drugset / Trial / NCT00238108
Melatonin Supplements for Improving Sleep in Individuals With Hypertension
Phase 2
Completed
16 enrolled
Brigham and Women's Hospital
National Center for Complementary and Integrative Health (NCCIH) · collabOffice of Dietary Supplements (ODS) · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
This study will evaluate the effectiveness of treatment with melatonin supplements in improving sleep in individuals with high blood pressure who are taking beta-blockers.
Timeline
- Start
- 2005-10
- Primary completion
- 2010-08
- Completion
- 2010-08
Publications
- Background Scheer FA, Van Montfrans GA, van Someren EJ, Mairuhu G, Buijs RM. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension. 2004 Feb;43(2):192-7. doi: 10.1161/01.HYP.0000113293.15186.3b. Epub 2004 Jan 19.
- Scheer FA, Morris CJ, Garcia JI, Smales C, Kelly EE, Marks J, Malhotra A, Shea SA. Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. Sleep. 2012 Oct 1;35(10):1395-402. doi: 10.5665/sleep.2122.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Melatonin | Small molecule | 2.5 mg | Oral |