drugset / Trial / NCT01736020
Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy
Phase 1
Unknown
293 enrolled
Southern California Institute for Research and Education
National Institute of Mental Health (NIMH) · collabUniversity of California, Irvine · collab
Non-randomizedParallel-groupSingle-blindBasic science
Summary
This preclinical phase 1 development study in healthy volunteers seeks to identify if low doses of commonly used non-triggering anesthetic agents might have clinical utility for modulating emotional memory processing and to understand the nature of the brain mechanisms of drug action. Optimally, a drug, dose and brain mechanism of action will be identified that will form the foundation for future use in clinical studies of patients with PTSD.
Timeline
- Start
- 2009-09
- Primary completion
- 2017-04
- Completion
- 2017-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | — | Intravenous |
| Subject | Ketamine | Small molecule | — | Intravenous |
| Subject | Nitrous Oxide | Other / unclassified | — | Inhaled |
| Subject | Propofol | Small molecule | — | Intravenous |
Indications
No indication recorded.