RCT of Gastric ESD With or Without Epineprhine Added Solution

Summary

This is an international multi-center randomised controlled study comparing outcomes of gastric endoscopic submucosal dissection (ESD) with or without addition of epinephrine in the submucosal injection solution.

Timeline

Start

2020-01-10

Primary completion

2022-12-31

Completion

2023-01-31

Publications

• Yip HC, Uedo N, Iwagami H, Waki K, Ohtsu K, Miyaoka M, Yao K, Akamatsu T, Konishi T, Nakano S, Nakanishi H, Doyama H, Machida H, Jung K, Chiu P, Iwasaki T, Uchita K, Kawamura T, Takizawa K, Kitamura Y, Li JW, Ang TL, Shimokawa T, Zhu Z, Yung MY. The use of diluted epinephrine during gastric endoscopic submucosal dissection: an international randomized controlled trial. Gastrointest Endosc. 2026 Jan 29:S0016-5107(26)00072-6. doi: 10.1016/j.gie.2026.01.031. Online ahead of print.

Drugs

Indications