Drugs / Lorazepam
last change Jun 2026 re-read 8 days ago

Lorazepam

Small molecule

Developed for
delirium · epilepsy · alcohol dependence · insomnia · schizophrenia · anxiety disorder · generalized anxiety disorder · high grade malignant neoplasm
+18 more · alcohol withdrawal · anxiety · bipolar disorder · cardiac arrest · catatonia · depressive disorder · epilepsy syndrome · poisoning · schizoaffective disorder · substance-related disorder · voice disorders · alcohol withdrawal delirium · benign paroxysmal positional vertigo · manic bipolar affective disorder · mental disorder · peripheral vertigo · photosensitive epilepsy · pregnancy disorder with abortive outcome
Investigated by
National Cancer Institute (NCI) · National Institute of Mental Health (NIMH) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) · GlaxoSmithKline · Pfizer · Sequential Medicine Ltd
+94 more · Kamuzu University of Health Sciences · M.D. Anderson Cancer Center · Maastricht University Medical Center · Merck Sharp & Dohme LLC · National Institute of Neurological Disorders and Stroke (NINDS) · Orasi Medical, Inc. · University of Colorado, Denver · University of Twente · Virginia Commonwealth University · Aalborg University · Academic Medical Center - University of Amsterdam · Alexza Pharmaceuticals, Inc. · American Academy of Clinical Toxicology · American Cancer Society, Inc. · Assistance Publique Hopitaux De Marseille · AstraZeneca · Australasian Leukaemia and Lymphoma Group · Bambino Gesù Hospital and Research Institute · Belgium Health Care Knowledge Centre · California Institute of Technology · Canisius-Wilhelmina Hospital · Children's Hospital Los Angeles · Clinilabs, Inc. · Edgemont Pharmaceuticals, LLC · Eli Lilly and Company · Emory University · Erasme University Hospital · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · German Federal Ministry of Education and Research · German Research Network On Schizophrenia · Hamilton Health Sciences Corporation · Hannover Medical School · Heinrich-Heine University, Duesseldorf · Humboldt-Universität zu Berlin · Janssen-Cilag Ltd. · John Templeton Foundation · Laureate Institute for Brain Research, Inc. · Ludwig-Maximilians - University of Munich · Lundbeck LLC · Maasstad Hospital · Mainz University · Makerere University · Maria Pacella · Martin-Luther-University Halle-Wittenberg · Massachusetts General Hospital · Mayo Clinic · McMaster University · Mclean Hospital · Medisch Spectrum Twente · Ministero della Salute, Italy · Mylan Pharmaceuticals Inc · Nathan Kline Institute for Psychiatric Research · National Institute on Drug Abuse (NIDA) · New York State Psychiatric Institute · Northwell Health · Planned Parenthood League of Massachusetts · RWTH Aachen University · Radboud University Medical Center · Rijnstate Hospital · Seoul National University Hospital · St. Antonius Hospital · The Cooper Health System · The Emmes Company, LLC · UCB Pharma · University College, London · University Health Network, Toronto · University Hospital Tuebingen · University Hospital, Basel, Switzerland · University Hospital, Strasbourg, France · University Medical Center Groningen · University of Bonn · University of California, Los Angeles · University of California, San Francisco · University of Cologne · all 100 on the full record

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) ATIVAN — 1997-09-05 fda.gov ↗
Approved US (FDA) ATIVAN — 1977-09-30 fda.gov ↗

