drugset / Trial / NCT02033707

Effects of Hallucinogens and Other Drugs on Mood and Performance

NCT02033707 ↗

Phase 1 Completed 20 enrolled Johns Hopkins University

RandomizedParallel-groupTriple-blindBasic science

Summary

This non-treatment study will investigate the effects on mood and performance caused by hallucinogens and other psychoactive compounds.

Timeline

Start: 2014-04
Primary completion: 2019-02
Completion: 2019-02

Publications

Mathai DS, Hilbert S, Sepeda ND, Strickland JC, Griffiths RR, Garcia-Romeu A. Double-Blind Comparison of the Two Hallucinogens Dextromethorphan and Psilocybin: Experience-Dependent and Enduring Psychological Effects in Healthy Volunteers. Psychedelic Med (New Rochelle). 2023 Dec 1;1(4):241-252. doi: 10.1089/psymed.2023.0035. Epub 2023 Dec 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dextromethorphan	Unknown	400 mg	Oral
Subject	Psilocybin	Other / unclassified	10 mg	Oral
Subject	Psilocybin	Other / unclassified	20 mg	Oral
Subject	Psilocybin	Other / unclassified	30 mg	Oral
Background	4-phosphoryloloxy-N-diethyltryptamine	Unknown	—	—
Background	Alcohol	Unknown	—	—
Background	Alprazolam	Small molecule	—	—
Background	Caffeine	Small molecule	—	—
Background	Cannabis	Traditional medicine (herbal / TCM)	—	—
Background	Chlorpheniramine	Unknown	—	—
Background	Codeine	Small molecule	—	—
Background	DMT	Unknown	—	—
Background	Dextroamphetamine	Small molecule	—	—
Background	Diacetylmorphine	Small molecule	—	—
Background	Diazepam	Small molecule	—	—
Background	Diphenhydramine	Small molecule	—	—
Background	Ephedrine	Small molecule	—	—
Background	Hydrocodone	Unknown	—	—
Background	Ketamine	Small molecule	—	—
Background	LSD	Unknown	—	—
Background	Lorazepam	Small molecule	—	—
Background	MDMA	Unknown	—	—
Background	Mescaline	Small molecule	—	—
Background	Methadone	Other / unclassified	—	—
Background	Methylphenidate	Small molecule	—	—
Background	Morphine	Other / unclassified	—	—
Background	Nicotine	Unknown	—	—
Background	Oxycodone	Other / unclassified	—	—
Background	PCP	Unknown	—	—
Background	Salvinorin A	Small molecule	—	—
Background	Scopolamine	Unknown	—	—
Background	Temazepam	Small molecule	—	—
Background	Triazolam	Small molecule	—	—
Background	Zolpidem	Small molecule	—	—
Background	d-lysergic acid amide (LSA)	Unknown	—	—
Background	diethylproprion	Unknown	—	—
Background	dipropyltryptamine (DPT)	Unknown	—	—
Background	secobarbital	Small molecule	—	—

Indications

No indication recorded.