drugset / Trial / NCT00991627
Different Approaches to Maternal Hypotension During Cesarean Section
Phase 4
Completed
36 enrolled
University of Parma
Azienda Ospedaliero-Universitaria di Parma · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
The aim of this study is to compare two different therapeutic approaches to blood pressure reduction: pharmacological vs. non-pharmacological. The setting is that of patients undergoing scheduled Cesarean section under spinal anesthesia and suffering from aorta-caval compression syndrome, which causes a sudden drop in blood pressure.
Timeline
- Start
- 2009-09
- Primary completion
- 2010-08
- Completion
- 2010-08
Publications
- Background Kinsella SM, Lohmann G. Supine hypotensive syndrome. Obstet Gynecol. 1994 May;83(5 Pt 1):774-88.
- Background Cyna AM, Andrew M, Emmett RS, Middleton P, Simmons SW. Techniques for preventing hypotension during spinal anaesthesia for caesarean section. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD002251. doi: 10.1002/14651858.CD002251.pub2.
- Background Kinsella SM, Norris MC. Advance prediction of hypotension at cesarean delivery under spinal anesthesia. Int J Obstet Anesth. 1996 Jan;5(1):3-7. doi: 10.1016/s0959-289x(96)80067-7.
- Background Helwig JT, Parer JT, Kilpatrick SJ, Laros RK Jr. Umbilical cord blood acid-base state: what is normal? Am J Obstet Gynecol. 1996 Jun;174(6):1807-12; discussion 1812-4. doi: 10.1016/s0002-9378(96)70214-4.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Ephedrine | Small molecule | 37.5 mg | Intravenous |
| Background | Atropine | Other / unclassified | 0.1 mg/kg | Intravenous |
| Background | Bupivacaine | Other / unclassified | 10 mg | Intrathecal |
| Background | Ephedrine | Small molecule | 6.25 mg | Intravenous |
| Background | Lactated Ringer's solution | Unknown | 25 ml | Intravenous |
| Background | Morphine | Other / unclassified | 200 ug | Intrathecal |