drugset / Trial / NCT06421454
Clinical Trial for the Evaluation of Melatonin in the Treatment of Pressure Ulcers
Unknown
50 enrolled
Fundacion Rioja Salud
Instituto de Salud Carlos III · collabPharmamel S.L. · collabUniversidad de Granada · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
Melatonin has been shown to prevent cellular damage produced by oxidative stress or in situations of ischaemia, inhibiting the synthesis of oxidants and pro inflammatory factors such as pro-inflammatory cytokines, substances which are present in pressure ulcers and can affect the healing process, slowing it down. Melatonin gel has also been shown to prevent ulcers in the oral mucosa due to radiotherapy. Therefore, the hypothesis for this study is that the melatonin cream provides greater ulcer area reduction than standard pressure ulcer treatment.
Timeline
- Start
- 2024-09-01
- Primary completion
- 2025-06-01
- Completion
- 2025-11-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Melatonin | Small molecule | — | Topical |