| Phase 2 | NCT01965522 | Oct 2013 → Aug 2016 | female breast carcinoma | Juravinski Cancer Center | Completed | No outcome recorded |
| Phase 2 | NCT00640094 | May 2013 → Mar 2016 | acute myocardial infarction | Alberto Dominguez-Rodriguez | Terminated | No outcome recorded |
| Phase 2 | NCT01780883 | Feb → Jul 2013 | autism | Rennes University Hospital | Completed | No outcome recorded |
| Phase 2 | NCT01593774 | May 2012 → Mar 2013 | schizophrenia | Guilan University of Medical Sciences | Completed | Met primary |
| Phase 2 | NCT00965575 | Jun 2011 → Jun 2014 | epilepsy | Children's Hospital Medical Center, Cincinnati | Completed | No outcome recorded |
| Phase 2 | NCT00649961 | May 2010 → Feb 2011 | brain injury | Imperial College London | Completed | No outcome recorded |
| Phase 2 | NCT00940589 | Sep 2009 → Feb 2013 | Alzheimer disease, sleep disorder | Neurim Pharmaceuticals Ltd. | Completed | No outcome recorded |
| Phase 2 | NCT01038921 | Jul 2009 → Jun 2012 | metabolic syndrome X | Emory University | Completed | Met primary |
| Phase 2 | NCT00869869 | Mar 2009 → Mar 2010 | heart failure, sleep disorder | Brigham and Women's Hospital | Withdrawn | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT00731653 | Jul → Dec 2008 | major depressive disorder | Massachusetts General Hospital | Completed | No outcome recorded |
| Phase 2 | NCT00705003 | May → Dec 2008 | major depressive disorder | Massachusetts General Hospital | Completed | No outcome recorded |
| Phase 2 | NCT00544791 | Oct 2007 → Oct 2010 | cognitive disorder | Assaf-Harofeh Medical Center | Unknown | No outcome recorded |
| Phase 2 | NCT00972075 | Feb 2006 → Aug 2007 | blindness (disorder), non-24-hour sleep-wake syndrome | Neurim Pharmaceuticals Ltd. | Completed | No outcome recorded |
| Phase 2 | NCT00238108 | Oct 2005 → Aug 2010 | hypertensive disorder, sleep disorder | Brigham and Women's Hospital | Completed | No outcome recorded |
| Phase 2 | NCT00097474 | Dec 2004 → Jan 2006 | circadian rhythm sleep disorder, jet lag type | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Completed | No outcome recorded |
| Phase 2 | NCT00230737 | Oct 2004 → May 2008 | sleep disorder, initiating and maintaining sleep | Nalaka Gooneratne | Completed | No outcome recorded |
| Phase 2 | NCT00031967 | May 2002 → Mar 2004 | metastatic malignant neoplasm, radiation-induced disorder | Radiation Therapy Oncology Group | Completed | Missed primary |
| Phase 2 | NCT00816673 | Sep 1996 → May 1997 | insomnia | Neurim Pharmaceuticals Ltd. | Completed | No outcome recorded |
| Phase 2 | NCT00869128 | Nov 1995 → Mar 1997 | insomnia, type 2 diabetes mellitus | Neurim Pharmaceuticals Ltd. | Completed | Met primary |
| Phase 2/319 trials · 3 missed | ||||||
| Phase 2/3 | NCT06935292 | Apr 2025 → Apr 2026 overdue | — | Tanta University | Not yet recruiting | No outcome recorded |
| Phase 2/3 | NCT06809751 | Feb → May 2025 overdue | central serous chorioretinopathy | Mohsen Pourazizi | Not yet recruiting | No outcome recorded |
| Phase 2/3 | NCT07865988 | Oct 2024 → Aug 2026 | breast cancer | Menoufia University | Completed | No outcome recorded |
| Phase 2/3 | NCT06509191 | Sep 2024 → Mar 2025 overdue | delirium | Sultan Qaboos University | Recruiting | Missed primary |
| Phase 2/3 | NCT06062953 | Sep 2023 → Feb 2029 expected | insomnia, psychiatric disorder | Lone Baandrup | Recruiting | No outcome recorded |
| Phase 2/3 | NCT05474846 | Nov 2022 → Feb 2027 expected | anxiety, cancer, depressive disorder | M.D. Anderson Cancer Center | Active not recruiting | No outcome recorded |
| Phase 2/3 | NCT05536596 | Sep 2022 → Jun 2024 | autosomal dominant prognathism | Universitat Internacional de Catalunya | Unknown | No outcome recorded |
| Phase 2/3 | NCT05439876 | Jul 2022 → Jan 2025 | epilepsy | National Taiwan University Hospital | Completed | No outcome recorded |
| Phase 2/3 | NCT04287543 | May 2021 → Jul 2022 | Parkinson disease | Mexican Social Security Institute | Withdrawn | No outcome recorded |
| Phase 2/3 | NCT04353128 | Apr → Oct 2020 | COVID-19 | Instituto de Investigación Hospital Universitario La Paz | Completed | No outcome recorded |
| Phase 2/3 | NCT03524937 | Feb 2019 → May 2021 | — | Assistance Publique - Hôpitaux de Paris | Completed | Missed primary |
| Phase 2/3 | NCT02798367 | Mar 2018 → Oct 2021 | insomnia | Ache Laboratorios Farmaceuticos S.A. | Unknown | No outcome recorded |
| Phase 2/3 | NCT04122599 | Jul 2017 → Nov 2019 | delirium | University Hospital Tuebingen | Unknown | No outcome recorded |
