Comparison of Phenylephrine and Ephedrine in the Treatment of Hemodynamic Disorders After Spinal Anesthesia in the Elderly

Completed 50 enrolled Medical University of Warsaw

RandomizedParallel-groupSingle-blindPrevention

Summary

Spinal anesthesia is often used for lower limb surgery in elderly. Hypotension is a side effect of spinal block. In this study, intravenous ephedrine and phenylephrine will be compared with each other to prevent spinal anesthesia-induced hypotension, which is defined in absolute terms as a systolic blood pressure \< 100 mmHg or in relative terms as a 20% fall of systolic blood pressure from baseline.

Timeline

Start: 2019-02-01
Primary completion: 2019-02-24
Completion: 2023-02-01

Publications

Background Abbasivash R, Sane S, Golmohammadi M, Shokuhi S, Toosi FD. Comparing prophylactic effect of phenylephrine and ephedrine on hypotension during spinal anesthesia for hip fracture surgery. Adv Biomed Res. 2016 Oct 26;5:167. doi: 10.4103/2277-9175.190943. eCollection 2016.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ephedrine	Small molecule	25 mg	Intravenous
Comparator	Phenylephrine	Small molecule	0.3 mg	Intravenous

Indications

No indication recorded.