Continuation Electroconvulsive Therapy (C-ECT) for Relapse Prevention in Major Depression
Summary
OBJECTIVES: To evaluate the comparative efficacy and security of Continuation Electroconvulsive Therapy associated with pharmacotherapy versus pharmacotherapy alone in the prevention of depressive relapse. METHODS: Demographic and clinical variables will be collected and side effects scales and neurocognitive battery will be performed. Variables of efficacy: relapse percentage in both groups in one year (primary variable); time without relapse. Main variable of security: occurrence of side effects and neurocognitive performance. DESIGN: Randomized controlled clinical trial. SAMPLE: 104 outpatients diagnosed with unipolar depression (DSM-IV-R criteria) who had remitted with a course of bilateral ECT. They will be randomized to two groups of treatment. SETTING: Psychiatry Department at Bellvitge University Hospital. ANALYSIS: Descriptive analysis of clinical variables; survive analysis and Cox model of regression.
Timeline
- Start
- 2009-07
- Primary completion
- 2014-07
- Completion
- 2014-07
Outcome
Outcome not reported
Stopped (Enrollment): “Difficulties in recruiting”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Aripiprazole | Other / unclassified | 5 mg | — |
| Comparator | Aripiprazole | Other / unclassified | 30 mg | — |
| Comparator | Citalopram | Small molecule | 20 mg | — |
| Comparator | Citalopram | Small molecule | 60 mg | — |
| Comparator | Clomipramine | Small molecule | 75 mg | — |
| Comparator | Clomipramine | Small molecule | 225 mg | — |
| Comparator | Clorazepate | Small molecule | 5 mg | — |
| Comparator | Clorazepate | Small molecule | 50 mg | — |
| Comparator | Diazepam | Small molecule | 2.5 mg | — |
| Comparator | Diazepam | Small molecule | 50 mg | — |
| Comparator | Duloxetine | Small molecule | 60 mg | — |
| Comparator | Duloxetine | Small molecule | 120 mg | — |
| Comparator | Escitalopram | Small molecule | 10 mg | — |
| Comparator | Escitalopram | Small molecule | 20 mg | — |
| Comparator | Fluoxetine | Small molecule | 20 mg | — |
| Comparator | Fluoxetine | Small molecule | 40 mg | — |
| Comparator | Imipramine | Small molecule | 100 mg | — |
| Comparator | Imipramine | Small molecule | 300 mg | — |
| Comparator | Lithium | Unknown | 200 mg | — |
| Comparator | Lithium | Unknown | 1200 mg | — |
| Comparator | Lorazepam | Small molecule | 1 mg | — |
| Comparator | Lorazepam | Small molecule | 10 mg | — |
| Comparator | Mianserin | Small molecule | 10 mg | — |
| Comparator | Mianserin | Small molecule | 60 mg | — |
| Comparator | Mirtazapine | Other / unclassified | 15 mg | — |
| Comparator | Mirtazapine | Other / unclassified | 45 mg | — |
| Comparator | Nortriptyline | Small molecule | 75 mg | — |
| Comparator | Nortriptyline | Small molecule | 200 mg | — |
| Comparator | Olanzapine | Small molecule | 2.5 mg | — |
| Comparator | Olanzapine | Small molecule | 20 mg | — |
| Comparator | Paroxetine | Small molecule | 20 mg | — |
| Comparator | Paroxetine | Small molecule | 40 mg | — |
| Comparator | Quetiapine | Small molecule | 50 mg | — |
| Comparator | Quetiapine | Small molecule | 600 mg | — |
| Comparator | Reboxetin | Unknown | 2 mg | — |
| Comparator | Reboxetin | Unknown | 12 mg | — |
| Comparator | Risperidone | Other / unclassified | 0.5 mg | — |
| Comparator | Risperidone | Other / unclassified | 9 mg | — |
| Comparator | Sertraline | Small molecule | 50 mg | — |
| Comparator | Sertraline | Small molecule | 200 mg | — |
| Comparator | Trazadone | Unknown | 50 mg | — |
| Comparator | Trazadone | Unknown | 200 mg | — |
| Comparator | Venlafaxine | Small molecule | 75 mg | — |
| Comparator | Venlafaxine | Small molecule | 225 mg | — |