drugset / Trial / NCT04630886
Use of Tranexamic Acid in Reduction of Post-Op Complications in Mohs Micrographic Surgery
RandomizedParallel-groupSingle-blindSupportive care
Summary
The purpose of this study is to evaluate the use of locally injected tranexamic acid (TXA) under the skin during Mohs micrographic surgery for removal of skin cancers in patients on anticoagulation. TXA may be helpful in reducing bleeding and pain during surgery, and may also lead to fewer post-operative complications following surgery such as graft loss, specifically in patients on blood-thinners.
Timeline
- Start
- 2021-06-16
- Primary completion
- 2024-01-16
- Completion
- 2024-01-16
Publications
- Background Zilinsky I, Barazani TB, Visentin D, Ahuja K, Martinowitz U, Haik J. Subcutaneous Injection of Tranexamic Acid to Reduce Bleeding During Dermatologic Surgery: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Dermatol Surg. 2019 Jun;45(6):759-767. doi: 10.1097/DSS.0000000000001786.
- Background Poeran J, Rasul R, Suzuki S, Danninger T, Mazumdar M, Opperer M, Boettner F, Memtsoudis SG. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety. BMJ. 2014 Aug 12;349:g4829. doi: 10.1136/bmj.g4829.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Tranexamic Acid | Small molecule | 50 mg/ml | Subcutaneous |
| Background | Epinephrine | Other / unclassified | — | Subcutaneous |
| Background | Lidocaine | Other / unclassified | 1 % | Subcutaneous |