POHCA Resuscitation: Evaluation of IM Epinephrine

Summary

This is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster quasi randomized control trial (SW-CRCT) looking to evaluate early intramuscular (IM) epinephrine in the management of pediatric out-of-hospital cardiac arrest (POHCA).

Timeline

Start

2024-01-08

Primary completion

2028-01

Completion

2029-01

Publications

• Idrees S, Assaf M, Davis M, Garcia-Bournissen F, Loosley J, Miller MR, Tijssen JA. Evaluating intramuscular epinephrine in pediatric out-of-hospital cardiac arrest (the PRIME trial): study protocol for a multi-centre, stepped-wedge cluster quasi-randomized controlled trial. Trials. 2026 Jun 8. doi: 10.1186/s13063-026-09776-3. Online ahead of print.

Drugs

Indications