Trials 67 · started per year

today
US approved 1977
1
2
2
1
4
2
3
4
3
3
5
1
3
5
5
3
2
3
2
2
1
1
3
4
1
1
19771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT07560878 Mar 2026 → Dec 2030 expected major depressive disorder Mclean Hospital Recruiting No outcome recorded
Phase 0 NCT04671836 Jan → Dec 2022 — Northwell Health Withdrawn No outcome recorded
Phase 0 NCT04923659 May 2021 → Jul 2022 overdue — University Health Network, Toronto Active not recruiting No outcome recorded
Phase 114 trials
Phase 1 NCT03053869 Apr 2017 → Sep 2018 delirium McMaster University Completed No outcome recorded
Phase 1 NCT01994668 Jan → Feb 2014 — Pfizer Completed No outcome recorded
Phase 1 NCT01951144 Oct 2013 → Jul 2014 — Pfizer Completed No outcome recorded
Phase 1 NCT02462109 Mar 2013 catatonia Makerere University Completed No outcome recorded
Phase 1 NCT01780519 Jan 2013 → Sep 2016 Alzheimer disease Mayo Clinic Completed No outcome recorded
Phase 1 NCT01275144 Dec 2010 → Feb 2011 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01110616 Jun → Oct 2010 dementia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT00826553 Jan 2009 → Dec 2013 delirium, respiratory failure Vanderbilt University Medical Center Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT00720421 Jun → Aug 2008 — AstraZeneca Completed No outcome recorded
Phase 1 NCT00513565 Sep 2007 → May 2009 mixed anxiety and depressive disorder GlaxoSmithKline Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00123578 Aug 2004 → Aug 2008 substance-related disorder University of California, Los Angeles Withdrawn No outcome recorded Stop: Enrollment
Phase 210 trials · 1 met primary
Phase 2 NCT06496854 Oct 2025 → Jan 2026 — University of Wisconsin, Madison Withdrawn No outcome recorded
Phase 2 NCT05662228 Jun 2023 → May 2026 Down syndrome University of Colorado, Denver Completed No outcome recorded
Phase 2 NCT04646135 Dec 2020 → Jul 2021 — Bambino Gesù Hospital and Research Institute Unknown No outcome recorded
Phase 2 NCT03756038 Jan → Mar 2019 — Maria Pacella Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT02671760 Feb → Jun 2016 insomnia Sequential Medicine Ltd Completed No outcome recorded
Phase 2 NCT01949662 Jan 2014 → Aug 2016 overdue high grade malignant neoplasm M.D. Anderson Cancer Center Active not recruiting Met primary
Phase 2 NCT01790490 Feb 2011 → Mar 2012 cocaine dependence New York State Psychiatric Institute Completed No outcome recorded
Phase 2 NCT00429702 Oct 2007 → Aug 2009 childhood malignant neoplasm University of South Florida Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT00229125 Jul 2001 → Sep 2005 alcohol withdrawal National Institute on Alcohol Abuse and Alcoholism (NIAAA) Completed No outcome recorded
Phase 2 NCT00011297 ? → Dec 2005 alcohol dependence National Institute on Alcohol Abuse and Alcoholism (NIAAA) Completed No outcome recorded
Phase 2/32 trials · 1 met primary
Phase 2/3 NCT03743649 Jul 2019 → Dec 2028 expected delirium, high grade malignant neoplasm, metastatic malignant neoplasm M.D. Anderson Cancer Center Active not recruiting Met primary
Phase 2/3 NCT00465244 Jan 2008 → May 2010 epilepsy Massachusetts General Hospital Withdrawn No outcome recorded Stop: Enrollment
Phase 311 trials · 1 missed
Phase 3 NCT07017452 Aug → Dec 2025 overdue benign prostatic hyperplasia University of Manitoba Not yet recruiting No outcome recorded
Phase 3 NCT03338764 May → Dec 2023 insomnia Sequential Medicine Ltd Withdrawn No outcome recorded Stop: Enrollment
Phase 3 NCT03331042 Oct 2017 → Mar 2018 insomnia Sequential Medicine Ltd Completed No outcome recorded
Phase 3 NCT02305797 Jan 2015 → May 2016 generalized anxiety disorder Edgemont Pharmaceuticals, LLC Completed No outcome recorded