| Phase 2/3 | NCT02993588 | Dec 2016 → Aug 2017 | ovarian dysfunction | Assiut University | Unknown | No outcome recorded |
| Phase 2/3 | NCT02757066 | Jun 2016 → Sep 2018 | autism spectrum disorder, sleep disorder | Nobelpharma | Completed | No outcome recorded |
| Phase 2/3 | NCT02041455 | Jun 2010 → Jan 2014 | fibromyalgia | Hospital de Clinicas de Porto Alegre | Unknown | No outcome recorded |
| Phase 2/3 | NCT00925899 | Oct 2009 → Mar 2013 | cancer | Bispebjerg Hospital | Completed | Missed primary |
| Phase 2/3 | NCT00315926 | Jan 2007 → Jul 2008 | aortic aneurysm | University Hospital, Gentofte, Copenhagen | Completed | No outcome recorded |
| Phase 2/3 | NCT00113906 | Mar 2005 → Aug 2006 | sleep disorder | University Hospital, Gentofte, Copenhagen | Completed | No outcome recorded |
| Phase 341 trials · 2 met primary · 4 missed | ||||||
| Phase 3 | NCT07418554 | Jan 2027 → May 2029 expected | post-traumatic stress disorder, sleep disorder | University Hospital, Strasbourg, France | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07576764 | Sep 2026 → Jan 2029 expected | anorexia nervosa, sleep disorder | Assistance Publique Hopitaux De Marseille | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07652801 | Jul → Dec 2026 expected | brain hypoxia - ischemia | University of Child Health Sciences and Children's Hospital, Lahore | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07336277 | Jun → Jul 2026 overdue | sleep disorder | Emory University | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07503600 | Mar → Aug 2026 overdue | gram-negative bacterial infections | Ain Shams University | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT06859957 | Apr 2025 → Dec 2026 expected | — | Bart Koes | Active not recruiting | No outcome recorded |
| Phase 3 | NCT06846086 | Feb 2025 → Jan 2026 overdue | cardiomyopathy | Tanta University | Recruiting | No outcome recorded |
| Phase 3 | NCT05541276 | Jan 2025 → Dec 2026 expected | delirium | Rigshospitalet, Denmark | Recruiting | No outcome recorded |
| Phase 3 | NCT06476392 | Dec 2024 → Mar 2026 | insomnia | Odense University Hospital | Completed | No outcome recorded |
| Phase 3 | NCT06405204 | Jun → Dec 2024 | — | Beni-Suef University | Unknown | Met primary |
| Phase 3 | NCT06685679 | May → Dec 2024 | pulmonary arterial hypertension | Ain Shams University | Completed | No outcome recorded |
| Phase 3 | NCT06103188 | Oct 2023 | anxiety | University of Jordan | Completed | Missed primary |
| Phase 3 | NCT05084196 | Jun 2023 → Jun 2027 expected | acute kidney injury | Rutgers, The State University of New Jersey | Recruiting | No outcome recorded |
| Phase 3 | NCT05502900 | Oct 2022 → Jan 2031 expected | medium/large size posterior uveal melanoma | Gustav Stalhammar | Recruiting | No outcome recorded |
| Phase 3 | NCT04335968 | Jan 2021 → Apr 2025 | — | Assistance Publique - Hôpitaux de Paris | Completed | No outcome recorded |
| Phase 3 | NCT04233502 | Sep 2020 → Sep 2022 | autism spectrum disorder | Neurim Pharmaceuticals Ltd. | Withdrawn | No outcome recorded |
| Phase 3 | NCT04424875 | Jul 2020 → Mar 2021 | impacted teeth, multiple | Fayoum University | Completed | No outcome recorded |
| Phase 3 | NCT04193501 | Feb 2020 → Feb 2021 | irritable bowel syndrome | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Unknown | No outcome recorded |
| Phase 3 | NCT04229719 | Nov 2019 → Jun 2020 | periodontal disorder | University of Baghdad | Unknown | No outcome recorded |
| Phase 3 | NCT03764020 | Jun → Nov 2019 | hypertensive disorder | Tehran University of Medical Sciences | Unknown | No outcome recorded |
| Phase 3 | NCT03715465 | Feb 2019 → Nov 2021 | circadian rhythm sleep disorder, delayed sleep phase type | University of Michigan | Completed | Missed primary |
| Phase 3 | NCT02333149 | Jan 2019 → Nov 2021 | attention deficit-hyperactivity disorder, insomnia | University of Alberta | Withdrawn | No outcome recorded |
| Phase 3 | NCT03708341 | Nov 2018 → Mar 2024 | psychotic disorder | Saint-Joseph University | Unknown | No outcome recorded |
| Phase 3 | NCT03557229 | Jul 2018 → Jun 2022 | disorder of defective peroxisome oxidative status, infectious disease with sepsis | American British Cowdray Medical Center | Unknown | No outcome recorded |
| Phase 3 | NCT04034771 | Jan → Apr 2018 | traumatic brain injury | Cairo University | Completed | No outcome recorded |
