drugset / Trial / NCT06257316
Appropriate Dosage of Vasopressor in Neonates and Infants
RandomizedSequentialQuadruple-blindTreatment
Summary
In this study, the investigators will evaluate cerebral blood flow before and after drug infusion using ultrasound to suggest blood pressure criteria and dosage of ephedrine, a vasopressor, to maintain adequate cerebral blood flow in neonates and infants undergoing surgery and anesthesia.
Timeline
- Start
- 2024-02-15
- Primary completion
- 2027-02-28
- Completion
- 2028-02-28
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ephedrine | Small molecule | 0.1 mg/kg | Intravenous |
| Comparator | Ephedrine | Small molecule | 0.2 mg/kg | Intravenous |
| Comparator | Ephedrine | Small molecule | 0.3 mg/kg | Intravenous |
| Comparator | Ephedrine | Small molecule | 0.5 mg/kg | Intravenous |
| Comparator | Ephedrine | Small molecule | 1 mg/kg | Intravenous |
| Comparator | Ephedrine | Small molecule | 1.2 mg/kg | Intravenous |