Drugs / Imipramine
Imipramine
also known as
Imipramine Hydrochloride · Tofranil · Antideprin · Berkomine · Cristalia · G-22355 · IMI · Imidobenzyle · +17 more
Small molecule targets SLC6A2, SLC6A4 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | PRESAMINE | — | 1959-04-16 | fda.gov ↗ |
Trials 24
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 02 trials | ||||||
| Phase 0 | NCT03960125 | Mar 2021 → Aug 2022 | — | Wright State University | Withdrawn | No outcome recorded |
| Phase 0 | NCT03122444 | Jul 2019 → Mar 2022 | breast cancer | The University of Texas Health Science Center at San Antonio | Completed | No outcome recorded |
| Phase 13 trials · 1 missed | ||||||
| Phase 1 | NCT04520217 | Jun 2022 → Dec 2026 expected | photosensitivity disease | Wright State University | Recruiting | No outcome recorded |
| Phase 1 | NCT03102645 | May → Jun 2017 | female stress incontinence | Jonatan Kornholt | Completed | Missed primary |
| Phase 1 | NCT00946764 | Jul → Sep 2005 | depressive disorder | Sandoz | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT00296725 | Apr 1994 → Jun 2011 | dysthymic disorder, major depressive disorder | New York State Psychiatric Institute | Completed | No outcome recorded |
| Phase 26 trials · 1 met primary | ||||||
| Phase 2 | NCT06778434 | Apr 2025 → Mar 2029 expected | actinic keratosis | VA Office of Research and Development | Recruiting | No outcome recorded |
| Phase 2 | NCT06312813 | Feb 2024 → Dec 2028 expected | rosacea | Wright State University | Recruiting | No outcome recorded |
| Phase 2 | NCT04863950 | May 2022 → Aug 2026 overdue | glioblastoma | The University of Texas Health Science Center at San Antonio | Recruiting | No outcome recorded |
| Phase 2 | NCT01518634 | Jan 2012 → Dec 2014 | somatization disorder | University of Aarhus | Completed | Met primary |
| Phase 2 | NCT00000504 | Sep 1982 → Sep 1985 | cardiac rhythm disease | National Heart, Lung, and Blood Institute (NHLBI) | Completed | No outcome recorded |
| Phase 2 | NCT00000390 | — | depressive disorder | GEIGY Pharmaceuticals | Completed | No outcome recorded |
| Phase 34 trials | ||||||
| Phase 3 | NCT02374567 | Jan 2015 → Jun 2017 | anxiety disorder, dementia, depressive disorder, schizophrenia +1 | Hannover Medical School | Terminated | No outcome recorded |
| Phase 3 | NCT00005575 | Jan 1999 → Dec 2002 | intermediate coronary syndrome | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Completed | No outcome recorded |
| Phase 3 | NCT00000464 | Apr 1987 → Dec 1992 | cardiac arrest, myocardial infarction, ventricular fibrillation | University of Washington | Completed | No outcome recorded |
| Phase 3 | NCT00000518 | Jul 1985 → Dec 1992 | sudden cardiac arrest, ventricular fibrillation, ventricular tachycardia | University of Utah | Completed | No outcome recorded |
| Phase 44 trials | ||||||
| Phase 4 | NCT03548675 | May 2018 → Feb 2022 | major depressive disorder | Radboud University Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT00404755 | Jul 2006 → Aug 2011 | dysthymic disorder, major depressive disorder | New York State Psychiatric Institute | Completed | No outcome recorded |
| Phase 4 | NCT00296777 | Dec 2004 → May 2007 | dysthymic disorder, major depressive disorder | New York State Psychiatric Institute | Completed | No outcome recorded |
| Phase 4 | NCT00227955 | Dec 1987 → Dec 1993 | major depressive disorder | University of Pittsburgh | Completed | No outcome recorded |
| Phase not applicable4 trials | ||||||
| — | NCT06778824 | Apr 2024 → Dec 2026 expected | gastroesophageal reflux disease | Hualien Tzu Chi General Hospital | Recruiting | No outcome recorded |
| — | NCT04478526 | Apr 2020 → May 2021 | generalized anxiety disorder | Dr. Nazanin Alavi | Completed | No outcome recorded |
| — | NCT00206999 | Sep 2004 → Jan 2006 | — | Birte Glenthoj | Completed | No outcome recorded |
| — | NCT00004834 | May 1998 → Jun 2005 | panic disorder | Northwell Health | Completed | No outcome recorded |
| Comparator or background therapy12 trials | ||||||
| Phase 1 | NCT05688904 Comparator | Jan 2023 → Mar 2028 expected | actinic keratosis | Wright State University | Recruiting | No outcome recorded |
| Phase 3 | NCT05677295 Comparator | Apr 2023 → Dec 2024 | female stress incontinence | Far Eastern Memorial Hospital | Unknown | No outcome recorded |
| Phase 3 | NCT04412876 Comparator | May 2020 | female stress incontinence | Far Eastern Memorial Hospital | Withdrawn | No outcome recorded |