| Phase 3 | NCT03062839 | Sep 2017 → Feb 2019 | attention deficit-hyperactivity disorder | Hospital Israelita Albert Einstein | Unknown | No outcome recorded |
| Phase 3 | NCT04137627 | Jul 2017 → Jul 2018 | oral cavity squamous cell carcinoma | Indonesia University | Completed | No outcome recorded |
| Phase 3 | NCT02681887 | Sep 2016 → Jun 2021 | obesity disorder, prediabetes syndrome | Brigham and Women's Hospital | Unknown | No outcome recorded |
| Phase 3 | NCT02654314 | Jul 2016 → Nov 2017 | delirium | Yale University | Terminated | No outcome recorded |
| Phase 3 | NCT02454855 | Jul 2015 → May 2021 | cancer | Centre Jean Perrin | Terminated | Missed primary |
| Phase 3 | NCT02374567 | Jan 2015 → Jun 2017 | anxiety disorder, dementia, depressive disorder, schizophrenia +1 | Hannover Medical School | Terminated | No outcome recorded |
| Phase 3 | NCT01860716 | May → Dec 2013 | — | Aragon Institute of Health Sciences | Unknown | No outcome recorded |
| Phase 3 | NCT01858909 | May → Dec 2013 | infectious disease with sepsis | Aragon Institute of Health Sciences | Unknown | No outcome recorded |
| Phase 3 | NCT01705639 | Nov 2012 → Aug 2014 | diabetes mellitus, glucose intolerance | University of Helsinki | Completed | No outcome recorded |
| Phase 3 | NCT01566474 | Apr 2012 → Jun 2017 | Barrett esophagus | Aragon Institute of Health Sciences | Completed | No outcome recorded |
| Phase 3 | NCT01357031 | May 2010 → Dec 2011 | migraine disorder | Hospital Israelita Albert Einstein | Completed | No outcome recorded |
| Phase 3 | NCT00397189 | Oct 2006 → Dec 2008 | insomnia | Neurim Pharmaceuticals Ltd. | Completed | Met primary |
| Phase 3 | NCT00513357 | Jun 2006 → Dec 2012 | digestive system cancer, lung cancer | M.D. Anderson Cancer Center | Completed | Missed primary |
| Phase 3 | NCT00404456 | Apr 2005 → Jul 2007 | sleep disorder | Meander Medical Center | Completed | No outcome recorded |
| Phase 3 | NCT00261183 | Dec 2004 → Dec 2006 | — | Tel-Aviv Sourasky Medical Center | Unknown | No outcome recorded |
| Phase 3 | NCT00000171 | — | Alzheimer disease, sleep disorder | National Institute on Aging (NIA) | Completed | No outcome recorded |
| Phase 430 trials | ||||||
| Phase 4 | NCT07691996 | Sep 2026 → Jun 2027 expected | — | Rutgers, The State University of New Jersey | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07605767 | Nov 2025 → Jan 2026 | periodontitis | Liaquat College of Medicine and Dentistry | Completed | No outcome recorded |
| Phase 4 | NCT07316582 | Nov 2025 → Jun 2026 overdue | chronic periodontitis | Al-Azhar University | Enrolling by invitation | No outcome recorded |
| Phase 4 | NCT07162272 | Jun → Aug 2025 | — | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT06821425 | Jan → Aug 2025 | periodontal disorder | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT07034560 | Nov 2024 → Nov 2025 overdue | hyperpigmentation of the skin | Thammasat University | Active not recruiting | No outcome recorded |
| Phase 4 | NCT07550751 | Aug 2024 → Apr 2025 | — | Aswan University Hospital | Completed | No outcome recorded |
| Phase 4 | NCT06380491 | Jun 2023 → Dec 2027 expected | obstructive sleep apnea syndrome | National Institute of Medical Sciences and Nutrition Salvador Zubiran | Recruiting | No outcome recorded |
| Phase 4 | NCT05247125 | Mar 2022 → Jan 2026 overdue | circadian rhythm sleep disorder, ischemic stroke | Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health | Recruiting | No outcome recorded |
| Phase 4 | NCT03438526 | Jan 2022 → Dec 2027 expected | delirium | University Hospital, Basel, Switzerland | Recruiting | No outcome recorded |
| Phase 4 | NCT04318067 | Sep 2020 → Apr 2024 | attention deficit-hyperactivity disorder, sleep disorder | Allan Hvolby | Unknown | No outcome recorded |
| Phase 4 | NCT04400266 | Aug 2020 → Jul 2028 expected | depressive disorder, traumatic brain injury | Massachusetts General Hospital | Recruiting | No outcome recorded |
| Phase 4 | NCT03689998 | Sep 2019 → Jan 2021 | — | Cairo University | Completed | No outcome recorded |
| Phase 4 | NCT03966235 | Jun 2019 → Jun 2021 | coronary artery disorder | Chinese PLA General Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT04304807 | Dec 2018 → Dec 2019 | necrotizing enterocolitis, pulmonary immaturity | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT03692026 | Oct 2018 → Feb 2020 | — | Cairo University | Unknown | No outcome recorded |
| Phase 4 | NCT03590197 | Aug 2018 → Mar 2020 | generalized epilepsy | All India Institute of Medical Sciences, Bhubaneswar | Completed | No outcome recorded |
