Drugs / Lorazepam
last change Jun 2026 re-read 2 minutes ago

Lorazepam

Small molecule

Developed for
delirium · epilepsy · alcohol dependence · insomnia · schizophrenia · anxiety disorder · generalized anxiety disorder · high grade malignant neoplasm
+18 more · alcohol withdrawal · anxiety · bipolar disorder · cardiac arrest · catatonia · depressive disorder · epilepsy syndrome · poisoning · schizoaffective disorder · substance-related disorder · voice disorders · alcohol withdrawal delirium · benign paroxysmal positional vertigo · manic bipolar affective disorder · mental disorder · peripheral vertigo · photosensitive epilepsy · pregnancy disorder with abortive outcome
Investigated by
National Cancer Institute (NCI) · National Institute of Mental Health (NIMH) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) · GlaxoSmithKline · Pfizer · Sequential Medicine Ltd
+94 more · Kamuzu University of Health Sciences · M.D. Anderson Cancer Center · Maastricht University Medical Center · Merck Sharp & Dohme LLC · National Institute of Neurological Disorders and Stroke (NINDS) · Orasi Medical, Inc. · University of Colorado, Denver · University of Twente · Virginia Commonwealth University · Aalborg University · Academic Medical Center - University of Amsterdam · Alexza Pharmaceuticals, Inc. · American Academy of Clinical Toxicology · American Cancer Society, Inc. · Assistance Publique Hopitaux De Marseille · AstraZeneca · Australasian Leukaemia and Lymphoma Group · Bambino Gesù Hospital and Research Institute · Belgium Health Care Knowledge Centre · California Institute of Technology · Canisius-Wilhelmina Hospital · Children's Hospital Los Angeles · Clinilabs, Inc. · Edgemont Pharmaceuticals, LLC · Eli Lilly and Company · Emory University · Erasme University Hospital · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · German Federal Ministry of Education and Research · German Research Network On Schizophrenia · Hamilton Health Sciences Corporation · Hannover Medical School · Heinrich-Heine University, Duesseldorf · Humboldt-Universität zu Berlin · Janssen-Cilag Ltd. · John Templeton Foundation · Laureate Institute for Brain Research, Inc. · Ludwig-Maximilians - University of Munich · Lundbeck LLC · Maasstad Hospital · Mainz University · Makerere University · Maria Pacella · Martin-Luther-University Halle-Wittenberg · Massachusetts General Hospital · Mayo Clinic · McMaster University · Mclean Hospital · Medisch Spectrum Twente · Ministero della Salute, Italy · Mylan Pharmaceuticals Inc · Nathan Kline Institute for Psychiatric Research · National Institute on Drug Abuse (NIDA) · New York State Psychiatric Institute · Northwell Health · Planned Parenthood League of Massachusetts · RWTH Aachen University · Radboud University Medical Center · Rijnstate Hospital · Seoul National University Hospital · St. Antonius Hospital · The Cooper Health System · The Emmes Company, LLC · UCB Pharma · University College, London · University Health Network, Toronto · University Hospital Tuebingen · University Hospital, Basel, Switzerland · University Hospital, Strasbourg, France · University Medical Center Groningen · University of Bonn · University of California, Los Angeles · University of California, San Francisco · University of Cologne · all 100 on the full record

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) ATIVAN 1997-09-05 fda.gov
Approved US (FDA) ATIVAN 1977-09-30 fda.gov

