Dexmedetomidine vs. Midazolam Sedation for Endobronchial Ultrasound

Phase 2/3 Completed 197 enrolled Post Graduate Institute of Medical Education and Research, Chandigarh

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The randomized controlled trial will compare efficacy and safety of dexmedetomidine to midazolam for sedation during endobronchial ultrasound

Timeline

Start: 2016-03
Primary completion: 2017-02-01
Completion: 2017-02-01

Outcome

Met primary endpoint

paper Rescue midazolam requirement was significantly lesser in 99 Group D (0.9 ± 1.2 boluses) than in 98 Group M (2.0 ± 2.4 boluses), subjects. PMID 33849367 ↗

Publications

Kumari R, Jain K, Agarwal R, Dhooria S, Sehgal IS, Aggarwal AN. Fixed dexmedetomidine infusion versus fixed-dose midazolam bolus as primary sedative for maintaining intra-procedural sedation during endobronchial ultrasound-guided transbronchial needle aspiration: a double blind randomized controlled trial. Expert Rev Respir Med. 2021 Dec;15(12):1597-1604. doi: 10.1080/17476348.2021.1918000. Epub 2021 Apr 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	0.6 ug/kg	Intravenous
Subject	Midazolam	Small molecule	0.5 mg	Intravenous
Subject	Midazolam	Small molecule	2 mg	Intravenous
Background	Fentanyl	Other / unclassified	1 ug/kg	Intravenous

Indications

No indication recorded.