| Phase 3 | NCT01753128 Comparator | Dec 2012 → Sep 2013 | gastroesophageal reflux disease | Mahidol University | Completed | No outcome recorded |
| Phase 3 | NCT01179828 Comparator | Jul 2010 → Apr 2015 | — | Insel Gruppe AG, University Hospital Bern | Completed | No outcome recorded |
| Phase 3 | NCT00164775 Comparator | Jun 2005 → Aug 2010 | functional gastric disease | Chinese University of Hong Kong | Completed | No outcome recorded |
| Phase 4 | NCT01047488 Comparator | Feb 2010 → Mar 2013 | polyneuropathy | Odense University Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT01305707 Comparator | Jul 2009 → Jul 2014 | major depressive disorder | Hospital Universitari de Bellvitge | Terminated | No outcome recorded Stop: Enrollment |
| — | NCT06497647 Comparator | Mar → Sep 2024 overdue | nocturnal enuresis | Sohag University | Recruiting | No outcome recorded |
| — | NCT01944657 Comparator | Sep 2013 → Dec 2015 | major depressive disorder | Sheppard Pratt Health System | Withdrawn | No outcome recorded Stop: Enrollment |
| — | NCT01896349 Background | Apr 2013 → Aug 2014 | — | Hospital de Clinicas de Porto Alegre | Unknown | No outcome recorded |
| — | NCT01028014 Comparator | Apr 2010 → Apr 2011 | urethral disorder | University of Alabama at Birmingham | Completed | No outcome recorded |
Evidence & citations 31 cited values
Every value below carries the sentence it was read from. 38 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Imipramine | “If the patient has been deemed unresponsive to both an SSRI and an SNRI/pregabalin, the patient will commence the secondary medication arm. The two classes of medications...” NCT04478526 ↗35“Patients were treated with the TCAs nortriptyline, clomipramine, or imipramine, with clinical follow-up of 7 weeks.” PMID 37155164 ↗ May 2023 “- Imipramine 100-300 mg/d. N06AA02” NCT01305707 ↗ “imipramine (Tofranil and others)” NCT01944657 ↗ |
| Known as | Antideprin | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Berkomine | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Cristalia | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | G-22355 | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | IMI | “Patients are randomized to receive one of five treatments: cognitive-behavioral therapy (CBT) alone, imipramine plus medical management (IMI), CBT plus IMI, pill placebo plus...” NCT00004834 ↗ |
| Known as | Imidobenzyle | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Imipramina | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Imipramine hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Imipramine Hydrochloride | “Imipramine Hydrochloride 50 mg Tablets (Sandoz Inc.)” NCT00946764 ↗1“Drug: Imipramine Hydrochloride” NCT04863950 ↗ |
| Known as | Imipramine hydrochloride rs | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Imipramini hydrochloridum | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Imizine | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Janimine | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Melipramine | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | NSC-114900 | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | NSC-169866 | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | ORG-2463 | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Pramine | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Praminil | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Presamine | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Pryleugan | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Sarimp | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Sermonil | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Known as | Tofranil | “Tofranil Imipramine Hydrochloride 50 mg Tablets (Tyco Healthcare)” NCT00946764 ↗1“imipramine (Tofranil and others)” NCT01944657 ↗ |
| Known as | Trimipramine maleate impurity, imipramine- | ChEMBL registry synonym — accepted as the source's own label CHEMBL11 ↗ |
| Action | Inhibit | “combined serotonin- and noradrenaline re-uptake inhibitor” NCT00206999 ↗ |
| Modality | Small molecule | “imipramine, a tricyclic antidepressant (TCA)” PMID 30361080 ↗ Oct 2018 |
| Route | Oral | “Oral IMI or placebo is taken daily.” NCT00004834 ↗ |
| Target | SLC6A2 | “Norepinephrine transporter inhibitor” CHEMBL11 ↗ |
| Target | SLC6A4 | “Serotonin transporter inhibitor” CHEMBL11 ↗ |