Trials 67 · started per year

today
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19771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT07560878 Mar 2026 → Dec 2030 expected major depressive disorder Mclean Hospital Recruiting No outcome recorded
Phase 0 NCT04671836 Jan → Dec 2022 Northwell Health Withdrawn No outcome recorded
Phase 0 NCT04923659 May 2021 → Jul 2022 overdue University Health Network, Toronto Active not recruiting No outcome recorded
Phase 114 trials
Phase 1 NCT03053869 Apr 2017 → Sep 2018 delirium McMaster University Completed No outcome recorded
Phase 1 NCT01994668 Jan → Feb 2014 Pfizer Completed No outcome recorded
Phase 1 NCT01951144 Oct 2013 → Jul 2014 Pfizer Completed No outcome recorded
Phase 1 NCT02462109 Mar 2013 catatonia Makerere University Completed No outcome recorded
Phase 1 NCT01780519 Jan 2013 → Sep 2016 Alzheimer disease Mayo Clinic Completed No outcome recorded
Phase 1 NCT01275144 Dec 2010 → Feb 2011 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01110616 Jun → Oct 2010 dementia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT00826553 Jan 2009 → Dec 2013 delirium, respiratory failure Vanderbilt University Medical Center Terminated No outcome recorded
Phase 1 NCT00720421 Jun → Aug 2008 AstraZeneca Completed No outcome recorded
Phase 1 NCT00513565 Sep 2007 → May 2009 mixed anxiety and depressive disorder GlaxoSmithKline Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00123578 Aug 2004 → Aug 2008 substance-related disorder University of California, Los Angeles Withdrawn No outcome recorded
Phase 210 trials
Phase 2 NCT06496854 Oct 2025 → Jan 2026 University of Wisconsin, Madison Withdrawn No outcome recorded
Phase 2 NCT05662228 Jun 2023 → May 2026 Down syndrome University of Colorado, Denver Completed No outcome recorded
Phase 2 NCT04646135 Dec 2020 → Jul 2021 Bambino Gesù Hospital and Research Institute Unknown No outcome recorded
Phase 2 NCT03756038 Jan → Mar 2019 Maria Pacella Terminated No outcome recorded
Phase 2 NCT02671760 Feb → Jun 2016 insomnia Sequential Medicine Ltd Completed No outcome recorded
Phase 2 NCT01949662 Jan 2014 → Aug 2016 overdue high grade malignant neoplasm M.D. Anderson Cancer Center Active not recruiting No outcome recorded
Phase 2 NCT01790490 Feb 2011 → Mar 2012 cocaine dependence New York State Psychiatric Institute Completed No outcome recorded
Phase 2 NCT00429702 Oct 2007 → Aug 2009 childhood malignant neoplasm University of South Florida Terminated No outcome recorded
Phase 2 NCT00229125 Jul 2001 → Sep 2005 alcohol withdrawal National Institute on Alcohol Abuse and Alcoholism (NIAAA) Completed No outcome recorded
Phase 2 NCT00011297 ? → Dec 2005 alcohol dependence National Institute on Alcohol Abuse and Alcoholism (NIAAA) Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT03743649 Jul 2019 → Dec 2028 expected delirium, high grade malignant neoplasm, metastatic malignant neoplasm M.D. Anderson Cancer Center Active not recruiting No outcome recorded
Phase 2/3 NCT00465244 Jan 2008 → May 2010 epilepsy Massachusetts General Hospital Withdrawn No outcome recorded
Phase 311 trials
Phase 3 NCT07017452 Aug → Dec 2025 overdue benign prostatic hyperplasia University of Manitoba Not yet recruiting No outcome recorded
Phase 3 NCT03338764 May → Dec 2023 insomnia Sequential Medicine Ltd Withdrawn No outcome recorded
Phase 3 NCT03331042 Oct 2017 → Mar 2018 insomnia Sequential Medicine Ltd Completed No outcome recorded
Phase 3 NCT02305797 Jan 2015 → May 2016 generalized anxiety disorder Edgemont Pharmaceuticals, LLC Completed No outcome recorded
Phase 3 NCT02374567 Jan 2015 → Jun 2017 anxiety disorder, dementia, depressive disorder, schizophrenia +1 Hannover Medical School Terminated No outcome recorded
Phase 3 NCT02239380 Nov 2014 → Aug 2016 Pfizer Completed No outcome recorded
Phase 3 NCT02134366 Jul 2014 → Jul 2017 epilepsy syndrome The Cooper Health System Terminated No outcome recorded
Phase 3 NCT01901003 Nov 2012 → Jun 2014 Assistance Publique Hopitaux De Marseille Completed No outcome recorded
Phase 3 NCT00343096 Jun 2006 → Mar 2009 epilepsy Kamuzu University of Health Sciences Terminated No outcome recorded
Phase 3 NCT00116064 Jul 2004 → Jun 2005 epilepsy Kamuzu University of Health Sciences Completed No outcome recorded
Phase 413 trials
Phase 4 NCT07428681 Mar 2027 → Feb 2028 expected delirium University Hospital, Basel, Switzerland Not yet recruiting No outcome recorded
Phase 4 NCT06852469 Jul 2025 → Jun 2029 expected post-traumatic stress disorder VA Office of Research and Development Recruiting No outcome recorded
Phase 4 NCT06004115 Nov 2023 → Dec 2027 expected anxiety, mixed anxiety and depressive disorder Laureate Institute for Brain Research, Inc. Recruiting No outcome recorded
Phase 4 NCT04004416 Jan 2020 → Feb 2025 bipolar disorder, major depressive disorder, schizoaffective disorder, schizophrenia +1 University of Michigan Completed No outcome recorded
Phase 4 NCT03090620 Mar 2017 → Jul 2020 poisoning University of Colorado, Denver Completed No outcome recorded
Phase 4 NCT01889602 Jul 2013 → Aug 2016 cognitive disorder University of Minnesota Completed No outcome recorded
Phase 4 NCT01877642 Jun → Jul 2013 Alexza Pharmaceuticals, Inc. Completed No outcome recorded