| Phase 4 | NCT03368430 | Jul 2016 → Jun 2017 | periodontal disorder | Mansoura University | Completed | No outcome recorded |
| Phase 4 | NCT02282241 | Feb 2016 → Sep 2021 | delirium | University of British Columbia | Withdrawn | No outcome recorded |
| Phase 4 | NCT03258294 | Jan 2016 → Dec 2018 | Parkinson disease | KIMJisun | Unknown | No outcome recorded |
| Phase 4 | NCT02836743 | Jan 2016 → Dec 2017 | REM sleep behavior disorder | Seoul National University Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT02768077 | Jan 2016 → Feb 2017 | Parkinson disease | Kuhnil Pharmaceutical Co., Ltd. | Unknown | No outcome recorded |
| Phase 4 | NCT03831165 | Sep 2015 → Sep 2021 | genital herpes | University of Sao Paulo General Hospital | Completed | No outcome recorded |
| Phase 4 | NCT03121521 | Sep 2012 → Sep 2016 | liver disorder | Medical University of Lodz | Completed | No outcome recorded |
| Phase 4 | NCT02265822 | Sep 2012 → Oct 2013 | — | Azienda Ospedaliera Universitaria Policlinico "G. Martino" | Completed | No outcome recorded |
| Phase 4 | NCT01695070 | Sep 2012 → Oct 2014 | fetal growth restriction | Monash University | Completed | No outcome recorded |
| Phase 4 | NCT01431092 | Oct 2011 → Jun 2014 | bipolar disorder, schizoaffective disorder, schizophrenia | Lone Baandrup | Completed | No outcome recorded |
| Phase 4 | NCT01393574 | Jun 2011 → Jun 2012 | attention deficit-hyperactivity disorder, insomnia | Assaf-Harofeh Medical Center | Unknown | No outcome recorded |
| Phase 4 | NCT01087359 | Jun 2010 → Jan 2011 | — | Herlev Hospital | Completed | No outcome recorded |
| Phase 4 | NCT01811160 | Oct 2008 → Nov 2011 | — | National Institute of Psychiatry Ramón de la Fuente Muñiz | Completed | No outcome recorded |
| Phase not applicable67 trials | ||||||
| — | NCT07334197 | Dec 2026 → Dec 2029 expected | peripartum cardiomyopathy | Tanta University | Not yet recruiting | No outcome recorded |
| — | NCT07695246 | Aug 2026 → Aug 2029 expected | insomnia | The University of Hong Kong | Not yet recruiting | No outcome recorded |
| — | NCT07553143 | May → Dec 2026 expected | gallbladder disorder | Armed Forces Medical Institute Bangladesh | Recruiting | No outcome recorded |
| — | NCT07349459 | Apr → Aug 2026 | doxorubicin induced cardiomyopathy, female breast carcinoma | Tanta University | Completed | No outcome recorded |
| — | NCT07495605 | Mar 2026 → Dec 2027 expected | — | Cairo University | Not yet recruiting | No outcome recorded |
| — | NCT07344467 | Jan 2026 → Jun 2027 expected | anxiety | Tanta University | Recruiting | No outcome recorded |
| — | NCT07869030 | Nov 2025 → Jun 2027 expected | bone remodeling disease, periodontal disorder | Future University in Egypt | Recruiting | No outcome recorded |
| — | NCT07610876 | Aug 2025 → Oct 2026 expected | — | Suez Canal University | Recruiting | No outcome recorded |
| — | NCT07345715 | Jul 2025 → Jul 2027 expected | adenoid hypertrophy | Tanta University | Recruiting | No outcome recorded |
| — | NCT07825961 | Apr 2025 → Jul 2026 | diabetic kidney disease | Tanta University | Completed | No outcome recorded |
| — | NCT07062757 | Mar 2025 → Mar 2027 expected | craniofacial and skeletal defects | Bezmialem Vakif University | Enrolling by invitation | No outcome recorded |
| — | NCT07307677 | Mar 2025 → Mar 2026 overdue | polycystic ovary syndrome | Mst.Sumyara Khatun | Recruiting | No outcome recorded |
| — | NCT06808425 | Feb 2025 → Feb 2034 expected | attention deficit-hyperactivity disorder, sleep disorder | Halmstad University | Recruiting | No outcome recorded |
| — | NCT06768580 | Jan 2025 → Oct 2026 expected | delirium | Tanta University | Recruiting | No outcome recorded |
| — | NCT06756828 | Jan 2025 → Aug 2026 overdue | Alzheimer disease | Saint Vincent's Hospital, Korea | Not yet recruiting | No outcome recorded |
| — | NCT06838104 | Dec 2024 → Jun 2025 overdue | schizophrenia | Lahore General Hospital | Active not recruiting | No outcome recorded |
| — | NCT06606899 | Sep → Dec 2024 | — | Ain Shams University | Completed | No outcome recorded |
| — | NCT06421454 | Sep 2024 → Jun 2025 | decubitus ulcer | Fundacion Rioja Salud | Unknown | No outcome recorded |
| — | NCT07735806 | Jul 2024 → Aug 2026 | impacted teeth, multiple | Kafrelsheikh University | Completed | No outcome recorded |
| — | NCT06237556 | Feb → Dec 2024 | anxiety, coronary artery disorder, sleep disorder | Ain Shams University | Unknown | No outcome recorded |
