Tranexamic Acid Versus Adrenaline for Controlling Iatrogenic Endobronchial Bleeding

Summary

Endobronchial bleeding is a relatively common complication of diagnostic bronchoscopy. Both tranexamic acid and adrenaline are used topically for the control of endobronchial bleeding. The aim of this study is to compare the efficacy of tranexamic acid with adrenaline in controlling iatrogenic endobronchial bleeding after diagnostic bronchoscopy.

Timeline

Start

2021-02-22

Primary completion

2022-02-04

Completion

2022-02-04

Outcome

Missed primary endpoint

paper Bleeding was stopped in 83.1% of patients (54/65) in both groups (P = 1). PMID 36273651 ↗

paper We found no significant difference between adrenaline and TXA for controlling noncatastrophic iatrogenic endobronchial bleeding PMID 36273651 ↗

Publications

• Badovinac S, Glodic G, Sabol I, Dzubur F, Makek MJ, Baricevic D, Korsic M, Popovic F, Srdic D, Samarzija M. Tranexamic Acid vs Adrenaline for Controlling Iatrogenic Bleeding During Flexible Bronchoscopy: A Double-Blind Randomized Controlled Trial. Chest. 2023 Apr;163(4):985-993. doi: 10.1016/j.chest.2022.10.013. Epub 2022 Oct 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Epinephrine	Other / unclassified	0.2 mg	Other
Subject	Tranexamic Acid	Small molecule	100 mg	Other

Indications