drugset / Trial / NCT00206999
The Effect of Imipramine on Early Information Processing
Completed
20 enrolled
Birte Glenthoj
Glostrup University Hospital, Copenhagen · collabLundbeck Foundation · collabThe Danish Medical Research Council · collabUniversity of Copenhagen · collab
RandomizedCrossoverQuadruple-blindDiagnostic
Summary
We wanted to compare the relation of two different psychophysiological paradigms (PrePulse Inhibition of the startle response = PPI and P50 suppression) to each other. Additionally, we wanted to test the effect of the combined serotonin- and noradrenaline re-uptake inhibitor, imipramine, on these measures. The primary hypothesis was that PPI and P50 gating would not correlate with each other at baseline. The secondary hypothesis was that increased noradrenergic and serotonergic activity would disrupt PPI as well as P50 gating.
Timeline
- Start
- 2004-09
- Primary completion
- 2006-01
- Completion
- 2006-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Imipramine | Small molecule | 50 mg | — |
Indications
No indication recorded.