Caudal Versus Intravenous Dexmedetomidine for Supplementation of Caudal Analgesia in Children

Summary

The purpose of this study is to compare the effects of caudal dexmedetomidine with intravenous dexmedetomidine on caudal levobupivacaine analgesia in children undergoing lower abdominal surgeries.

Timeline

Start

2012-10

Primary completion

2014-01

Completion

2014-01

Outcome

Met primary endpoint

paper median duration of analgesia in the L-Dcau group was 14.2 hour compared to 6 hour in the L group with a median difference of 8.5 hour PMID 30302881 ↗

paper with a median difference of 8.5 hour [95% CI (6.5, 10.5), P <0.001]. PMID 30302881 ↗

paper The median duration of analgesia in the L-Div group was 12.4 hour compared to 6 hour in the L group with a median difference of 6.4 hour [95% CI (4, 8.5), P <0.001]. PMID 30302881 ↗

Publications

• Yao Y, Yu C, Zhang X, Guo Y, Zheng X. Caudal and intravenous dexmedetomidine similarly prolong the duration of caudal analgesia in children: A randomized controlled trial. Paediatr Anaesth. 2018 Oct;28(10):888-896. doi: 10.1111/pan.13469.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	1 ug/kg	Other
Background	Levobupivacaine	Other / unclassified	0.25 %	Other
Background	Sevoflurane	Other / unclassified	—	—

Indications