HD-tDCS Combined With Circadian Rhythm Reconstruction and Micro Expression Changes on Consciousness Recovery in Patients With Chronic Disturbance of Consciousness

Summary

The circadian rhythm characteristics of sleep cycle and neuroendocrine in patients with chronic disorder of consciousness show different degrees of disorder, and the relationship between this disorder and consciousness level is unclear.The researchers used HD-tDCS to treat patients with chronic disturbance of consciousness who intervened in circadian rhythm, and used a variety of methods such as EEG, fMRI, protein metabolism, ERP and micro-expression to explore the mechanism of improving the state of consciousness of HD-DCS and the relationship between circadian rhythm and patients' consciousness level

Timeline

Start

2021-07-01

Primary completion

2022-12-31

Completion

2024-12

Publications

• Wen X, Yu J, Zhu G, Wang J, Sun Y, Zhou J, Cai J, Meng F, Ling Y, Sun Y, Zhao J, He F, Cheng Q, Xu C, Gao J, Li J, Luo B. Efficacy of melatonin for prolonged disorders of consciousness: a double-blind, randomized clinical trial. BMC Med. 2024 Dec 3;22(1):576. doi: 10.1186/s12916-024-03793-2.

Drugs

Indications