drugset / Trial / NCT04144933
Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
RandomizedParallel-groupTriple-blindPrevention
Summary
The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel function in patients undergoing elective, laparoscopic, colorectal surgery compared to traditional opioid-containing general anesthetic techniques. It is hypothesized that this intraoperative OFA regimen will reduce postoperative opioid consumption, and expedite return of bowel function in this population.
Timeline
- Start
- 2021-05-15
- Primary completion
- 2024-07-30
- Completion
- 2024-08-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 0.5 ug/kg | — |
| Subject | Dexmedetomidine | Other / unclassified | — | — |
| Subject | Ketamine | Small molecule | 0.15 mg/kg | — |
| Subject | Ketamine | Small molecule | — | — |
| Comparator | Lidocaine | Other / unclassified | 0.5 mg/kg | — |
| Comparator | Lidocaine | Other / unclassified | 1.5 mg/kg | — |
| Comparator | Lidocaine | Other / unclassified | — | — |
| Subject | Magnesium Sulfate | Other / unclassified | 30 mg/kg | — |
| Comparator | Sufentanil | Other / unclassified | — | — |
| Comparator | Acetaminophen | Small molecule | 975 mg | — |
| Background | Dexamethasone | Small molecule | 6 mg | — |
| Comparator | Gabapentin | Unknown | 300 mg | — |
| Background | Ondansetron | Other / unclassified | 4 mg | — |
| Comparator | Sevoflurane | Other / unclassified | — | — |