drugset / Trial / NCT03905759
Prophylaxis Against Postoperative Atrial Fibrillation in Patients Undergoing On-pump CABG
RandomizedParallel-groupSingle-blindPrevention
Summary
Atrial fibrillation in the postoperative period of myocardial revascularization surgery (AF-POMR) occurs in 10% to 65% of patients, increasing morbidity and mortality after surgery. is associated with an increase in hospital length of stay, and, thus, in costs,and can cause serious clinical complications, such as hypotension, heart failure, stroke and other thromboembolic disorders.Although not completely understood, the electrophysiological mechanism of AF-POMR is believed to be reentry.
Timeline
- Start
- 2019-04-03
- Primary completion
- 2020-04-10
- Completion
- 2020-04-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amiodarone | Small molecule | 200 mg | — |
| Comparator | Colchicine | Small molecule | 0.5 mg | Oral |
| Comparator | Dronedarone | Small molecule | 200 mg | — |