Phase 4 NCT01121055 Mar → Aug 2010 Seoul National University Hospital Unknown No outcome recorded
Phase 4 NCT00721526 Aug 2009 → Aug 2012 alcohol dependence, anxiety disorder University of New Mexico Completed No outcome recorded
Phase 4 NCT00158873 Sep 2004 → ? GlaxoSmithKline Completed No outcome recorded
Phase not applicable13 trials
NCT06549426 Apr 2025 → Dec 2029 expected epilepsy University of Twente Recruiting No outcome recorded
NCT02928328 Oct 2016 → Dec 2018 Aalborg University Unknown No outcome recorded
NCT02863614 May 2015 → May 2017 infertility disorder University of Sao Paulo Completed No outcome recorded
NCT02056236 Apr 2014 → Apr 2021 cardiac arrest University of Twente Completed No outcome recorded
NCT01556932 Mar 2012 → May 2013 Virginia Commonwealth University Completed No outcome recorded
NCT01843868 Jan 2012 → Jun 2015 non-Hodgkin lymphoma Australasian Leukaemia and Lymphoma Group Withdrawn No outcome recorded
NCT01204255 Nov 2010 → Apr 2011 Virginia Commonwealth University Completed No outcome recorded
NCT01272778 Oct 2010 → Apr 2011 Orasi Medical, Inc. Unknown No outcome recorded
NCT00972985 Sep → Dec 2009 Orasi Medical, Inc. Completed No outcome recorded
NCT01566539 Apr 2008 → Nov 2016 Emory University Completed No outcome recorded
Also used as a comparator or background therapy in 65 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT00881556 Background Aug 2009 → Sep 2015 epidermolysis bullosa Columbia University Terminated No outcome recorded
Phase 18 trials
Phase 1 NCT05964647 Comparator Feb 2024 → Jun 2025 University Hospital, Basel, Switzerland Completed No outcome recorded
Phase 1 NCT03300947 Comparator Jan 2019 → Oct 2023 obsessive-compulsive disorder University of Arizona Completed No outcome recorded
Phase 1 NCT03829839 Comparator Mar 2016 → Aug 2017 University Hospital, Bonn Completed No outcome recorded
Phase 1 NCT02033707 Background Apr 2014 → Feb 2019 Johns Hopkins University Completed No outcome recorded
Phase 1 NCT00902772 Comparator May → Sep 2009 AstraZeneca Completed No outcome recorded
Phase 29 trials
Phase 2 NCT06859424 Background Jul 2025 → Jun 2028 expected B-cell chronic lymphocytic leukemia, acute myeloid leukemia, chronic myeloid leukemia, chronic myelomonocytic leukemia +3 Center for International Blood and Marrow Transplant Research Recruiting No outcome recorded
Phase 2 NCT04715230 Comparator Jun 2021 → Oct 2022 methamphetamine-induced psychosis InterveXion Therapeutics, LLC Terminated No outcome recorded
Phase 2 NCT04396327 Background May → Jun 2020 overdue insomnia Sequential Medicine Ltd Not yet recruiting No outcome recorded
Phase 2 NCT03180632 Comparator Jun 2017 → Jun 2018 anxiety St. Justine's Hospital Completed No outcome recorded
Phase 2 NCT03021018 Comparator Feb 2017 → Apr 2018 epilepsy UCB Biopharma S.P.R.L. Completed No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT06752616 Comparator Dec 2024 → Dec 2027 expected Lone Baandrup Recruiting No outcome recorded
Phase 2/3 NCT00621478 Comparator Feb 2008 → May 2012 Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Completed No outcome recorded
Phase 2/3 NCT00109395 Comparator Sep 2004 → Sep 2007 The Emmes Company, LLC Completed No outcome recorded
Phase 38 trials
Phase 3 NCT06370442 Comparator Jun 2024 → May 2025 mental disorder State University of New York - Upstate Medical University Unknown No outcome recorded
Phase 3 NCT02147548 Comparator Dec 2013 → Oct 2015 Biocodex Completed No outcome recorded
Phase 3 NCT01870024 Comparator Jun 2013 → Feb 2018 epilepsy Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 3 NCT01827293 Comparator Apr → Jun 2013 peripheral vertigo Shahid Beheshti University of Medical Sciences Completed No outcome recorded
Phase 3 NCT01067144 Comparator May 2010 → Jul 2016 breast cancer, lung cancer Stanford University Terminated No outcome recorded
Phase 424 trials
Phase 4 NCT07552246 Background Apr 2026 → Mar 2027 expected mixed anxiety and depressive disorder Duke Kunshan University Not yet recruiting No outcome recorded
Phase 4 NCT06799494 Background Aug 2025 → Sep 2028 expected human papilloma virus infection Emory University Recruiting No outcome recorded
Phase 4 NCT06429657 Background Sep 2024 → Jan 2027 intracerebral hemorrhage, intracranial hypertension, traumatic brain injury Henry M. Jackson Foundation for the Advancement of Military Medicine Suspended No outcome recorded
Phase 4 NCT05599126 Comparator Jul 2024 → Dec 2025 depressive disorder Zhenghui YI Unknown No outcome recorded
Phase 4 NCT06093451 Comparator Jul 2023 → Jul 2024 bipolar disorder, schizoaffective disorder, schizophrenia Temple University Unknown No outcome recorded
Phase not applicable12 trials
NCT06467474 Background Mar 2024 → Jun 2025 overdue major depressive disorder Ricardo Alberto Moreno, M.D., Ph.D. Recruiting No outcome recorded
NCT02362256 Background May → Jun 2014 opiate dependence Vilnius University Completed No outcome recorded
NCT02312739 Comparator Feb 2014 → Mar 2015 University of New Mexico Completed No outcome recorded
NCT01393288 Comparator Nov 2013 → Nov 2014 University of California, San Francisco Withdrawn No outcome recorded
NCT01684085 Comparator Oct 2012 → Sep 2014 post-traumatic stress disorder Sheba Medical Center Unknown No outcome recorded

