Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia

Summary

This is a double blinded, randomised, crossover study with 12 healthy men between 18 and 40 year. The design is based on 6 days: * day 1: On day time administration of LPS. * day 2: On night time administration of LPS. * day 3: On day time administration of LPS + Placebo. * day 4: On day time administration of LPS + melatonin. * day 5: On night time administration of LPS + placebo. * day 6: On night time administration og LPS + melatonin. Measuring the inflammatoric and oxidative response of LPS and the effect of melatonin compared to placebo on the endotoxaemia.

Timeline

Start

2010-06

Primary completion

2011-01

Completion

2011-02

Drugs

Indications

No indication recorded.