A Study of the Effect of Epinephrine on Platelet Reactivity in Subjects Treated With Ticagrelor
Summary
The study is an experimental observational study in ten healthy volunteers. Based on an in vitro study, it is hypothesize that a low dose epinephrine infusion will improve platelet function in healthy volunteers who have received ticagrelor. Volunteers fulfilling all of the inclusion and none of the exclusion criteria will be included. Enrollment will be continued until the required sample size is achieved (10 subjects). Once informed consent is obtained, screening data will be collected to determine each subject's eligibility for study participation. The total expected duration of subject participation is 18 days, from screening visit to end of follow-up. The active participation is 8h (study procedure 4 hours, observation period 4 hours).
Timeline
- Start
- 2018-02-28
- Primary completion
- 2018-03-28
- Completion
- 2018-03-28
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Epinephrine | Other / unclassified | 0.01 ug/kg | Intravenous |
| Subject | Epinephrine | Other / unclassified | 0.05 ug/kg | Intravenous |
| Subject | Epinephrine | Other / unclassified | 0.1 ug/kg | Intravenous |
| Subject | Epinephrine | Other / unclassified | 0.15 ug/kg | Intravenous |
| Subject | Metoprolol | Other / unclassified | 5 mg | Intravenous |
| Background | Ticagrelor | Small molecule | 180 mg | Oral |
Indications
No indication recorded.