| — | NCT07568873 | Jan → Dec 2024 | — | Zagazig University | Completed | No outcome recorded |
| — | NCT06997263 | Jan 2024 → Jan 2025 | anxiety | Benha University | Completed | No outcome recorded |
| — | NCT06533033 | Jan → Jul 2024 overdue | lichen planus, oral | Hams Hamed Abdelrahman | Active not recruiting | No outcome recorded |
| — | NCT06076668 | Oct 2023 → Oct 2024 | delirium | Tanta University | Unknown | No outcome recorded |
| — | NCT06372561 | May 2023 → Sep 2024 overdue | dental caries, dental pulp disorder | Suez Canal University | Recruiting | No outcome recorded |
| — | NCT06191523 | Apr → Oct 2023 | neonatal sepsis | Universitas Sebelas Maret | Completed | No outcome recorded |
| — | NCT05699876 | Jan → Nov 2023 | anxiety | All India Institute of Medical Sciences | Unknown | No outcome recorded |
| — | NCT07829393 | Jan 2023 → Jul 2026 | alveolar periostitis, chronic apical periodontitis | Mansoura University | Completed | No outcome recorded |
| — | NCT07090720 | Jan 2023 → Jan 2025 | pulmonary hypertension, neonatal | Tanta University | Completed | No outcome recorded |
| — | NCT04878198 | Dec 2022 → Jun 2023 | autism spectrum disorder, sleep disorder | Education University of Hong Kong | Completed | No outcome recorded |
| — | NCT05440734 | Jun 2022 → Dec 2024 | insomnia | Douglas Mental Health University Institute | Terminated | No outcome recorded Stop: Business |
| — | NCT06868745 | May 2022 → Jul 2023 | circadian rhythm sleep disorder, open-angle glaucoma | University of Sao Paulo | Completed | No outcome recorded |
| — | NCT07343947 | Jan 2022 → Dec 2023 | infertility disorder | University of Sao Paulo General Hospital | Completed | No outcome recorded |
| — | NCT05285124 | Jul 2021 → Dec 2022 | cognitive disorder | First Affiliated Hospital of Zhejiang University | Unknown | No outcome recorded |
| — | NCT06724432 | Jun 2021 → Jun 2023 | — | University of Parma | Completed | No outcome recorded |
| — | NCT05492812 | Jan → Dec 2021 | — | Suleyman Demirel University | Completed | No outcome recorded |
| — | NCT05976451 | Oct 2020 → Apr 2022 | gingival recession | Ain Shams University | Completed | No outcome recorded |
| — | NCT06816277 | Sep 2020 → Jul 2023 | periodontitis | Universidad Complutense de Madrid | Completed | No outcome recorded |
| — | NCT04665453 | Sep 2020 → Sep 2022 | epilepsy | University Medical Centre Ljubljana | Completed | No outcome recorded |
| — | NCT04570254 | Aug → Dec 2020 | COVID-19, acute respiratory distress syndrome, viral pneumonia | Unidad Temporal COVID-19 en Centro Citibanamex | Completed | No outcome recorded |
| — | NCT05236907 | Jul → Oct 2020 | delirium | University of Baghdad | Completed | No outcome recorded |
| — | NCT04409522 | May → Jun 2020 | COVID-19 | Mohammad Sadegh Bagheri Baghdasht | Unknown | No outcome recorded |
| — | NCT05596617 | Apr 2020 → May 2021 | COVID-19 | Hospital San Carlos, Madrid | Completed | No outcome recorded |
| — | NCT04187807 | Oct 2019 → Mar 2020 | delirium | Autonomous University of San Luis Potosí | Unknown | No outcome recorded |
| — | NCT03826563 | Jan 2019 → Apr 2023 | psychotic disorder | Children's Hospital of Philadelphia | Completed | No outcome recorded |
| — | NCT03788733 | Dec 2018 → Jun 2019 | circadian rhythm sleep disorder | Universidad de Murcia | Unknown | No outcome recorded |
| — | NCT03303378 | Nov 2017 → Nov 2019 | myocardial stunning | Chinese PLA General Hospital | Unknown | No outcome recorded |
| — | NCT03966950 | Jun 2017 → Nov 2019 | benign prostatic hyperplasia, cognitive disorder | University of Sao Paulo | Unknown | No outcome recorded |
| — | NCT03117725 | May 2017 → Aug 2019 | female infertility | Bundang CHA Hospital | Unknown | No outcome recorded |
| — | NCT02642640 | Nov 2016 → Mar 2022 | circadian rhythm sleep disorder, glucose metabolism disease | Brigham and Women's Hospital | Completed | No outcome recorded |
| — | NCT04392063 | Jun 2016 → Jun 2018 | cerebral palsy | Ain Shams University | Completed | No outcome recorded |
| — | NCT02663570 | Jun 2015 → Jan 2016 | polycystic ovary syndrome | Catholic University of the Sacred Heart | Unknown | No outcome recorded |
| — | NCT03784495 | Jan → Dec 2014 | muscular atrophy | Azienda di Servizi alla Persona di Pavia | Completed | No outcome recorded |
| — | NCT02463318 | Sep 2012 → Jun 2015 | multiple sclerosis | Tehran University of Medical Sciences | Completed | No outcome recorded |
| — | NCT01505465 | Feb 2012 → Jun 2013 | delirium | Hospital for Special Surgery, New York | Completed | No outcome recorded |
