Combining Lidocaine and Ropivacaine for an Infraclavicular Brachial Plexus Nerve Block

Phase 3 Completed 78 enrolled Nordsjaellands Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The aim of the study is to investigate how the combination of ropivacaine (a slow onset, long duration local anesthetic) with lidocaine (a rapid onset, shorter duration local anesthetic) affects the onset and duration of a lateral infraclavicular plexus brachialis (LIC) block in patients undergoing non-acute hand surgery.

Timeline

Start: 2024-04-18
Primary completion: 2024-10-24
Completion: 2024-11-23

Outcome

Met primary endpoint

paper Compared with that in the R150 group, the mean duration of analgesia was reduced by 311 min (95% confidence interval [CI], 212 to 411; P < 0.001) PMID 40859881 ↗

Publications

Yousef S, Steensbaek MT, Bahuet AR, Knudsen RL, Harwood CD, Rosenstock CV, Andersen MF, Rothe C, Lange KHW, Norskov AK, Lundstrom LH. The effect of combining lidocaine and ropivacaine on the duration and onset time of an ultrasound-guided infraclavicular brachial plexus nerve block: A randomised controlled trial. Eur J Anaesthesiol. 2025 Dec 1;42(12):1046-1055. doi: 10.1097/EJA.0000000000002261. Epub 2025 Sep 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Epinephrine	Other / unclassified	5 ug/ml	—
Subject	Lidocaine	Other / unclassified	200 mg	—
Subject	Ropivacaine	Other / unclassified	100 mg	—
Subject	Ropivacaine	Other / unclassified	150 mg	—

Indications

No indication recorded.