Mucolytic Solution Before Upper Endoscopy

Summary

Study was designed to evaluate efficacy of mucolytic solution ingested before upper endoscopy on visibility of gastric mucosa.

Timeline

Start

2016-11

Primary completion

2017-03

Completion

2017-05

Outcome

Missed primary endpoint

paper The visibility score was similar in all arms - 17.4 ± 1.9 vs. 17.0 ± 2.0 vs. 17.6 ± 1.8 (P=0.32). PMID 34158672 ↗

paper Administration of the mucolytic solution in our study did not increase the mucosal visibility score in the esophagus, stomach and duodenum. PMID 34158672 ↗

Publications

• Stepan M, Falt P, Pipek B, Fojtik P, Hanousek M, Hill M, Urban O. Administration of mucolytic solution before upper endoscopy - double-blind, monocentric, randomized study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023 Mar;167(1):69-73. doi: 10.5507/bp.2021.038. Epub 2021 Jun 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	N-acetylcysteine	Small molecule	400 mg	—
Subject	Simethicone	Other / unclassified	100 mg	—

Indications