| — | NCT03563287 | Jan 2012 → Dec 2014 | morbid obesity | University of Eastern Finland | Completed | No outcome recorded |
| — | NCT04352062 | Jan 2011 → Oct 2018 | — | Medical University of Lodz | Completed | No outcome recorded |
| — | NCT00795236 | Nov 2009 → Jun 2015 | blindness (disorder), sleep disorder | Oregon Health and Science University | Terminated | No outcome recorded |
| — | NCT00950885 | Sep 2009 → Aug 2013 | circadian rhythm sleep disorder, delayed sleep phase type, circadian rhythm sleep disorder, jet lag type, circadian rhythm sleep disorder, shift work type | Brigham and Women's Hospital | Completed | No outcome recorded |
| — | NCT01391390 | Sep 2008 → Apr 2011 | tardive dyskinesia | Beijing HuiLongGuan Hospital | Completed | No outcome recorded |
| — | NCT00625742 | Feb 2008 → Jun 2014 | cancer of unknown primary site, hypoproteinemia, hypercatabolic | M.D. Anderson Cancer Center | Terminated | No outcome recorded Stop: Enrollment |
| — | NCT00512070 | Jul 2007 → Dec 2010 | bipolar disorder, metabolic syndrome X, obesity disorder, schizoaffective disorder +1 | Seattle Institute for Biomedical and Clinical Research | Completed | No outcome recorded |
| — | NCT00387179 | Oct 2006 → Mar 2010 | circadian rhythm sleep disorder | National Heart, Lung, and Blood Institute (NHLBI) | Unknown | No outcome recorded |
| — | NCT00688935 | Jan 2005 → May 2015 | blindness (disorder) | Oregon Health and Science University | Terminated | No outcome recorded |
| — | NCT00692094 | Aug 2004 → May 2008 | blindness (disorder) | Oregon Health and Science University | Terminated | No outcome recorded |
| — | NCT00691444 | Sep 2002 → Dec 2015 | blindness (disorder) | Oregon Health and Science University | Terminated | No outcome recorded |
| — | NCT00911053 | Jun 1997 → Jun 2012 | blindness (disorder), insomnia, sleep-wake disorder | Oregon Health and Science University | Terminated | No outcome recorded |
| Comparator or background therapy115 trials | ||||||
| Phase 0 | NCT06802913 Comparator | Jul → Dec 2025 overdue | insomnia | Woolcock Institute of Medical Research | Recruiting | No outcome recorded |
| Phase 0 | NCT05829148 Comparator | May 2023 → Nov 2024 | — | Egymedicalpedia | Unknown | No outcome recorded |
| Phase 0 | NCT04959825 Comparator | Jul 2021 → Apr 2022 | — | Cairo University | Completed | No outcome recorded |
| Phase 0 | NCT03688464 Comparator | Feb 2019 | atopic eczema | University of Nebraska | Withdrawn | No outcome recorded |
| Phase 0 | NCT01805089 Comparator | Oct 2006 → Jul 2009 | breast cancer | Dana-Farber Cancer Institute | Completed | No outcome recorded |
| Show all 115 trials opens the full record — a long page | ||||||
News releases announcing trial results or a regulatory action · 3
| Date | Issuer | Release |
|---|---|---|
| 2025-10-21 | Neurim Pharmaceuticals Ltd. | Regulatory Slenyto is approved in Canada neurim.com ↗
We are pleased to announce that Health Canada has granted marketing authorization for Slenyto®- Extended-Release Melatonin Formulation – as a Prescription Drug for Insomnia in Children with Autism Spectrum disorder and Smith Magenis Syndrome. |
| 2025-03-31 | Neurim Pharmaceuticals Ltd. | Regulatory European Marketing Authorization for Pediatric Slenyto® for the treatment of insomnia in children with Attention Deficit Hyperactivity Disorder (ADHD). neurim.com ↗
We are pleased to share that Neurim Pharmaceuticals has received European Marketing Authorization for Pediatric Prolonged-Release Melatonin (Slenyto®) for the treatment of insomnia in children with Attention Deficit Hyperactivity Disorder (ADHD). |
| 2024-07-30 | Neurim Pharmaceuticals Ltd. | Regulatory Positive CHMP opinion on Slenyto® for the treatment of Insomnia in children with Neurogenetic Disorders (NGDs) neurim.com ↗
We are excited to announce that Neurim Pharmaceuticals received a positive CHMP opinion on Slenyto ® (Pediatric Prolonged-Release Melatonin) for the treatment of Insomnia in children with Neurogenetic Disorders (NGDs). |
All press releases naming this drug 25 releases
Evidence & citations 33 cited values
Every value below carries the sentence it was read from. 376 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Melatonin | “Two equally loaded capsules containing:
