drugset / Trial / NCT06724432
Analgesic and Antioxidant Effects of Melatonin in Pediatric Surgery
Completed
44 enrolled
University of Parma
University of Florida · collabUniversity of Messina · collabUniversity of Siena · collabUniversity of Urbino "Carlo Bo" · collab
RandomizedParallel-groupDouble-blindDiagnostic
Summary
Background. Long-term consequences of postoperative pain are detrimental in children. We tested the hypothesis that melatonin reduces postoperative pain and oxidative stress involving sirtuin pathway in children undergoing surgery. Methods. Thirty-one children were randomly assigned to oral supplementation with melatonin or placebo, before surgery. Plasma levels of 4-hydroxynonenal (4-HNE), melatonin, sirtuin 1 (SIRT1), and circulating miR-34 and miR-124a were analyzed at T0 (pre-hospitalization), T1 (before surgery), and T2 (1 h after the end of the surgery).
Timeline
- Start
- 2021-06-01
- Primary completion
- 2023-06-01
- Completion
- 2024-09-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Melatonin | Small molecule | 0.5 mg/kg | Oral |
Indications
No indication recorded.