HIgh Versus STAndard Blood Pressure Target in Hypertensive High-risk Patients Undergoing Major Abdominal Surgery

Summary

This study is a multicenter randomized controlled trial comparing two strategies of mean arterial blood pressure management (MAP ≥ 80mmHg vs MAP ≥ 65 mmHg) in high-risk surgical patients undergoing elective laparotomic/laparoscopic surgery.

Timeline

Start

2023-03-06

Primary completion

2025-05-21

Completion

2025-05-21

Publications

• Background Messina A, Robba C, Calabro L, Zambelli D, Iannuzzi F, Molinari E, Scarano S, Battaglini D, Baggiani M, De Mattei G, Saderi L, Sotgiu G, Pelosi P, Cecconi M. Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surgery. Crit Care. 2021 Feb 1;25(1):43. doi: 10.1186/s13054-021-03464-1.
• Background Walsh M, Devereaux PJ, Garg AX, Kurz A, Turan A, Rodseth RN, Cywinski J, Thabane L, Sessler DI. Relationship between intraoperative mean arterial pressure and clinical outcomes after noncardiac surgery: toward an empirical definition of hypotension. Anesthesiology. 2013 Sep;119(3):507-15. doi: 10.1097/ALN.0b013e3182a10e26.
• Cecconi M, Cortegiani A, Noto A, Sotgiu G, Antonelli M, Anderloni M, Barbaresco I, Bizzarri F, Brunati A, Cappellini I, Cammarota G, Caporale M, Collino F, Cuschera M, Coloretti I, Donadello K, Foti L, Frassanito L, Fiume D, Girardis M, L'Acqua C, Lauro G, Maggiore SM, Magnoni S, Mirabella L, Misseri G, Miori S, Matronola GM, Pavan G, Pellis T, Piccioni F, Puci MV, Pugliese S, Romano B, Russo A, Samuelli N, Torrano V, Viani A, Jaber S, Azoulay E, Romagnoli S, Messina A; SIAARTI Study Group. HIgh versus STAndard blood Pressure target in hypertensive high-risk patients undergoing elective major abdominal surgery: the HISTAP multicenter randomized clinical trial. Intensive Care Med. 2026 Jun 29. doi: 10.1007/s00134-026-08501-7. Online ahead of print.

Drugs

Indications