Melatonin (2.0 mg) Nicotine (1.0 mg) Bupropion (37.5 mg) Repaglinide (0.25 mg) Losartan (12.5 mg) Omeprazole (10 mg) Chlorzoxazone...” NCT03563287 ↗364“This is a randomised, double-blind, 3-way crossover, single dose, placebo-controlled study investigating the effect on night time awakening body sway of melatonin and zolpidem...” NCT01280734 ↗ “Open Label, Single Ascending Dose, Cross-over Study to Assess the Pharmacokinetics of Circadin® (Prolonged-Release Melatonin) Mini Tablets in Children With Neurodevelopmental...” NCT01903681 ↗ “To-date, melatonin (N-acetyl-5-methoxytryptamine) is a well-investigated, endogenous indoleamine which is primarily secreted from the pineal gland and responsible for...” NCT03368430 ↗ “Melatonin (N-acetyl-5-methoxy-tryptamine) is an indoleamine synthesized and secreted by the pineal gland and other organs, such as the retina, bone marrow, and intestines in a...” NCT04229719 ↗ “Melatonin, a hormone and a popular natural health product, is commonly provided to children by parents and recommended by healthcare providers, but high quality pediatric...” PMID 27473269 ↗ Jul 2016 “The purpose of this study is to verify the efficacy of NPC-15 (melatonin 1 mg/d or 4 mg/d) versus placebo to sleep latency with electronic sleep diaries.” NCT02757066 ↗ “The treatment group received two pills in the morning containing Vit C Vit D zinc and minerals and one pill of 2 mg of melatonin in the evening” NCT05670444 ↗ “Preclinical data show that melatonin (MLT) and erythropoietin (EPO), when administered in a sustained dosing regimen, may promote neuro-repair” NCT05617833 ↗ “The investigational medication is an oral solution containing two active ingredients: delta-9 tetrahydrocannabinol (THC) and melatonin.” NCT05543681 ↗ “melatonin 10 mg per os in the preoperative night and the immediate postoperative night and the first and second postoperative nights.” NCT03966950 ↗ |
| Known as | 5-methoxy-N-acetyltryptamine | “Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal gland and locally in the retina following a circadian rhythm, with low levels during the...” PMID 26514204 ↗ Oct 20152“Melatonin (5-methoxy-N-acetyltryptamine) is an endogenous lipid-soluble hormone produced primarily by the pineal gland in humans.” NCT05651347 ↗ “Melatonin ( 5-Methoxy-N-Acetyltryptamine) at dose 1mg/morning and 3mg/at bedtime (period 6 months)” NCT04352062 ↗ |
| Known as | BCI-049 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00731653 ↗ |
| Known as | Circadin | “Melatonin supplementation is achieved by the administration of (Circadin) at a dose of 2 mg / day according to its MA form of prolonged-release tablet of 2 mg.” NCT02454855 ↗13“Melatonin(Circadin®) is taken orally, once daily before going to sleep for a period of 4 weeks.” NCT02768077 ↗ “Melatonin(Circadin®) is taken orally, once daily before going to sleep for a period of 4 weeks.” NCT03258294 ↗ “Circadin, controlled release melatonin tablet 2mg by mouth each day before bedtime for 12 weeks” NCT02681887 ↗ “Circadin® is a newly developed slow release galenic formulation of melatonin” NCT00816673 ↗ “melatonin (Circadin ®) 0.2 mg/kg” NCT06489327 ↗ “Drug: Melatonin (Circadin ®)” NCT03438526 ↗ “Melatonin ("Circadin")” NCT01741389 ↗ “melatonin (Circadin)” NCT07034560 ↗ |
| Known as | Dicoson | “Melatonin (Dicoson, Dicofarm, Italy, 5 drops = 1 mg) was administered orally.” NCT06724432 ↗ |
| Known as | FR MLT | “Fast Release Melatonin (FR MLT)” NCT01161108 ↗ |
| Known as | MEL | “Of the 31 patients, 16 randomly received add-on melatonin (MEL), whereas 15 received add-on placebo.” PMID 15145300 ↗ Jun 2004 |
| Known as | MELATL07959 | “MELATONIN (MELATL07959)” NCT07375693 ↗1“MELATONIN (MELATL07959)” NCT03514732 ↗ |
| Known as | Melatonin 1 mg tablet Thiopharma | “Melatonin 1 mg tablet Thiopharma” NCT02107079 ↗ |
| Known as | Melatonin 2,5 mg capsule (compounded by UMCU Pharnacy) | “Melatonin 2,5 mg capsule (compounded by UMCU Pharnacy)” NCT02107079 ↗ |
| Known as | Melatonin Brand: General Nutrition Center | “Melatonin Brand: General Nutrition Center” NCT02536417 ↗ |
| Known as | Melatonin Lek-AM 10mg | “Melatonin Lek-AM 10mg” NCT03121521 ↗ |
| Known as | Melatonin powder | “Melatonin powder” NCT04229719 ↗ |
| Known as | Melatonine | “Melatonine in the form of syrup will be given orally to child.” NCT04665453 ↗ |
| Known as | Meloset | “Premedication with 3 mg melatonin (Meloset) tablet orally 1-2 hour prior to anesthesia” NCT01486615 ↗ |
| Known as | MLT | “Preclinical data show that melatonin (MLT) and erythropoietin (EPO), when administered in a sustained dosing regimen, may promote neuro-repair” NCT05617833 ↗1“bright light therapy (BLT), melatonin (MLT), methylphenidate (MP) and eight combinations” PMID 31924662 ↗ Jan 2020 |
