Ablation vs Amiodarone for Treatment of AFib in Patients With CHF and an ICD

Phase 4 Completed 203 enrolled Texas Cardiac Arrhythmia Research Foundation Casa Sollievo della Sofferenza IRCCS · collab Catholic University, Italy · collab Southlake Health · collab Stanford University · collab Sutter Health · collab The University of Texas Medical Branch, Galveston · collab University of Foggia · collab University of Kansas · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

1. To determine if catheter-based atrial fibrillation (AF) ablation is superior to Amiodarone treatment for symptomatic persistent/permanent AF in ICD/CRTD patients with an impaired left ventricular function. 2. Hypothesis: AF ablation is better than Amiodarone for subjects with symptomatic persistent or permanent AF and impaired LV function in terms of recurrence of AF, quality of life, 6-minute walk distance, EF and total number of hospitalizations.

Timeline

Start: 2008-10
Primary completion: 2014-12
Completion: 2015-12

Publications

Di Biase L, Mohanty P, Mohanty S, Santangeli P, Trivedi C, Lakkireddy D, Reddy M, Jais P, Themistoclakis S, Dello Russo A, Casella M, Pelargonio G, Narducci ML, Schweikert R, Neuzil P, Sanchez J, Horton R, Beheiry S, Hongo R, Hao S, Rossillo A, Forleo G, Tondo C, Burkhardt JD, Haissaguerre M, Natale A. Ablation Versus Amiodarone for Treatment of Persistent Atrial Fibrillation in Patients With Congestive Heart Failure and an Implanted Device: Results From the AATAC Multicenter Randomized Trial. Circulation. 2016 Apr 26;133(17):1637-44. doi: 10.1161/CIRCULATIONAHA.115.019406. Epub 2016 Mar 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Amiodarone	Small molecule	—	Oral

Ablation vs Amiodarone for Treatment of AFib in Patients With CHF and an ICD

Summary

Timeline

Publications

Drugs

Indications