Evidence & citations 17 cited values

Every value below carries the sentence it was read from. 134 sources stand behind the page.

FieldValueCited text
Known as Lorazépam “Standard of Care analgosedation of choice using propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam administered according to the...” NCT06429657
127

“Intravenous moderate sedation (fentanyl 100 mcg and midazolam 2 mg) versus oral analgesia/anxiolysis (lorazepam 2 mg sublingual, hydrocodone/acetaminophen 5/500 mg, and...” NCT01011634

“Administer Toludesvenlafaxine (40-80 mg daily) or imported Sertraline (50-200 mg daily), supplemented with Lorazepam (0.4-0.8 mg) or Alprazolam (0.4-0.8 mg) as needed for sleep support.” NCT07552246

“For the purposes of enrollment and analysis all benzodiazepines used for sedation (mainly midazolam and lorazepam) will be considered equivalent.” NCT00826553

“3-drug combination product containing 50-mg diphenhydramine, 5-mg delayed-release zolpidem and 0.5-mg delayed-release lorazepam.” NCT03331042

“Anti-emetics (metoclopramide, prochlorperazine and lorazepam) may be prescribed to be used 'as needed' for breakthrough emesis.” NCT01843868

“Subjects will receive busulfan seizure prophylaxis with levetiracetam, fosphenytoin, or lorazepam per institutional guidelines.” NCT06859424

“The effect of intramuscular injection of GABA or lorazepam will be compared with buffered isotonic saline” NCT02928328

“Sedatives/anxiolytics: alprazolam, diazepam, lorazepam, secobarbital, temazepam, triazolam, zolpidem” NCT02033707

“Subjects will receive single doses of GSK561679, lorazepam, or placebo at each treatment session.” NCT00513565

“3-drug combination product containing 50 mg diphenhydramine, 5 mg zolpidem and 0.5 mg lorazepam” NCT04396327

“3-drug combination product containing 50 mg diphenhydramine, 5 mg zolpidem and 0.5 mg lorazepam” NCT02671760

“SM-1 is a combination drug product containing diphenhydramine, zolpidem and lorazepam.” NCT03338764

“Lorazepam is a benzodiazepine that is widely used for management of acute agitation.” PMID 33692709 Feb 2021

“the following benzodiazepines (bolus + continuous infusion): lorazepam or midazolam” NCT02056236

“Associations with Lorazepam if necessary will be allowed in any phase of the study.” NCT06467474

