Role of Adrenaline in in the Inflammatory Response in Diabetes

Summary

The primary aim of the present study is to study the effect of adrenaline administration on inflammatory parameters (e.g. leukocyte phenotype, cytokines, inflammatory proteins). Secondary objectives consist of the effect of adrenaline on atherogenic parameters. * All participants will receive intravenous infusion of adrenaline for an hour * We will draw blood at 7 time points, not including screening * Participants will be asked to return for a total of 4 times Researchers will compare 2 groups, healthy individuals versus people with diabetes type 1 to see if the inflammatory reaction to adrenaline differs between these two groups.

Timeline

Start

2023-12-03

Primary completion

2024-09-03

Completion

2024-09-03

Publications

• Mustafajev IF, Hendriksz MS, Stienstra R, Tack CJ, de Galan BE, Meijer RI. Adrenaline is a prominent driver of inflammatory responses following hypoglycaemia. Diabetologia. 2026 Jun;69(6):1675-1685. doi: 10.1007/s00125-026-06667-9. Epub 2026 Jan 29.

Drugs

Indications