drugset / Trial / NCT02367755

Therapeutic Hypothermia With Propofol in Survival and Neurological Prognoses After Cardiac Arrest

NCT02367755

Phase 4 Unknown 30 enrolled Far Eastern Memorial Hospital
RandomizedParallel-groupOpen-labelTreatment

Summary

Therapeutic hypothermia has been proven to significantly improve the survival and neurological prognoses in patients resuscitated from cardiac arrest. Propofol has been reported to exhibit potentials in mitigating ischemia-reperfusion injury via the antioxidative, anti-inflammatory and neuroprotective mechanisms. This study is to investigate the potentials of propofol in further improving the survival and neurological prognoses in this era of therapeutic hypothermia.

Timeline

Start
2013-08
Primary completion
2016-12
Completion
2016-12

Drugs

EvaluationDrugModalityDoseRoute
Comparator Lorazepam Small molecule 0.5 mg/kg
Subject Propofol Small molecule 3 mg/kg

Indications