Phase 3 NCT02374567 Jan 2015 → Jun 2017 anxiety disorder, dementia, depressive disorder, schizophrenia +1 Hannover Medical School Terminated No outcome recorded
Phase 3 NCT02239380 Nov 2014 → Aug 2016 — Pfizer Completed No outcome recorded
Phase 3 NCT02134366 Jul 2014 → Jul 2017 epilepsy syndrome The Cooper Health System Terminated No outcome recorded Stop: Enrollment
Phase 3 NCT01901003 Nov 2012 → Jun 2014 — Assistance Publique Hopitaux De Marseille Completed Missed primary
Phase 3 NCT00343096 Jun 2006 → Mar 2009 epilepsy Kamuzu University of Health Sciences Terminated No outcome recorded
Phase 3 NCT00116064 Jul 2004 → Jun 2005 epilepsy Kamuzu University of Health Sciences Completed No outcome recorded
Phase 413 trials · 1 met primary
Phase 4 NCT07428681 Mar 2027 → Feb 2028 expected delirium University Hospital, Basel, Switzerland Not yet recruiting No outcome recorded
Phase 4 NCT06852469 Jul 2025 → Jun 2029 expected post-traumatic stress disorder VA Office of Research and Development Recruiting No outcome recorded
Phase 4 NCT06004115 Nov 2023 → Dec 2027 expected anxiety, mixed anxiety and depressive disorder Laureate Institute for Brain Research, Inc. Recruiting No outcome recorded
Phase 4 NCT04004416 Jan 2020 → Feb 2025 bipolar disorder, major depressive disorder, schizoaffective disorder, schizophrenia +1 University of Michigan Completed No outcome recorded
Phase 4 NCT03090620 Mar 2017 → Jul 2020 poisoning University of Colorado, Denver Completed No outcome recorded
Phase 4 NCT01889602 Jul 2013 → Aug 2016 cognitive disorder University of Minnesota Completed No outcome recorded
Phase 4 NCT01877642 Jun → Jul 2013 — Alexza Pharmaceuticals, Inc. Completed Met primary
Phase 4 NCT01121055 Mar → Aug 2010 — Seoul National University Hospital Unknown No outcome recorded
Phase 4 NCT00721526 Aug 2009 → Aug 2012 alcohol dependence, anxiety disorder University of New Mexico Completed No outcome recorded
Phase 4 NCT00158873 Sep 2004 → ? — GlaxoSmithKline Completed No outcome recorded
Phase not applicable13 trials · 2 missed
— NCT06549426 Apr 2025 → Dec 2029 expected epilepsy University of Twente Recruiting No outcome recorded
— NCT02928328 Oct 2016 → Dec 2018 — Aalborg University Unknown No outcome recorded
— NCT02863614 May 2015 → May 2017 infertility disorder University of Sao Paulo Completed No outcome recorded
— NCT02056236 Apr 2014 → Apr 2021 cardiac arrest University of Twente Completed Missed primary
— NCT01556932 Mar 2012 → May 2013 — Virginia Commonwealth University Completed No outcome recorded
— NCT01843868 Jan 2012 → Jun 2015 non-Hodgkin lymphoma Australasian Leukaemia and Lymphoma Group Withdrawn No outcome recorded Stop: Enrollment
— NCT01204255 Nov 2010 → Apr 2011 — Virginia Commonwealth University Completed No outcome recorded
— NCT01272778 Oct 2010 → Apr 2011 — Orasi Medical, Inc. Unknown No outcome recorded
— NCT00972985 Sep → Dec 2009 — Orasi Medical, Inc. Completed No outcome recorded
— NCT01566539 Apr 2008 → Nov 2016 — Emory University Completed No outcome recorded
Comparator or background therapy64 trials
Phase 0 NCT00881556 Background Aug 2009 → Sep 2015 epidermolysis bullosa Columbia University Terminated No outcome recorded
Phase 1 NCT05964647 Comparator Feb 2024 → Jun 2025 — University Hospital, Basel, Switzerland Completed No outcome recorded
Phase 1 NCT03300947 Comparator Jan 2019 → Oct 2023 obsessive-compulsive disorder University of Arizona Completed No outcome recorded
Phase 1 NCT03829839 Comparator Mar 2016 → Aug 2017 — University Hospital, Bonn Completed No outcome recorded
Phase 1 NCT02033707 Background Apr 2014 → Feb 2019 — Johns Hopkins University Completed No outcome recorded