“a single dose of a parenteral benzodiazepine (lorazepam, midazolam, or diazepam)” NCT06549426

Lorazépam drug (0,038 mg/kg) on a single oral intake” NCT00696033

“- Lorazepam 1-10 mg/d. N05BA06” NCT01305707

“the benzodiazepine lorazepam” NCT01050478

“Lorazepam OR Levetaracetam” NCT01505569

“one 1mg Lorazepam tablet” NCT02312739

NCT00159133

NCT00720421

NCT07017452

NCT00881556

NCT00364429

NCT07560878

NCT02239380

NCT01901003

NCT06799494

NCT01566539

NCT02078336

NCT00114569

NCT02134366

NCT02305797

NCT05964647

NCT00735527

NCT00249366

NCT06093451

NCT00123578

NCT03829839

NCT01272778

NCT00641797

NCT01827293

NCT03021018

NCT02147548

NCT00004297

NCT07428681

NCT00649818

NCT00696033

NCT02367755

NCT02863614

NCT05599126

NCT03756038

NCT01949662

NCT03180632

NCT03202550

NCT01330459

NCT00586430

NCT00044642

NCT04671836

NCT02564029

NCT01870024

NCT01204255

NCT00523185

NCT01393288

NCT00807937

NCT01951144

NCT00465244

NCT04004416

NCT04646135

NCT06004115

NCT00621478

NCT00109395

NCT00343096

NCT00424697

NCT05662228

NCT00750802

NCT00721526

NCT04923659

NCT00337792

NCT00431184

NCT01556932

NCT00000441

NCT03110900

NCT02362256

NCT00116064

NCT03012815

NCT03435692

NCT01994668

NCT01067144

NCT01780519

NCT01877642

NCT00972985

NCT02374567

NCT02462109

NCT01889602

NCT00158873

NCT04715230

NCT01441843

NCT00797277

NCT06496854

NCT03090620

NCT00597701

NCT00715039

NCT01110616

NCT03300947

NCT06752616

NCT03743649

NCT00011297

NCT00736931

NCT00229125

NCT01121055

NCT04156464

NCT02407704

NCT00902772

NCT01275144

NCT00846950

NCT03235531

NCT01790490

NCT01684085

NCT00055549

NCT06852469

NCT00624780

NCT03788889

NCT00457366

NCT00095251

Known as Abbloraz ChEMBL registry synonym — accepted as the source's own label CHEMBL580
Known as Ativan “Gabapentin (Neurontin) will be compared to a standard benzodiazepine, lorazepam (Ativan), for its effectiveness in treating alcohol withdrawal.” NCT00011297
5

“Haldol 5mg/ Ativan 2mg IM” NCT00786318

“Xanax, Valium, AtivanNCT03053869

“lorazepam (Ativan)” NCT00000441

NCT04240626

NCT00429702

Known as Intravenous route of active treatment ClinicalTrials.gov intervention name — accepted as the source's own label NCT00809146
Known as Loraz ChEMBL registry synonym — accepted as the source's own label CHEMBL580
Known as Lorazepam civ ChEMBL registry synonym — accepted as the source's own label CHEMBL580
Known as Lorazepam intensol ChEMBL registry synonym — accepted as the source's own label CHEMBL580
Known as Lorazepam Mylan Lorazepam Mylan 2,5 mg tabletten 2.5mg Oral use Single dose 45 minutes before dental treatment” NCT02078336
Known as Lorazepam preservative free ChEMBL registry synonym — accepted as the source's own label CHEMBL580
Known as Loreev xr ChEMBL registry synonym — accepted as the source's own label CHEMBL580
Known as LZP “comparing acute dosing (i.e., two doses) of BRV 10 mg, LEV 500 mg, lorazepam (LZP) 2 mg, and placebo.” PMID 20887370 Sep 2010
1

“one (1) dose of a comparator drug (lorazepam-LZP)” NCT01889602

Known as NSC-289758 ChEMBL registry synonym — accepted as the source's own label CHEMBL580
Known as Temesta ChEMBL registry synonym — accepted as the source's own label CHEMBL580
Known as WY-4036 ChEMBL registry synonym — accepted as the source's own label CHEMBL580
Action Activate “standard use of GABA agonist sedatives such as lorazepam” NCT00095251
Modality Small molecule “a standard benzodiazepine, lorazepam (Ativan)” NCT00011297
Route Intravenous “Patients receive intravenous diazepam, lorazepam, or placebo during transport.” NCT00004297