| Known as | N-acetyl-5-methoxytryptamine | “Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone secreted by the pineal gland with several important functions, including regulation of the circadian rhythms,...” NCT05971485 ↗24“Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that is endogenously produced and secreted by the pineal gland in the brain following a circadian rhythm, with a...” NCT03995004 ↗ “To-date, melatonin (N-acetyl-5-methoxytryptamine) is a well-investigated, endogenous indoleamine which is primarily secreted from the pineal gland and responsible for...” NCT03368430 ↗ “Furthermore, Melatonin (N-acetyl-5-methoxy tryptamine) is a substance secreted by multiple organs including the pineal gland, retina, bone marrow, the gastro-intestinal tract...” NCT03692026 ↗ “Melatonin, also known as N-acetyl-5-methoxytryptamine which has a a) immunomodulator; b) free radical scavenger; c) prevention of oxidative stress and d) anti-inflammatory7-10.” NCT05033639 ↗ “Melatonin (N-acetyl-5-methoxytryptamine) is an endogenous indolamine hormone produced by the pineal gland, best known for regulating circadian rhythm and the sleep-wake cycle.” NCT07553143 ↗ “Melatonin (N-acetyl-5-methoxytryptamine) exhibits antioxidant, anti-inflammatory, antimicrobial, and osteogenic properties that may enhance peri-implant bone regeneration.” NCT07829393 ↗ “Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that is endogenously produced and secreted by the pineal gland in the brain in a circadian rhythm” NCT02889432 ↗ “Melatonin (N-acetyl-5-methoxytryptamine) is an antioxidant molecule that has demonstrated beneficial effects on bone metabolism and osseointegration.” NCT07610876 ↗ “Melatonin (N-acetyl-5-methoxytryptamine) is a naturally-occurring hormone in the human body and offers antiemetic, analgesic, and anxiolytic effects” NCT07096635 ↗ “Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that is discharged by the pineal gland produced from the amino acid tryptophan.” NCT06768580 ↗ |
| Known as | N-acetylmethoxytryptamine | “Melatonin, or N-acetylmethoxytryptamine, is a hormone secreted by the pineal gland in the brain.” NCT06872944 ↗ |
| Known as | Natrol | “Participants in this intervention group will undergo a 10-week melatonin supplement intervention period, where melatonin supplement (Natrol®, Chatsworth CA) will be provided 30...” NCT04878198 ↗ |
| Known as | Natrol brand liquid melatonin | “Natrol brand liquid melatonin” NCT00927030 ↗ |
| Known as | Nature Made | “Three days before the operation patients will receive 5 mg of melatonin (Melatonin, Nature Made, Canada, and USA) one hour before assigned sleep time until the time of...” NCT06237556 ↗1“oral melatonin tablets (NatureMade brand)” NCT03826563 ↗ |
| Known as | NPC-15 | “The purpose of this study is to verify the efficacy of NPC-15 (melatonin 1 mg/d or 4 mg/d) versus placebo to sleep latency with electronic sleep diaries.” NCT02757066 ↗ |
| Known as | OBM | “oral bedtime melatonin (OBM)” NCT05596617 ↗ |
| Known as | PedPRM | “Pediatric prolonged-release melatonin (PedPRM, Slenyto®) is the only melatonin formulation approved by the European Medicines Agency (EMA) for chronic insomnia in children aged...” NCT07576764 ↗ |
| Known as | PRM | “The authors recently reported on efficacy and safety of prolonged-release melatonin formulation (PRM; Circadin 2 mg) in elderly insomnia patients.” PMID 21091391 ↗ Nov 2010 |
| Known as | Sleep Tight TM by Nature's Harmony Melatonin | “Sleep Tight TM by Nature's Harmony® Melatonin” NCT01161108 ↗ |
| Known as | Slenyto | “Pediatric prolonged-release melatonin (PedPRM, Slenyto®) is the only melatonin formulation approved by the European Medicines Agency (EMA) for chronic insomnia in children aged...” NCT07576764 ↗ |
| Known as | TDM, melatonin sleep patch from Respro Labs (7 mg/8hr). | “TDM, melatonin sleep patch from Respro Labs ™ (7 mg/8hr).” NCT02747628 ↗ |
| Known as | TR MLT | “Timed Release Melatonin (TR MLT)” NCT01161108 ↗ |
| Action | Inhibit | “Thus, if melatonin suppressed this pulse generator in postmenopausal women, it might moderate hot flashes.” NCT00288262 ↗ |
| Modality | Small molecule | “Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine compound.” NCT01114373 ↗ |
| Route | Oral | “oral administration” NCT00000171 ↗ |
| Target | NLRP3 | “Melatonin, on the other hand, is a hormone in the body that can inhibit Inflammation NLRP3” NCT04409522 ↗ |