drugset / Trial / NCT02506790
Neoadjuvant Toremifene With Melatonin or Metformin in Locally Advanced Breast Cancer
RandomizedParallel-groupOpen-labelTreatment
Summary
This study evaluates the addition melatonin and metformin to toremifene in the treatment of locally advanced breast cancer. Third of patients will receive toremifene, other third will receive combination of melatonin and toremifene and other patients will receive combination of metformin and toremifene.
Timeline
- Start
- 2015-07
- Primary completion
- 2020-08
- Completion
- 2022-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Melatonin | Small molecule | 3 mg | — |
| Subject | Metformin | Small molecule | 850 mg | — |
| Background | Toremifene | Small molecule | 60 mg | — |