drugset / Trial / NCT02132767
Rate Control Versus Rhythm Control For Postoperative Atrial Fibrillation
Phase 3
Completed
523 enrolled
Icahn School of Medicine at Mount Sinai
Canadian Institutes of Health Research (CIHR) · collabNational Heart, Lung, and Blood Institute (NHLBI) · collabNational Institute of Neurological Disorders and Stroke (NINDS) · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to compare the therapeutic strategies of rate control versus rhythm control in cardiac surgery patients who develop in-hospital postoperative atrial fibrillation or atrial flutter (AF). In patients who develop AF during hospitalization after cardiac surgery, the hypothesis is that a strategy of rhythm control will reduce days in hospital within 60 days of the occurrence of AF compared to a strategy of rate control.
Timeline
- Start
- 2014-05
- Primary completion
- 2015-09
- Completion
- 2015-09
Publications
- Afifi A. CTS trials network: Rate control vs rhythm control for atrial fibrillation after cardiac surgery - Do bitter pills have blessed effects? Glob Cardiol Sci Pract. 2016 Jun 30;2016(2):e201615. doi: 10.21542/gcsp.2016.15.
- Gillinov AM, Bagiella E, Moskowitz AJ, Raiten JM, Groh MA, Bowdish ME, Ailawadi G, Kirkwood KA, Perrault LP, Parides MK, Smith RL 2nd, Kern JA, Dussault G, Hackmann AE, Jeffries NO, Miller MA, Taddei-Peters WC, Rose EA, Weisel RD, Williams DL, Mangusan RF, Argenziano M, Moquete EG, O'Sullivan KL, Pellerin M, Shah KJ, Gammie JS, Mayer ML, Voisine P, Gelijns AC, O'Gara PT, Mack MJ; CTSN. Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery. N Engl J Med. 2016 May 19;374(20):1911-21. doi: 10.1056/NEJMoa1602002. Epub 2016 Apr 4.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amiodarone | Small molecule | 0.5 mg | Oral |
| Comparator | Amiodarone | Small molecule | 200 mg | Oral |
| Comparator | Atorvastatin | Small molecule | — | — |
| Comparator | Digoxin | Other / unclassified | — | — |
| Comparator | Propranolol | Small molecule | — | — |