drugset / Trial / NCT05492968
The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic Performance
RandomizedParallel-groupTriple-blindPrevention
Summary
The use of catecholamines for blood pressure and hemodynamic management is essential during undergoing surgery. The type of the catecholamine with the most clinical meaningful effect is still unknown. Therefore, the investigators evaluate the effect of intraoperative continuous infusion of epinephrine, norepinephrine and phenylephrine on intraoperative cardiac output. The investigators further evaluate the effect of epinephrine, norepinephrine and phenylephrine on regional brain and regional tissue oxygenation during surgery.
Timeline
- Start
- 2022-09-01
- Primary completion
- 2024-08-01
- Completion
- 2024-08-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Epinephrine | Other / unclassified | 0.02 mg/ml | — |
| Comparator | Norepinephrine | Other / unclassified | 0.02 mg/ml | — |
| Comparator | Phenylephrine | Small molecule | 0.2 mg/ml | — |