Evidence & citations 16 cited values

Every value below carries the sentence it was read from. 133 sources stand behind the page.

FieldValueCited text
Known as Lorazépam “Standard of Care analgosedation of choice using propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam administered according to the...” NCT06429657 ↗
127

“Intravenous moderate sedation (fentanyl 100 mcg and midazolam 2 mg) versus oral analgesia/anxiolysis (lorazepam 2 mg sublingual, hydrocodone/acetaminophen 5/500 mg, and...” NCT01011634 ↗

“Administer Toludesvenlafaxine (40-80 mg daily) or imported Sertraline (50-200 mg daily), supplemented with Lorazepam (0.4-0.8 mg) or Alprazolam (0.4-0.8 mg) as needed for sleep support.” NCT07552246 ↗

“For the purposes of enrollment and analysis all benzodiazepines used for sedation (mainly midazolam and lorazepam) will be considered equivalent.” NCT00826553 ↗

“3-drug combination product containing 50-mg diphenhydramine, 5-mg delayed-release zolpidem and 0.5-mg delayed-release lorazepam.” NCT03331042 ↗

“Anti-emetics (metoclopramide, prochlorperazine and lorazepam) may be prescribed to be used 'as needed' for breakthrough emesis.” NCT01843868 ↗

“Subjects will receive busulfan seizure prophylaxis with levetiracetam, fosphenytoin, or lorazepam per institutional guidelines.” NCT06859424 ↗

“The effect of intramuscular injection of GABA or lorazepam will be compared with buffered isotonic saline” NCT02928328 ↗

“Sedatives/anxiolytics: alprazolam, diazepam, lorazepam, secobarbital, temazepam, triazolam, zolpidem” NCT02033707 ↗

“Subjects will receive single doses of GSK561679, lorazepam, or placebo at each treatment session.” NCT00513565 ↗

“3-drug combination product containing 50 mg diphenhydramine, 5 mg zolpidem and 0.5 mg lorazepam” NCT02671760 ↗

Show 117 more sources

Known as Abbloraz ChEMBL registry synonym — accepted as the source's own label CHEMBL580 ↗
Known as Ativan “Gabapentin (Neurontin) will be compared to a standard benzodiazepine, lorazepam (Ativan), for its effectiveness in treating alcohol withdrawal.” NCT00011297 ↗
5

“Haldol 5mg/ Ativan 2mg IM” NCT00786318 ↗

“Xanax, Valium, Ativan” NCT03053869 ↗

“lorazepam (Ativan)” NCT00000441 ↗

NCT00429702 ↗

NCT04240626 ↗

Known as Loraz ChEMBL registry synonym — accepted as the source's own label CHEMBL580 ↗
Known as Lorazepam civ ChEMBL registry synonym — accepted as the source's own label CHEMBL580 ↗
Known as Lorazepam intensol ChEMBL registry synonym — accepted as the source's own label CHEMBL580 ↗
Known as Lorazepam Mylan “Lorazepam Mylan 2,5 mg tabletten 2.5mg Oral use Single dose 45 minutes before dental treatment” NCT02078336 ↗
Known as Lorazepam preservative free ChEMBL registry synonym — accepted as the source's own label CHEMBL580 ↗
Known as Loreev xr ChEMBL registry synonym — accepted as the source's own label CHEMBL580 ↗
Known as LZP “comparing acute dosing (i.e., two doses) of BRV 10 mg, LEV 500 mg, lorazepam (LZP) 2 mg, and placebo.” PMID 20887370 ↗ Sep 2010
1

“one (1) dose of a comparator drug (lorazepam-LZP)” NCT01889602 ↗

Known as NSC-289758 ChEMBL registry synonym — accepted as the source's own label CHEMBL580 ↗
Known as Temesta ChEMBL registry synonym — accepted as the source's own label CHEMBL580 ↗
Known as WY-4036 ChEMBL registry synonym — accepted as the source's own label CHEMBL580 ↗
Action Activate “standard use of GABA agonist sedatives such as lorazepam” NCT00095251 ↗
Modality Small molecule “a standard benzodiazepine, lorazepam (Ativan)” NCT00011297 ↗
Route Intravenous “Patients receive intravenous diazepam, lorazepam, or placebo during transport.” NCT00004297 ↗