drugset / Trial / NCT02367755
Therapeutic Hypothermia With Propofol in Survival and Neurological Prognoses After Cardiac Arrest
RandomizedParallel-groupOpen-labelTreatment
Summary
Therapeutic hypothermia has been proven to significantly improve the survival and neurological prognoses in patients resuscitated from cardiac arrest. Propofol has been reported to exhibit potentials in mitigating ischemia-reperfusion injury via the antioxidative, anti-inflammatory and neuroprotective mechanisms. This study is to investigate the potentials of propofol in further improving the survival and neurological prognoses in this era of therapeutic hypothermia.
Timeline
- Start
- 2013-08
- Primary completion
- 2016-12
- Completion
- 2016-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Lorazepam | Small molecule | 0.5 mg/kg | — |
| Subject | Propofol | Small molecule | 3 mg/kg | — |